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Page 1
N-acetylcysteine Clinical Applications.
Yahia Z, Yahia A, Abdelaziz T. Yahia Z, et al. Cureus. 2024 Oct 24;16(10):e72252. doi: 10.7759/cureus.72252. eCollection 2024 Oct. Cureus. 2024. PMID: 39450216 Free PMC article. Review.
This study aims to evaluate the therapeutic application of N-acetylcysteine (NAC) as a treatment or adjunct therapy for various medical conditions. ...It may be beneficial for polycystic ovary syndrome, endometriosis, male infertility, cataracts, glaucoma, dry eye s …
This study aims to evaluate the therapeutic application of N-acetylcysteine (NAC) as a treatment or adjunct therapy for variou …
N-acetylcysteine as an adjunctive treatment for bipolar depression: A systematic review and meta-analysis of randomized controlled trials.
Nery FG, Li W, DelBello MP, Welge JA. Nery FG, et al. Bipolar Disord. 2021 Nov;23(7):707-714. doi: 10.1111/bdi.13039. Epub 2021 Jan 15. Bipolar Disord. 2021. PMID: 33354859
OBJECTIVES: Previous studies and meta-analyses suggested that N-acetylcysteine (NAC) was superior to placebo in improving depression in bipolar disorder. ...We conducted a meta-analysis to appraise the possible efficacy of NAC in treating bip …
OBJECTIVES: Previous studies and meta-analyses suggested that N-acetylcysteine (NAC) was superior to placebo in improving d …
The Multifaceted Therapeutic Role of N-Acetylcysteine (NAC) in Disorders Characterized by Oxidative Stress.
Raghu G, Berk M, Campochiaro PA, Jaeschke H, Marenzi G, Richeldi L, Wen FQ, Nicoletti F, Calverley PMA. Raghu G, et al. Curr Neuropharmacol. 2021;19(8):1202-1224. doi: 10.2174/1570159X19666201230144109. Curr Neuropharmacol. 2021. PMID: 33380301 Free PMC article. Review.
The sulfhydryl-containing tripeptide glutathione (GSH), which is synthesized and maintained at high concentrations in all cells, is one of the mechanisms by which cells protect themselves from oxidative stress. N-acetylcysteine (NAC), a synthetic derivative of the e …
The sulfhydryl-containing tripeptide glutathione (GSH), which is synthesized and maintained at high concentrations in all cells, is one of t …
N-acetylcysteine as an adjunctive treatment for bipolar depression and major depressive disorder: a systematic review and meta-analysis of double-blind, randomized placebo-controlled trials.
Kishi T, Miyake N, Okuya M, Sakuma K, Iwata N. Kishi T, et al. Psychopharmacology (Berl). 2020 Nov;237(11):3481-3487. doi: 10.1007/s00213-020-05629-2. Epub 2020 Aug 6. Psychopharmacology (Berl). 2020. PMID: 32767039
RATIONALE: It remains unclear whether using N-acetylcysteine as an adjunctive treatment has any benefit for bipolar depression and major depressive disorder. ...CONCLUSIONS: Although N-acetylcysteine decreased CGI-S score, no speci …
RATIONALE: It remains unclear whether using N-acetylcysteine as an adjunctive treatment has any benefit for bipolar …
The effect of N-acetylcysteine on bipolar depression: a systematic review and meta-analysis of randomized controlled trials.
Pittas S, Theodoridis X, Haidich AB, Bozikas PV, Papazisis G. Pittas S, et al. Psychopharmacology (Berl). 2021 Jul;238(7):1729-1736. doi: 10.1007/s00213-021-05789-9. Epub 2021 Feb 27. Psychopharmacology (Berl). 2021. PMID: 33641060
N-acetylcysteine (NAC) has been suggested as potentially effective and well-tolerated adjunctive treatment for bipolar disorder (BD). OBJECTIVES: This systematic review and meta-analysis aimed to examine the efficacy of N-acetylcysteine, …
N-acetylcysteine (NAC) has been suggested as potentially effective and well-tolerated adjunctive treatment for bipolar …
Nutrition and bipolar disorder: a systematic review.
