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546 results

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Page 1
Intravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure.
Lee WM, Hynan LS, Rossaro L, Fontana RJ, Stravitz RT, Larson AM, Davern TJ 2nd, Murray NG, McCashland T, Reisch JS, Robuck PR; Acute Liver Failure Study Group. Lee WM, et al. Gastroenterology. 2009 Sep;137(3):856-64, 864.e1. doi: 10.1053/j.gastro.2009.06.006. Epub 2009 Jun 12. Gastroenterology. 2009. PMID: 19524577 Free PMC article. Clinical Trial.
BACKGROUND & AIMS: N-acetylcysteine (NAC), an antidote for acetaminophen poisoning, might benefit patients with non-acetaminophen-related acute liver failure. ...CONCLUSIONS: Intravenous NAC improves transplant-free survival in patients with …
BACKGROUND & AIMS: N-acetylcysteine (NAC), an antidote for acetaminophen poisoning, might benefit patients with non-acetam …
N-acetylcysteine for non-acetaminophen induced acute liver failure: A review.
Jiang SX, Hussaini T, Yoshida EM. Jiang SX, et al. Saudi J Gastroenterol. 2022 Mar-Apr;28(2):85-91. doi: 10.4103/sjg.sjg_406_21. Saudi J Gastroenterol. 2022. PMID: 35142656 Free PMC article. Review.
The use of N-acetylcysteine (NAC) for non-acetaminophen-induced acute liver failure (NAI-ALF) has been increasing despite controversy in its efficacy. ...Murine models have reported antioxidant and anti-inflammatory properties, as well as improv …
The use of N-acetylcysteine (NAC) for non-acetaminophen-induced acute liver failure (NAI-ALF) has been in …
N-acetylcysteine in non-acetaminophen-induced acute liver failure: a systematic review and meta-analysis of prospective studies.
Amjad W, Thuluvath P, Mansoor M, Dutta A, Ali F, Qureshi W. Amjad W, et al. Prz Gastroenterol. 2022;17(1):9-16. doi: 10.5114/pg.2021.107797. Epub 2021 Jul 14. Prz Gastroenterol. 2022. PMID: 35371352 Free PMC article. Review.
INTRODUCTION: There are discordant reports on N-acetylcysteine (NAC) efficacy in non-acetaminophen acute liver failure (ALF). AIM: To determine whether NAC is beneficial in non-acetaminophen ALF. ...CONCLUSIONS: The treatment of patients with …
INTRODUCTION: There are discordant reports on N-acetylcysteine (NAC) efficacy in non-acetaminophen acute liver …
Acute liver failure: Management update and prognosis.
Martínez-Martínez LM, Rosales-Sotomayor G, Jasso-Baltazar EA, Torres-Díaz JA, Aguirre-Villarreal D, Hurtado-Díaz de León I, Páez-Zayas VM, Sánchez-Cedillo A, Martínez-Vázquez SE, Tadeo-Espinoza HN, Guerrero-Cabrera JP, García-Alanis M, García-Juárez I. Martínez-Martínez LM, et al. Rev Gastroenterol Mex (Engl Ed). 2024 Jul-Sep;89(3):404-417. doi: 10.1016/j.rgmxen.2024.05.002. Epub 2024 Jul 20. Rev Gastroenterol Mex (Engl Ed). 2024. PMID: 39033039 Free article. Review.
Acute liver failure is a rare but serious syndrome, with an incidence of approximately 2,000 to 3,000 cases per year in North America. ...Survival has improved with supportive measures, intensive therapy, complication prevention, and the use of medications, s …
Acute liver failure is a rare but serious syndrome, with an incidence of approximately 2,000 to 3,000 cases per year in …
Acute liver failure.
Vasques F, Cavazza A, Bernal W. Vasques F, et al. Curr Opin Crit Care. 2022 Apr 1;28(2):198-207. doi: 10.1097/MCC.0000000000000923. Curr Opin Crit Care. 2022. PMID: 35142727 Review.
