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Pharmacotherapies for cannabis use disorder.
Spiga F, Parkhouse T, Tang VM, Savović J, Le Foll B, Nielsen S. Spiga F, et al. Cochrane Database Syst Rev. 2025 Sep 30;9(9):CD008940. doi: 10.1002/14651858.CD008940.pub4. Cochrane Database Syst Rev. 2025. PMID: 41025421
RATIONALE: Globally, cannabis use is prevalent and widespread. There are currently no pharmacotherapies approved for the treatment of cannabis use disorder (a problematic pattern of cannabis use that leads to clinically significant impairment or distre …
RATIONALE: Globally, cannabis use is prevalent and widespread. There are currently no pharmacotherapies approved for the treatment of …
N-acetylcysteine for youth cannabis use disorder: randomized controlled trial main findings.
Gray KM, Tomko RL, Baker NL, McClure EA, McRae-Clark AL, Squeglia LM. Gray KM, et al. Neuropsychopharmacology. 2025 Apr;50(5):731-738. doi: 10.1038/s41386-025-02061-y. Epub 2025 Feb 5. Neuropsychopharmacology. 2025. PMID: 39910268 Free PMC article. Clinical Trial.
Treatment-seeking youth with cannabis use disorder (N = 192, ages 14-21) were randomized to receive a double-blind 12-week course of oral N-acetylcysteine 1200 mg or placebo twice daily; all received weekly medical management and brief behavioral couns …
Treatment-seeking youth with cannabis use disorder (N = 192, ages 14-21) were randomized to receive a double-blind 12-week cou …
Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review.
Deepmala, Slattery J, Kumar N, Delhey L, Berk M, Dean O, Spielholz C, Frye R. Deepmala, et al. Neurosci Biobehav Rev. 2015 Aug;55:294-321. doi: 10.1016/j.neubiorev.2015.04.015. Epub 2015 May 6. Neurosci Biobehav Rev. 2015. PMID: 25957927 Free article.
N-acetylcysteine (NAC) is recognized for its role in acetaminophen overdose and as a mucolytic. ...In this systematic review we find favorable evidence for the use of NAC in several psychiatric and neurological disorders, particularly autism, Alzheimer's d …
N-acetylcysteine (NAC) is recognized for its role in acetaminophen overdose and as a mucolytic. ...In this systematic review w …
Cannabis Use Disorder.
Nimmana BK, Aslam SP, Marwaha R. Nimmana BK, et al. 2026 Mar 21. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan–. 2026 Mar 21. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan–. PMID: 30844158 Free Books & Documents.
As of February 2024, the Centers for Disease Control and Prevention (CDC) reports that 47 states, the District of Columbia, and 3 territories permit some form of medical cannabis use. ...[WHO. WHO Review of Cannabis and Cannabis-Related Substances. 201 …
As of February 2024, the Centers for Disease Control and Prevention (CDC) reports that 47 states, the District of Columbia, and 3 ter …
N-acetyl cysteine in the treatment of cannabis use disorder: A systematic review of clinical trials.
Sharma R, Tikka SK, Bhute AR, Bastia BK. Sharma R, et al. Addict Behav. 2022 Jun;129:107283. doi: 10.1016/j.addbeh.2022.107283. Epub 2022 Feb 16. Addict Behav. 2022. PMID: 35189496
BACKGROUND AND AIM: Cannabis is the most consumed illicit drug globally, with a high risk of developing cannabis use disorder (CUD). ...METHODS: Systematic review of randomized controlled trials (RCTs) was conducted to determine the effect of NAC for the trea …
BACKGROUND AND AIM: Cannabis is the most consumed illicit drug globally, with a high risk of developing cannabis use disord …
The effect of N-acetylcysteine on alcohol use during a cannabis cessation trial.
Squeglia LM, Tomko RL, Baker NL, McClure EA, Book GA, Gray KM. Squeglia LM, et al. Drug Alcohol Depend. 2018 Apr 1;185:17-22. doi: 10.1016/j.drugalcdep.2017.12.005. Epub 2018 Feb 1. Drug Alcohol Depend. 2018. PMID: 29413434 Free PMC article. Clinical Trial.