Gabriel FC, Oliveira M, Bruna De M Martella, Berk M, Brietzke E, Jacka FN, Lafer B. Gabriel FC, et al. Nutr Neurosci. 2023 Jul;26(7):637-651. doi: 10.1080/1028415X.2022.2077031. Epub 2022 May 24. Nutr Neurosci. 2023. PMID: 35608150
INTRODUCTION: Individuals with bipolar disorder (BD) have higher rates of unhealthy lifestyles and risk for medical comorbidities Research currently suggests that dietary factors may play a role in the development of depression and anxiety. ...The 27 interven …
INTRODUCTION: Individuals with bipolar disorder (BD) have higher rates of unhealthy lifestyles and risk for medical comorbidit …
Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review.
Deepmala, Slattery J, Kumar N, Delhey L, Berk M, Dean O, Spielholz C, Frye R. Deepmala, et al. Neurosci Biobehav Rev. 2015 Aug;55:294-321. doi: 10.1016/j.neubiorev.2015.04.015. Epub 2015 May 6. Neurosci Biobehav Rev. 2015. PMID: 25957927 Free article.
N-acetylcysteine (NAC) is recognized for its role in acetaminophen overdose and as a mucolytic. ...In this systematic review we find favorable evidence for the use of NAC in several psychiatric and neurological disorders, particularly autism, Alzheimer's disease, co …
N-acetylcysteine (NAC) is recognized for its role in acetaminophen overdose and as a mucolytic. ...In this systematic review w …
Efficacy of N-acetylcysteine for patients with depression: An updated systematic review and meta-analysis.
Peng TR, Lin HH, Tseng TL, Huang YH, Tsai PY, Lin CY, Lee MC, Chen SM. Peng TR, et al. Gen Hosp Psychiatry. 2024 Nov-Dec;91:151-159. doi: 10.1016/j.genhosppsych.2024.10.018. Epub 2024 Nov 3. Gen Hosp Psychiatry. 2024. PMID: 39504621
BACKGROUND: Results on whether N-acetylcysteine (NAC) ameliorates depression in patients with psychiatric problems, such as bipolar disorder and major depressive disorder, remain inconsistent, and several new studies have recently been pu …
BACKGROUND: Results on whether N-acetylcysteine (NAC) ameliorates depression in patients with psychiatric problems, suc …
The neuroprotective effects of N-acetylcysteine in psychiatric and neurodegenerative disorders: From modulation of glutamatergic transmission to restoration of synaptic plasticity.
Chakraborty S, Shankaranarayana Rao BS, Tripathi SJ. Chakraborty S, et al. Neuropharmacology. 2025 Nov 1;278:110527. doi: 10.1016/j.neuropharm.2025.110527. Epub 2025 May 23. Neuropharmacology. 2025. PMID: 40414419 Review.
N-acetylcysteine (NAC) is an effective pleiotropic drug with a strong safety profile. ...In this review, we will be discussing in-depth mechanisms of action of NAC and its promising ability to reverse neuropathological changes, cognitive deficits and associated plas …
N-acetylcysteine (NAC) is an effective pleiotropic drug with a strong safety profile. ...In this review, we will be discussing …
Pharmacotherapies for cannabis use disorder.
Spiga F, Parkhouse T, Tang VM, Savović J, Le Foll B, Nielsen S. Spiga F, et al. Cochrane Database Syst Rev. 2025 Sep 30;9(9):CD008940. doi: 10.1002/14651858.CD008940.pub4. Cochrane Database Syst Rev. 2025. PMID: 41025421
Five studies targeted participants with comorbidities (depression (2), bipolar disorder (1), and attention deficit hyperactivity disorder (1)). ...SAE may be no more likely with THC preparations (RR 0.99, 95% CI 0.25 to 3.9; 7 studies, 584 participants …
Five studies targeted participants with comorbidities (depression (2), bipolar disorder (1), and attention deficit hype …
122 results