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Effectiveness of N-acetylcysteine in autism spectrum disorders: A meta-analysis of randomized controlled trials.
Lee TM, Lee KM, Lee CY, Lee HC, Tam KW, Loh EW. Lee TM, et al. Aust N Z J Psychiatry. 2021 Feb;55(2):196-206. doi: 10.1177/0004867420952540. Epub 2020 Sep 8. Aust N Z J Psychiatry. 2021. PMID: 32900213
Here, we analyzed the treatment effects of N-acetylcysteine on autism spectrum disorder in randomized controlled trials. STUDY DESIGN: Updated systematic review and meta-analysis. ...No differences were observed in the pooled results of two trials usin …
Here, we analyzed the treatment effects of N-acetylcysteine on autism spectrum disorder in randomized controlled …
N-acetylcysteine improves autism-like behavior by recovering autophagic deficiency and decreasing Notch-1/Hes-1 pathway activity.
Zhang YH, Wang T, Li YF, Deng YN, He XL, Wang LJ. Zhang YH, et al. Exp Biol Med (Maywood). 2023 Jun;248(11):966-978. doi: 10.1177/15353702231179924. Epub 2023 Jun 28. Exp Biol Med (Maywood). 2023. PMID: 37377100 Free PMC article.
N-acetylcysteine (NAC) has been reported to improve social interaction behavior, irritability, self-injury, and anxiety-like behavior in autism. However, the molecular mechanism underlying the therapeutic roles of NAC in autism remains unknown. …
N-acetylcysteine (NAC) has been reported to improve social interaction behavior, irritability, self-injury, and anxiety …
Possible effects of N-acetylcysteine in autism spectrum disorders: major clinical aspects, eating behaviors, and sleeping habits.
Nalbant K, Erden S. Nalbant K, et al. Turk J Pediatr. 2023;65(5):832-844. doi: 10.24953/turkjped.2022.573. Turk J Pediatr. 2023. PMID: 37853974 Free article.
BACKGROUND: N-acetylcysteine (NAC) is a promising agent for reducing irritability and hyperactivity and enhancing social responsiveness in children with autism spectrum disorders (ASD). ...RESULTS: Our findings suggested that oral NAC alleviated the in …
BACKGROUND: N-acetylcysteine (NAC) is a promising agent for reducing irritability and hyperactivity and enhancing socia …
Emerging drugs for the treatment of irritability associated with autism spectrum disorder.
Shamabadi A, Karimi H, Arabzadeh Bahri R, Motavaselian M, Akhondzadeh S. Shamabadi A, et al. Expert Opin Emerg Drugs. 2024 Mar;29(1):45-56. doi: 10.1080/14728214.2024.2313650. Epub 2024 Feb 4. Expert Opin Emerg Drugs. 2024. PMID: 38296815 Review.
INTRODUCTION: Autism spectrum disorder (ASD) is an early-onset disorder with a prevalence of 1% among children and reported disability-adjusted life years of 4.31 million. ...EXPERT OPINION: Succeeding risperidone and aripiprazole, monotherapy with memantine …
INTRODUCTION: Autism spectrum disorder (ASD) is an early-onset disorder with a prevalence of 1% among children and repo …
The Use of N-acetylcysteine Supplementation to Decrease Irritability in Four Youths With Autism Spectrum Disorders.
Pesko MJ, Burbige EM, Sannar EM, Beresford C, Rogers C, Ariefdjohan M, Stutzman D. Pesko MJ, et al. J Pediatr Pharmacol Ther. 2020;25(2):149-154. doi: 10.5863/1551-6776-25.2.149. J Pediatr Pharmacol Ther. 2020. PMID: 32071590 Free PMC article.
Children and adolescents with autism spectrum disorder (ASD) often experience high levels of irritability, which adversely affects their functioning and behaviors. N-acetylcysteine (NAC), an antioxidant precursor to glutathione, has recently bee …
Children and adolescents with autism spectrum disorder (ASD) often experience high levels of irritability, which advers …
The Emerging Role of N-Acetylcysteine in Psychiatry: A Narrative Review of Available Data.
Marazziti D, Caruso V, Cappellato G, Chiarantini I, Gurrieri R, Perrone P, Violi M, Crivelli NSB, Weiss F, Perugi G. Marazziti D, et al. Curr Med Chem. 2025 Sep 23. doi: 10.2174/0109298673365458250901115725. Online ahead of print. Curr Med Chem. 2025. PMID: 40993955
N-acetylcysteine (NAC), a cysteine derivative with a reactive thiol group, possesses antioxidant and anti-inflammatory properties. ...This narrative review examines the efficacy of NAC in treating psychiatric conditions, including mood disorders, schizophreni …
N-acetylcysteine (NAC), a cysteine derivative with a reactive thiol group, possesses antioxidant and anti-inflammatory propert …
N-acetylcysteine as an adjunctive therapy to risperidone for treatment of irritability in autism: a randomized, double-blind, placebo-controlled clinical trial of efficacy and safety.
Nikoo M, Radnia H, Farokhnia M, Mohammadi MR, Akhondzadeh S. Nikoo M, et al. Clin Neuropharmacol. 2015 Jan-Feb;38(1):11-7. doi: 10.1097/WNF.0000000000000063. Clin Neuropharmacol. 2015. PMID: 25580916 Clinical Trial.
OBJECTIVES: According to the proposed interference of N-acetylcysteine (NAC) with pathophysiologic processes of autistic disorders (ADs), we aimed to assess the effectiveness and safety of NAC as an adjunct to risperidone in the treatment of ADs in a randomiz …
OBJECTIVES: According to the proposed interference of N-acetylcysteine (NAC) with pathophysiologic processes of autistic …
A randomized controlled pilot trial of oral N-acetylcysteine in children with autism.
Hardan AY, Fung LK, Libove RA, Obukhanych TV, Nair S, Herzenberg LA, Frazier TW, Tirouvanziam R. Hardan AY, et al. Biol Psychiatry. 2012 Jun 1;71(11):956-61. doi: 10.1016/j.biopsych.2012.01.014. Epub 2012 Feb 18. Biol Psychiatry. 2012. PMID: 22342106 Free PMC article. Clinical Trial.
The goal of this pilot study was to assess the feasibility of using oral N-acetylcysteine (NAC), a glutamatergic modulator and an antioxidant, in the treatment of behavioral disturbance in children with autism. ...Compared with placebo, NAC resulted in signif …
The goal of this pilot study was to assess the feasibility of using oral N-acetylcysteine (NAC), a glutamatergic modulator and …
Antioxidant interventions in autism spectrum disorders: A meta-analysis.
Liu Y, Yang Z, Du Y, Shi S, Cheng Y. Liu Y, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2022 Mar 8;113:110476. doi: 10.1016/j.pnpbp.2021.110476. Epub 2021 Nov 15. Prog Neuropsychopharmacol Biol Psychiatry. 2022. PMID: 34793863
BACKGROUND: Autism spectrum disorder (ASD) might be associated with oxidative stress, and antioxidants are commonly used in the treatment of young people with ASD. ...RESULTS: In this meta-analysis, we examined 13 double-blind randomized clinical trials, comprising …
BACKGROUND: Autism spectrum disorder (ASD) might be associated with oxidative stress, and antioxidants are commonly used in th …
20 results