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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 2
1966 2
1967 2
1968 3
1969 1
1970 1
1971 5
1973 3
1974 5
1975 2
1977 3
1978 1
1981 1
1982 2
1983 3
1984 3
1985 5
1986 2
1987 3
1988 1
1992 3
1994 1
1995 1
1997 1
1998 3
1999 1
2000 3
2001 1
2002 6
2003 5
2004 2
2005 4
2006 5
2007 3
2008 5
2009 4
2010 8
2011 2
2012 6
2013 13
2014 4
2015 2
2016 2
2017 4
2018 5
2019 8
2020 12
2021 12
2022 3
2023 5
2024 7
2025 11
2026 5

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201 results

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Page 1
N-acetylcysteine decreases airway inflammation and responsiveness in asthma by modulating claudin 18 expression.
Lee PH, Hong J, Jang AS. Lee PH, et al. Korean J Intern Med. 2020 Sep;35(5):1229-1237. doi: 10.3904/kjim.2019.105. Epub 2020 Feb 28. Korean J Intern Med. 2020. PMID: 32098455 Free PMC article.
BACKGROUND/AIMS: N-acetylcysteine (NAC) affects signaling pathways involved in apoptosis, angiogenesis, cell growth and arrest, redox-regulated gene expression, and the inflammatory response. However, it is not known how the signal mechanism for tight junctional pro …
BACKGROUND/AIMS: N-acetylcysteine (NAC) affects signaling pathways involved in apoptosis, angiogenesis, cell growth and arrest …
Protective effects of N-acetylcysteine on a chemical-induced murine model of asthma.
Song J, Yao L, Shi J, Li J, Xu C. Song J, et al. J Asthma. 2021 Sep;58(9):1208-1215. doi: 10.1080/02770903.2020.1781166. Epub 2020 Jun 26. J Asthma. 2021. PMID: 32546031
INTRODUCTION: Oxidative stress is involved in the pathophysiology of inflammatory airway diseases, including asthma. In this study, we elucidated the possible protective effects of the antioxidant N-acetylcysteine (NAC) on a toluene diisocyanate (TDI)-induced …
INTRODUCTION: Oxidative stress is involved in the pathophysiology of inflammatory airway diseases, including asthma. In this study, w …
Perioperative N-acetylcysteine: evidence and indications.
Wilson PR, Bridges KH, Scofield M, Wilson SH. Wilson PR, et al. Pain Manag. 2024;14(7):385-396. doi: 10.1080/17581869.2024.2388504. Epub 2024 Aug 21. Pain Manag. 2024. PMID: 39166871 Free PMC article. Review.
Nonopioid analgesics serve to improve analgesia and limit side effects and risks of perioperative opioids. N-acetylcysteine (NAC), the primary treatment of acetaminophen toxicity, may have perioperative indications, including analgesia. ...Nonopioid mediations are i …
Nonopioid analgesics serve to improve analgesia and limit side effects and risks of perioperative opioids. N-acetylcysteine (N …
N-Acetylcysteine and Its Therapeutic Potential in an Animal Model of Allergic Asthma.
Smieško L, Mažerik J, Gondáš E, Dohál M, Jošková M, Šutovská M, Fraňová S. Smieško L, et al. J Aerosol Med Pulm Drug Deliv. 2025 Jun;38(3):118-126. doi: 10.1089/jamp.2024.0049. Epub 2025 Mar 17. J Aerosol Med Pulm Drug Deliv. 2025. PMID: 40094443 Free article.
Background: N-acetylcysteine (NAC) is a classical mucolytic agent that, in addition to its mucolytic activity, also exhibits antioxidant activity. This could be beneficial in treating chronic inflammatory airway diseases, including asthma. Background: We eval …
Background: N-acetylcysteine (NAC) is a classical mucolytic agent that, in addition to its mucolytic activity, also exhibits a …
Effects of N-acetylcysteine on asthma exacerbation.
Aliyali M, Poorhasan Amiri A, Sharifpoor A, Zalli F. Aliyali M, et al. Iran J Allergy Asthma Immunol. 2010 Jun;9(2):103-9. Iran J Allergy Asthma Immunol. 2010. PMID: 20683104 Free article. Clinical Trial.