PURPOSE OF REVIEW: Present an outline of acute liver failure, from its definition to its management in critical care, updated with findings of selected newer research. RECENT FINDINGS: Survival of patients with acute liver failure has pro …
PURPOSE OF REVIEW: Present an outline of acute liver failure, from its definition to its management in critical care, u …
N-acetylcysteine for non-paracetamol (acetaminophen)-related acute liver failure.
Siu JT, Nguyen T, Turgeon RD. Siu JT, et al. Cochrane Database Syst Rev. 2020 Dec 9;12(12):CD012123. doi: 10.1002/14651858.CD012123.pub2. Cochrane Database Syst Rev. 2020. PMID: 33294991 Free PMC article.
N-acetylcysteine has been successful in treating paracetamol-induced acute liver failure and reduces the risk of needing to undergo liver transplantation. ...OBJECTIVES: To assess the benefits and harms of N-acetylcysteine c …
N-acetylcysteine has been successful in treating paracetamol-induced acute liver failure and reduces the …
Future directions in acute liver failure.
Stravitz RT, Fontana RJ, Karvellas C, Durkalski V, McGuire B, Rule JA, Tujios S, Lee WM; Acute Liver Failure Study Group. Stravitz RT, et al. Hepatology. 2023 Oct 1;78(4):1266-1289. doi: 10.1097/HEP.0000000000000458. Epub 2023 May 16. Hepatology. 2023. PMID: 37183883 Free PMC article. Review.
Acute liver failure (ALF) describes a clinical syndrome of rapid hepatocyte injury leading to liver failure manifested by coagulopathy and encephalopathy in the absence of pre-existing cirrhosis. ...As a rare, orphan disease, it seemed an obviou …
Acute liver failure (ALF) describes a clinical syndrome of rapid hepatocyte injury leading to liver failure …
Role of N-acetylcysteine in non-acetaminophen-related acute liver failure: an updated meta-analysis and systematic review.
Walayat S, Shoaib H, Asghar M, Kim M, Dhillon S. Walayat S, et al. Ann Gastroenterol. 2021;34(2):235-240. doi: 10.20524/aog.2021.0571. Epub 2021 Jan 4. Ann Gastroenterol. 2021. PMID: 33654365 Free PMC article.
BACKGROUND: The American Association for the Study of Liver Diseases recommends that N-acetylcysteine (NAC) may be beneficial in non-acetaminophen-related drug-induced liver injury. ...CONCLUSION: In patients with non-acetaminophen-related acute …
BACKGROUND: The American Association for the Study of Liver Diseases recommends that N-acetylcysteine (NAC) may be bene …
Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease.
Chidiac AS, Buckley NA, Noghrehchi F, Cairns R. Chidiac AS, et al. Expert Opin Drug Metab Toxicol. 2023 Jan-Jun;19(5):297-317. doi: 10.1080/17425255.2023.2223959. Expert Opin Drug Metab Toxicol. 2023. PMID: 37436926 Free article. Review.
In overdose, paracetamol causes dose-dependent hepatotoxicity. Acetylcysteine is an effective antidote, however despite its use hepatotoxicity and many deaths still occur. ...Where data were available, we estimate that paracetamol is involved in 6% of poisonings, 56% of se …
In overdose, paracetamol causes dose-dependent hepatotoxicity. Acetylcysteine is an effective antidote, however despite its use hepat …
Acute Liver Failure.
Bunchorntavakul C, Reddy KR. Bunchorntavakul C, et al. Clin Liver Dis. 2017 Nov;21(4):769-792. doi: 10.1016/j.cld.2017.06.002. Epub 2017 Jul 29. Clin Liver Dis. 2017. PMID: 28987262 Review.
Acute liver failure (ALF) is a life-threatening condition of heterogeneous etiology. Outcomes are better with early recognition and prompt initiation of etiology-specific therapy, intensive care protocols, and liver transplantation (LT). ...Extracorpor …
Acute liver failure (ALF) is a life-threatening condition of heterogeneous etiology. Outcomes are better with early rec …
546 results