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N-acetylcysteine supplementation improves endocrine-metabolism profiles and ovulation induction efficacy in polycystic ovary syndrome.
Fang YQ, Ding H, Li T, Zhao XJ, Luo D, Liu Y, Li Y. Fang YQ, et al. J Ovarian Res. 2024 Oct 16;17(1):205. doi: 10.1186/s13048-024-01528-8. J Ovarian Res. 2024. PMID: 39415242 Free PMC article. Clinical Trial.
Hyperinsulinemia exacerbates oxidative stress, contributing to PCOS pathogenesis. N-acetylcysteine (NAC) is an antioxidant and insulin sensitizer that shows promise as a therapeutic for PCOS. Our current study aimed to investigate the effects of NAC su …
Hyperinsulinemia exacerbates oxidative stress, contributing to PCOS pathogenesis. N-acetylcysteine (NAC) is an antioxid …
The effects of N-acetylcysteine on ovulation and sex hormones profile in women with polycystic ovary syndrome: a systematic review and meta-analysis.
Shahveghar Asl Z, Parastouei K, Eskandari E. Shahveghar Asl Z, et al. Br J Nutr. 2023 Jul 28;130(2):202-210. doi: 10.1017/S0007114522003270. Epub 2023 Jan 4. Br J Nutr. 2023. PMID: 36597797
Clinical trials on the effects of N-acetylcysteine (NAC) supplementation on ovulation and sex hormones profile in women with PCOS have been controversial. ...Overall, NAC supplementation might be effective in the improvement of reproductive system func …
Clinical trials on the effects of N-acetylcysteine (NAC) supplementation on ovulation and sex hormones profile in women …
Oxidative Stress in Polycystic Ovarian Syndrome and the Effect of Antioxidant N-Acetylcysteine on Ovulation and Pregnancy Rate.
Sandhu JK, Waqar A, Jain A, Joseph C, Srivastava K, Ochuba O, Alkayyali T, Ruo SW, Poudel S. Sandhu JK, et al. Cureus. 2021 Sep 11;13(9):e17887. doi: 10.7759/cureus.17887. eCollection 2021 Sep. Cureus. 2021. PMID: 34660086 Free PMC article. Review.
Polycystic ovarian syndrome (PCOS) is an endocrinological condition that leads to infertility in many females. N-acetylcysteine (NAC), a novel antioxidant, is being used as an adjuvant to treat infertility in females suffering from PCOS. ...A literatur …
Polycystic ovarian syndrome (PCOS) is an endocrinological condition that leads to infertility in many females. N-acetylcyst …
N-Acetylcysteine as an Adjuvant to Letrozole for Induction of Ovulation in Infertile Patients with Polycystic Ovary Syndrome.
Mostajeran F, Tehrani HG, Rahbary B. Mostajeran F, et al. Adv Biomed Res. 2018 Jun 25;7:100. doi: 10.4103/abr.abr_157_17. eCollection 2018. Adv Biomed Res. 2018. PMID: 30050888 Free PMC article.
BACKGROUND: This study was aimed to evaluate the influence of oral N-acetylcysteine (NAC) application as an adjuvant to letrozole on induced ovulation outcomes in patients with polycystic ovary syndrome (PCOS). ...CONCLUSION: NAC is demonstrated to be …
BACKGROUND: This study was aimed to evaluate the influence of oral N-acetylcysteine (NAC) application as an adjuvant to letroz …
Effects of N-acetylcysteine and metformin treatment on the stereopathological characteristics of uterus and ovary.
Rafiee B, Karbalay-Doust S, Tabei SMB, Azarpira N, Alaee S, Lohrasbi P, Bahmanpour S. Rafiee B, et al. Eur J Transl Myol. 2022 May 9;32(2):10409. doi: 10.4081/ejtm.2022.10409. Eur J Transl Myol. 2022. Retraction in: Eur J Transl Myol. 2025 Dec 19;35(4). doi: 10.4081/ejtm.2025.14616. PMID: 35535444 Free PMC article. Retracted.
In this study, the stereo-pathological effect of metformin and N-acetyl cysteine is evaluated on the uterus and ovary of polycystic ovary syndrome (PCOS) mice. 96 mature females (8-weekold, weight of 20-30 gr) BALB/c mice were classified into 6 groups including the control …
In this study, the stereo-pathological effect of metformin and N-acetyl cysteine is evaluated on the uterus and ovary of polycystic ovary sy …
N-acetylcysteine for polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled clinical trials.