Airway mucus hypersecretion and increased oxidative stress are clinical and pathophysiological features of asthma exacerbation. We studied effects of N-acetylcysteine (NAC) as a mucolytic and antioxidant agent in asthma exacerbation. In this randomized …
Airway mucus hypersecretion and increased oxidative stress are clinical and pathophysiological features of asthma exacerbation. We st …
Effectiveness of oral N -acetylcysteine in a rat experimental model of asthma.
Blesa S, Cortijo J, Martinez-Losa M, Mata M, Seda E, Santangelo F, Morcillo EJ. Blesa S, et al. Pharmacol Res. 2002 Feb;45(2):135-40. doi: 10.1006/phrs.2001.0917. Pharmacol Res. 2002. PMID: 11846626
Oxidative stress appears to be relevant to asthma pathogenesis. Therefore, the effectiveness of the antioxidant N -acetylcysteine was examined on antigen-induced pulmonary responses in sensitized Brown-Norway rats. ...Taurine levels in bronchoalveolar lavage …
Oxidative stress appears to be relevant to asthma pathogenesis. Therefore, the effectiveness of the antioxidant N -acetylcy …
Molecular mechanism of interleukin-17A regulating airway epithelial cell ferroptosis based on allergic asthma airway inflammation.
Song J, Zhang H, Tong Y, Wang Y, Xiang Q, Dai H, Weng C, Wang L, Fan J, Shuai Y, Lai C, Fang X, Chen M, Bao J, Zhang W. Song J, et al. Redox Biol. 2023 Dec;68:102970. doi: 10.1016/j.redox.2023.102970. Epub 2023 Nov 22. Redox Biol. 2023. PMID: 38035662 Free PMC article.
Interleukin-17A (IL-17A) levels are elevated in patients with asthma. Ferroptosis has been identified as the non-apoptotic cell death type associated with asthma. Data regarding the relation of ferroptosis with asthma and the effect of IL-17A on modulating fe …
Interleukin-17A (IL-17A) levels are elevated in patients with asthma. Ferroptosis has been identified as the non-apoptotic cell death …
Mucolytic agents versus placebo for chronic bronchitis or chronic obstructive pulmonary disease.
Poole P, Sathananthan K, Fortescue R. Poole P, et al. Cochrane Database Syst Rev. 2019 May 20;5(5):CD001287. doi: 10.1002/14651858.CD001287.pub6. Cochrane Database Syst Rev. 2019. PMID: 31107966 Free PMC article.
SELECTION CRITERIA: We included randomised studies that compared oral mucolytic therapy versus placebo for at least two months in adults with chronic bronchitis or COPD. We excluded studies of people with asthma and cystic fibrosis. DATA COLLECTION AND ANALYSIS: This revie …
SELECTION CRITERIA: We included randomised studies that compared oral mucolytic therapy versus placebo for at least two months in adults wit …
N-acetylcysteine attenuates benzo[a]pyrene-exacerbated asthma lung injury by inhibiting mucous hypersecretion and apoptosis via the ROS/CREB/ERK pathway.
Yu T, Wang B. Yu T, et al. J Asthma. 2026 May;63(5):551-560. doi: 10.1080/02770903.2025.2612521. Epub 2026 Jan 12. J Asthma. 2026. PMID: 41503729
OBJECTIVE: To investigate the protective effect of N-acetylcysteine (NAC) against benzo[a]pyrene (BaP)-aggravated lung injury in asthma and to elucidate whether it is mediated through the ROS/CREB/ERK signaling pathway. ...This study provides experimental evi …
OBJECTIVE: To investigate the protective effect of N-acetylcysteine (NAC) against benzo[a]pyrene (BaP)-aggravated lung injury …
Advances in the Use of N-Acetylcysteine in Chronic Respiratory Diseases.
Mokra D, Mokry J, Barosova R, Hanusrichterova J. Mokra D, et al. Antioxidants (Basel). 2023 Sep 2;12(9):1713. doi: 10.3390/antiox12091713. Antioxidants (Basel). 2023. PMID: 37760016 Free PMC article. Review.
N-acetylcysteine (NAC) is widely used because of its mucolytic effects, taking part in the therapeutic protocols of cystic fibrosis. ...Thanks to its wide antioxidative and anti-inflammatory effects, NAC may also be of benefit in other chronic inflammatory and fibro …
N-acetylcysteine (NAC) is widely used because of its mucolytic effects, taking part in the therapeutic protocols of cystic fib …
201 results