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Page 1
N-acetylcysteine for treating cocaine addiction - A systematic review.
Nocito Echevarria MA, Andrade Reis T, Ruffo Capatti G, Siciliano Soares V, da Silveira DX, Fidalgo TM. Nocito Echevarria MA, et al. Psychiatry Res. 2017 May;251:197-203. doi: 10.1016/j.psychres.2017.02.024. Epub 2017 Feb 11. Psychiatry Res. 2017. PMID: 28213190
The aim of this paper is to extensively review the current literature available on N-acetylcysteine (NAC) treatment for cocaine dependence (clinical and experimental studies). ...Four clinical studies showed NAC's capacity to reduce craving, desire to use …
The aim of this paper is to extensively review the current literature available on N-acetylcysteine (NAC) treatment for coc …
Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review.
Deepmala, Slattery J, Kumar N, Delhey L, Berk M, Dean O, Spielholz C, Frye R. Deepmala, et al. Neurosci Biobehav Rev. 2015 Aug;55:294-321. doi: 10.1016/j.neubiorev.2015.04.015. Epub 2015 May 6. Neurosci Biobehav Rev. 2015. PMID: 25957927 Free article.
N-acetylcysteine (NAC) is recognized for its role in acetaminophen overdose and as a mucolytic. ...In this systematic review we find favorable evidence for the use of NAC in several psychiatric and neurological disorders, particularly autism, Alzheimer's dise …
N-acetylcysteine (NAC) is recognized for its role in acetaminophen overdose and as a mucolytic. ...In this systematic review w …
N-acetylcysteine reduces cocaine-seeking behavior and anterior cingulate glutamate/glutamine levels among cocaine-dependent individuals.
Woodcock EA, Lundahl LH, Khatib D, Stanley JA, Greenwald MK. Woodcock EA, et al. Addict Biol. 2021 Mar;26(2):e12900. doi: 10.1111/adb.12900. Epub 2020 Mar 24. Addict Biol. 2021. PMID: 32212237 Free PMC article. Clinical Trial.
N-acetylcysteine (NAC) is a cystine prodrug shown to reduce cocaine- and cue-primed reinstatement of cocaine-seeking behavior in preclinical studies. ...Relative to the placebo priming dose, the active cocaine priming dose (110 mg) increased …
N-acetylcysteine (NAC) is a cystine prodrug shown to reduce cocaine- and cue-primed reinstatement of cocaine-see …
N-Acetylcysteine reverses cocaine-induced metaplasticity.
Moussawi K, Pacchioni A, Moran M, Olive MF, Gass JT, Lavin A, Kalivas PW. Moussawi K, et al. Nat Neurosci. 2009 Feb;12(2):182-9. doi: 10.1038/nn.2250. Epub 2009 Jan 11. Nat Neurosci. 2009. PMID: 19136971 Free PMC article.
Cocaine addiction is characterized by an impaired ability to develop adaptive behaviors that can compete with cocaine seeking, implying a deficit in the ability to induce plasticity in cortico-accumbens circuitry crucial for regulating motivated behavior. ... …
Cocaine addiction is characterized by an impaired ability to develop adaptive behaviors that can compete with cocaine s …
[Treating cocaine addiction].
Herdener M, Oppliger R, Stohler R, Caflisch C. Herdener M, et al. Praxis (Bern 1994). 2012 Aug 8;101(16):1013-9. doi: 10.1024/1661-8157/a001021. Praxis (Bern 1994). 2012. PMID: 22878944 Review. German.
Estimates assume approximately 100'000 occasional and 11'000 addicted cocaine consumers in Switzerland. Although there is no established "standard treatment", helpful pharmacological and psychotherapeutic treatment strategies for cocaine addiction and its con …
Estimates assume approximately 100'000 occasional and 11'000 addicted cocaine consumers in Switzerland. Although there is no establis …
N-Acetylcysteine reduces cocaine-cue attentional bias and differentially alters cocaine self-administration based on dosing order.