Thakker D, Raval A, Patel I, Walia R. Thakker D, et al. Obstet Gynecol Int. 2015;2015:817849. doi: 10.1155/2015/817849. Epub 2015 Jan 8. Obstet Gynecol Int. 2015. PMID: 25653680 Free PMC article. Review.
Objective. To review the benefits and harms of N-acetylcysteine (NAC) in women with polycystic ovary syndrome (PCOS). Method. Literature search was conducted using the bibliographic databases, MEDLINE (Ovid), CINAHL, EMBASE, Scopus, PsyInfo, and PROQUEST (fro …
Objective. To review the benefits and harms of N-acetylcysteine (NAC) in women with polycystic ovary syndrome (PCOS). M …
N-Acetylcysteine as an adjuvant to clomiphene citrate for successful induction of ovulation in infertile patients with polycystic ovary syndrome.
Salehpour S, Sene AA, Saharkhiz N, Sohrabi MR, Moghimian F. Salehpour S, et al. J Obstet Gynaecol Res. 2012 Sep;38(9):1182-6. doi: 10.1111/j.1447-0756.2012.01844.x. Epub 2012 Apr 30. J Obstet Gynaecol Res. 2012. PMID: 22540635 Clinical Trial.
AIM: The aim of this study was to evaluate the effect of oral N-acetylcysteine (NAC) administration as an adjuvant to clomiphene citrate (CC) on induction of ovulation outcomes in patients with polycystic ovary syndrome (PCOS). ...CONCLUSION: NAC as a …
AIM: The aim of this study was to evaluate the effect of oral N-acetylcysteine (NAC) administration as an adjuvant to clomiphe …
Randomized controlled trial of N-acetylcysteine versus l-carnitine among women with clomiphene-citrate-resistant polycystic ovary syndrome.
El Sharkwy IA, Abd El Aziz WM. El Sharkwy IA, et al. Int J Gynaecol Obstet. 2019 Oct;147(1):59-64. doi: 10.1002/ijgo.12902. Epub 2019 Jul 17. Int J Gynaecol Obstet. 2019. Retraction in: Int J Gynaecol Obstet. 2023 Sep;162(3):1130. doi: 10.1002/ijgo.14995. PMID: 31273783 Retracted. Clinical Trial.
OBJECTIVE: To compare clinical and metabolic profiles between N-acetylcysteine and l-carnitine among women with clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS). ...CONCLUSIONS: Both N-acetylcysteine and l-carnitine were equall …
OBJECTIVE: To compare clinical and metabolic profiles between N-acetylcysteine and l-carnitine among women with clomiphene cit …
The adjuvant effect of metformin and N-acetylcysteine to clomiphene citrate in induction of ovulation in patients with Polycystic Ovary Syndrome.
Maged AM, Elsawah H, Abdelhafez A, Bakry A, Mostafa WA. Maged AM, et al. Gynecol Endocrinol. 2015;31(8):635-8. doi: 10.3109/09513590.2015.1037269. Epub 2015 Aug 4. Gynecol Endocrinol. 2015. Retraction in: Gynecol Endocrinol. 2025 Dec 31;41(1):2600208. doi: 10.1080/09513590.2025.2600208. PMID: 26291797 Retracted. Clinical Trial.
OBJECTIVES: To assess the adjuvant effect of metformin and N-acetylcysteine (NAC) to clomiphene citrate (CC) in induction of ovulation in Polycystic Ovary Syndrome (PCOS) patients. ...CONCLUSIONS: NAC as an adjuvant to CC for induction of ovulation …
OBJECTIVES: To assess the adjuvant effect of metformin and N-acetylcysteine (NAC) to clomiphene citrate (CC) in induction of …
N-Acetylcysteine Compared to Metformin, Improves The Expression Profile of Growth Differentiation Factor-9 and Receptor Tyrosine Kinase c-Kit in The Oocytes of Patients with Polycystic Ovarian Syndrome.
Cheraghi E, Soleimani Mehranjani M, Shariatzadeh SMA, Nasr Esfahani MH, Alani B. Cheraghi E, et al. Int J Fertil Steril. 2018 Jan;11(4):270-278. doi: 10.22074/ijfs.2018.5142. Epub 2017 Oct 12. Int J Fertil Steril. 2018. PMID: 29043702 Free PMC article.
BACKGROUND: Paracrine disruption of growth factors in women with polycystic ovarian syndrome (PCOS) results in production of low quality oocyte, especially following ovulation induction. The aim of this study was to investigate the effects of metformin (MET), N …
BACKGROUND: Paracrine disruption of growth factors in women with polycystic ovarian syndrome (PCOS) results in production of low qual …
22 results