N-acetylcysteine (NAC), an over-the-counter supplement, has shown promise in treating a variety of substance use disorders, but little research has evaluated its merits as a treatment for AUD. This secondary analysis from the National Drug Abuse Treatment Cli …
N-acetylcysteine (NAC), an over-the-counter supplement, has shown promise in treating a variety of substance use disorders …
Depressive symptoms and cannabis use in a placebo-controlled trial of N-Acetylcysteine for adult cannabis use disorder.
Tomko RL, Baker NL, Hood CO, Gilmore AK, McClure EA, Squeglia LM, McRae-Clark AL, Sonne SC, Gray KM. Tomko RL, et al. Psychopharmacology (Berl). 2020 Feb;237(2):479-490. doi: 10.1007/s00213-019-05384-z. Epub 2019 Nov 11. Psychopharmacology (Berl). 2020. PMID: 31712969 Free PMC article. Clinical Trial.
RATIONALE: Depression is common among individuals with cannabis use disorder (CUD), particularly individuals who present to CUD treatment. Treatments that consider this comorbidity are essential. OBJECTIVES: The goal of this secondary analysis was to examine whether …
RATIONALE: Depression is common among individuals with cannabis use disorder (CUD), particularly individuals who present to CU …
A randomized placebo-controlled trial of N-acetylcysteine for cannabis use disorder in adults.
Gray KM, Sonne SC, McClure EA, Ghitza UE, Matthews AG, McRae-Clark AL, Carroll KM, Potter JS, Wiest K, Mooney LJ, Hasson A, Walsh SL, Lofwall MR, Babalonis S, Lindblad RW, Sparenborg S, Wahle A, King JS, Baker NL, Tomko RL, Haynes LF, Vandrey RG, Levin FR. Gray KM, et al. Drug Alcohol Depend. 2017 Aug 1;177:249-257. doi: 10.1016/j.drugalcdep.2017.04.020. Epub 2017 Jun 10. Drug Alcohol Depend. 2017. PMID: 28623823 Free PMC article. Clinical Trial.
BACKGROUND: Cannabis use disorder (CUD) is a prevalent and impairing condition, and established psychosocial treatments convey limited efficacy. In light of recent findings supporting the efficacy of N-acetylcysteine (NAC) for CUD in adolescents, the o …
BACKGROUND: Cannabis use disorder (CUD) is a prevalent and impairing condition, and established psychosocial treatments convey …
Treatment of Cannabis Use Disorder: Current Science and Future Outlook.
Sherman BJ, McRae-Clark AL. Sherman BJ, et al. Pharmacotherapy. 2016 May;36(5):511-35. doi: 10.1002/phar.1747. Pharmacotherapy. 2016. PMID: 27027272 Free PMC article. Review.
Cannabis is the most commonly used illicit substance in the United States. Rates of cannabis use and cannabis use disorder (CUD) have increased in the past decade, paralleling changes in the legal and political climate favoring legalization. ...More re …
Cannabis is the most commonly used illicit substance in the United States. Rates of cannabis use and cannabis use di …
N-acetylcysteine for smoking cessation among dual users of tobacco and cannabis: Protocol and rationale for a randomized controlled trial.
Herbst ED, Pennington DL, Borsari B, Manuel J, Yalch M, Alcid E, Martinez Rivas M, Delacruz J, Rossi N, Garcia B, Wong N, Batki SL. Herbst ED, et al. Contemp Clin Trials. 2023 Aug;131:107250. doi: 10.1016/j.cct.2023.107250. Epub 2023 Jun 2. Contemp Clin Trials. 2023. PMID: 37271412 Free PMC article.
N-acetylcysteine (NAC), an FDA-approved medication and over-the-counter supplement, has shown promise in animal studies and randomized controlled trials (RCTs) in reducing tobacco and cannabis craving and use. ...To date, no RCT has examined NAC for smoking c …
N-acetylcysteine (NAC), an FDA-approved medication and over-the-counter supplement, has shown promise in animal studies and ra …
46 results