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1976 1
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636 results

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Page 1
Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease.
Chidiac AS, Buckley NA, Noghrehchi F, Cairns R. Chidiac AS, et al. Expert Opin Drug Metab Toxicol. 2023 Jan-Jun;19(5):297-317. doi: 10.1080/17425255.2023.2223959. Expert Opin Drug Metab Toxicol. 2023. PMID: 37436926 Free article. Review.
INTRODUCTION: Paracetamol is one of the most used medicines worldwide and is the most common important poisoning in high-income countries. In overdose, paracetamol causes dose-dependent hepatotoxicity. Acetylcysteine is an effective antidote, however d …
INTRODUCTION: Paracetamol is one of the most used medicines worldwide and is the most common important poisoning in high-income count …
Acetaminophen Hepatotoxicity: Paradigm for Understanding Mechanisms of Drug-Induced Liver Injury.
Jaeschke H, Ramachandran A. Jaeschke H, et al. Annu Rev Pathol. 2024 Jan 24;19:453-478. doi: 10.1146/annurev-pathmechdis-051122-094016. Annu Rev Pathol. 2024. PMID: 38265880 Free PMC article. Review.
Acetaminophen (APAP) overdose is the clinically most relevant drug hepatotoxicity in western countries, and, because of translational relevance of animal models, APAP is mechanistically the most studied drug. ...Understanding these mechanisms of cell death led to di …
Acetaminophen (APAP) overdose is the clinically most relevant drug hepatotoxicity in western countries, and, because of transl …
Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose.
Akakpo JY, Ramachandran A, Curry SC, Rumack BH, Jaeschke H. Akakpo JY, et al. Arch Toxicol. 2022 Feb;96(2):453-465. doi: 10.1007/s00204-021-03211-z. Epub 2022 Jan 3. Arch Toxicol. 2022. PMID: 34978586 Free PMC article. Review.
Acetaminophen (APAP) overdose can cause hepatotoxicity and even liver failure. N-acetylcysteine (NAC) is still the only FDA-approved antidote against APAP overdose 40 years after its introduction. ...
Acetaminophen (APAP) overdose can cause hepatotoxicity and even liver failure. N-acetylcysteine (NAC) is still t …
What is the most appropriate dose of N-acetylcysteine after massive acetaminophen overdose?
Hendrickson RG. Hendrickson RG. Clin Toxicol (Phila). 2019 Aug;57(8):686-691. doi: 10.1080/15563650.2019.1579914. Epub 2019 Feb 19. Clin Toxicol (Phila). 2019. PMID: 30777470 Review.
While the traditional intravenous N-acetylcysteine (NAC) dosing regimen works well for the vast majority of acetaminophen overdoses, there may be cases of massive overdose where additional NAC may be necessary. Recent evidence suggests that patients with a …
While the traditional intravenous N-acetylcysteine (NAC) dosing regimen works well for the vast majority of acetaminophen …
Clinically relevant therapeutic approaches against acetaminophen hepatotoxicity and acute liver failure.
Ramachandran A, Akakpo JY, Curry SC, Rumack BH, Jaeschke H. Ramachandran A, et al. Biochem Pharmacol. 2024 Oct;228:116056. doi: 10.1016/j.bcp.2024.116056. Epub 2024 Feb 10. Biochem Pharmacol. 2024. PMID: 38346541 Free PMC article. Review.
Liver injury and acute liver failure caused by an acetaminophen (APAP) overdose is a significant clinical problem in western countries. With the introduction of the mouse model of APAP hepatotoxicity in the 1970 s, fundamental mechanisms of cell death were discovere …
Liver injury and acute liver failure caused by an acetaminophen (APAP) overdose is a significant clinical problem in western countrie …
Acetaminophen Poisoning.
Chiew AL, Buckley NA. Chiew AL, et al. Crit Care Clin. 2021 Jul;37(3):543-561. doi: 10.1016/j.ccc.2021.03.005. Crit Care Clin. 2021. PMID: 34053705 Review.
Acetaminophen is a common medication taken in deliberate self-poisoning and unintentional overdose. It is the commonest cause of severe acute liver injury in Western countries. The optimal management of most acetaminophen poisonings is usually straightforward. Patie …
Acetaminophen is a common medication taken in deliberate self-poisoning and unintentional overdose. It is the commonest cause of seve …
Paracetamol (acetaminophen) poisoning: The early years.
Prescott LF. Prescott LF. Br J Clin Pharmacol. 2024 Jan;90(1):127-134. doi: 10.1111/bcp.15903. Epub 2023 Sep 21. Br J Clin Pharmacol. 2024. PMID: 37683599 Free article. Review.
This had unpleasant side effects and administration was difficult. N-acetylcysteine soon became the treatment of choice for paracetamol overdose and given early it was very effective when administered either IV or orally. N-acetylcysteine could …
This had unpleasant side effects and administration was difficult. N-acetylcysteine soon became the treatment of choice for …
Acetaminophen-related hepatotoxicity.
Bunchorntavakul C, Reddy KR. Bunchorntavakul C, et al. Clin Liver Dis. 2013 Nov;17(4):587-607, viii. doi: 10.1016/j.cld.2013.07.005. Epub 2013 Sep 4. Clin Liver Dis. 2013. PMID: 24099020 Review.
Acetaminophen (APAP) is the leading worldwide cause of drug overdose and acute liver failure (ALF). ...N-acetylcysteine is a very effective antidote when giving within 8 hours, and is also recommended after a presentation of hepatotoxicity and ALF. ...
Acetaminophen (APAP) is the leading worldwide cause of drug overdose and acute liver failure (ALF). ...N-acetylcysteine …
Acetaminophen hepatotoxicity.
Larson AM. Larson AM. Clin Liver Dis. 2007 Aug;11(3):525-48, vi. doi: 10.1016/j.cld.2007.06.006. Clin Liver Dis. 2007. PMID: 17723918 Review.
Acetaminophen is a commonly used antipyretic and analgesic agent. It is safe when taken at therapeutic doses; however, overdose can lead to serious and even fatal hepatotoxicity. ...Prompt recognition of overdose, aggressive management, and administration of N …
Acetaminophen is a commonly used antipyretic and analgesic agent. It is safe when taken at therapeutic doses; however, overdose can l …
Acetaminophen Hepatotoxicity.
Ramachandran A, Jaeschke H. Ramachandran A, et al. Semin Liver Dis. 2019 May;39(2):221-234. doi: 10.1055/s-0039-1679919. Epub 2019 Mar 8. Semin Liver Dis. 2019. PMID: 30849782 Free PMC article.
Acetaminophen (APAP) is one of the most popular and safe pain medications worldwide. However, due to its wide availability, it is frequently implicated in intentional or unintentional overdoses where it can cause severe liver injury and even acute liver failure (ALF). ...T …
Acetaminophen (APAP) is one of the most popular and safe pain medications worldwide. However, due to its wide availability, it is fre …
636 results