Levi Bolin B, Alcorn JL 3rd, Lile JA, Rush CR, Rayapati AO, Hays LR, Stoops WW. Levi Bolin B, et al. Drug Alcohol Depend. 2017 Sep 1;178:452-460. doi: 10.1016/j.drugalcdep.2017.05.039. Epub 2017 Jun 29. Drug Alcohol Depend. 2017. PMID: 28711811 Free PMC article.
RESULTS: Cocaine-cue attentional bias was greatest following administration of 0mg cocaine during placebo maintenance, and was attenuated by n-acetylcysteine. ...CONCLUSIONS: These results collectively suggest that a reduction in the incentive salience …
RESULTS: Cocaine-cue attentional bias was greatest following administration of 0mg cocaine during placebo maintenance, and was …
N-acetylcysteine amide (AD4) reduces cocaine-induced reinstatement.
Jastrzębska J, Frankowska M, Filip M, Atlas D. Jastrzębska J, et al. Psychopharmacology (Berl). 2016 Sep;233(18):3437-48. doi: 10.1007/s00213-016-4388-5. Epub 2016 Jul 28. Psychopharmacology (Berl). 2016. PMID: 27469021
RATIONALE: Chronic exposure to drugs of abuse changes glutamatergic transmission in human addicts and animal models. N-acetylcysteine (NAC) is a cysteine prodrug that indirectly activates cysteine-glutamate antiporters. ...In the OBX rats only, AD4 effectively block …
RATIONALE: Chronic exposure to drugs of abuse changes glutamatergic transmission in human addicts and animal models. N-acetylcyste …
N-acetylcysteine Facilitates Self-Imposed Abstinence After Escalation of Cocaine Intake.
Ducret E, Puaud M, Lacoste J, Belin-Rauscent A, Fouyssac M, Dugast E, Murray JE, Everitt BJ, Houeto JL, Belin D. Ducret E, et al. Biol Psychiatry. 2016 Aug 1;80(3):226-34. doi: 10.1016/j.biopsych.2015.09.019. Epub 2015 Oct 8. Biol Psychiatry. 2016. PMID: 26592462 Free PMC article.
BACKGROUND: N-acetylcysteine (NAC) has been suggested to prevent relapse to cocaine seeking. However, the psychological processes underlying its potential therapeutic benefit remain largely unknown. METHODS: We investigated the hallmark features of addicti …
BACKGROUND: N-acetylcysteine (NAC) has been suggested to prevent relapse to cocaine seeking. However, the psychological …
N-acetylcysteine reduces addiction-like behaviour towards high-fat high-sugar food in diet-induced obese rats.
Sketriene D, Battista D, Perry CJ, Sumithran P, Lawrence AJ, Brown RM. Sketriene D, et al. Eur J Neurosci. 2021 Aug;54(3):4877-4887. doi: 10.1111/ejn.15321. Epub 2021 Jun 17. Eur J Neurosci. 2021. PMID: 34028895
This raises the possibility that drug addiction treatments may show utility in the treatment of compulsive overeating. N-Acetylcysteine (NAC) is a cysteine pro-drug which has experienced some success in clinical trials, reducing cocaine, marijuana and …
This raises the possibility that drug addiction treatments may show utility in the treatment of compulsive overeating. N-Ac …
N-acetylcysteine Efficacy on Cocaine Base Paste Use Disorder: A Randomized Double-blind Placebo-controlled Clinical Trial.
Betancur-Moreno C, Moraga-Escobar E, Gómez C, Casanova MP, Bustos C, Vicente B. Betancur-Moreno C, et al. J Addict Med. 2025 Aug 13. doi: 10.1097/ADM.0000000000001561. Online ahead of print. J Addict Med. 2025. PMID: 40801394
OBJECTIVES: To evaluate the clinical safety and efficacy of N-acetylcysteine (NAC) in prolonging abstinence time among adults with cocaine base paste (CBP) use disorder. ...
OBJECTIVES: To evaluate the clinical safety and efficacy of N-acetylcysteine (NAC) in prolonging abstinence time among adults …
67 results