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Effects of N-acetylcysteine on rat sperm treated with hydrogen peroxide in in vitro conditions.
Zahaki Nosrat F, Yari S, Mahmoodi B, Hasanein P. Zahaki Nosrat F, et al. Biotech Histochem. 2025 Jul;100(5):303-311. doi: 10.1080/10520295.2025.2516582. Epub 2025 Jun 20. Biotech Histochem. 2025. PMID: 40539306
Oxidative stress is a significant contributor to male infertility, leading to damaged sperm. This research examines the protective effects of Nacetylcysteine (NAC) on sperm exposed to hydrogen peroxide (H2O2) induced oxidative stress in rats. ...N-acetylcy …
Oxidative stress is a significant contributor to male infertility, leading to damaged sperm. This research examines the protective ef …
Micronutrient antioxidant supplementation alleviates valproic acid-induced oxidative stress and male infertility via the NRF2/HO-1 pathway.
Asghar MA, Wan B, Li L, Zhang J, Tang S, Han H, Yang Y, Chu L, Zhang Q, Zhang X, Zhao Q. Asghar MA, et al. Redox Biol. 2025 Sep;85:103685. doi: 10.1016/j.redox.2025.103685. Epub 2025 May 29. Redox Biol. 2025. PMID: 40505349 Free PMC article.
This study explores the potential of micronutrient antioxidants to improve fertility in VPA-treated individuals. METHODS: Six-week-old male mice were treated with VPA and supplemented with antioxidants, including l-Arginine (120 mg/kg), N-Acetylcysteine (NAC) …
This study explores the potential of micronutrient antioxidants to improve fertility in VPA-treated individuals. METHODS: Six-week-ol …
Effects of N-acetyl-cysteine supplementation on sperm quality, chromatin integrity and level of oxidative stress in infertile men.
Jannatifar R, Parivar K, Roodbari NH, Nasr-Esfahani MH. Jannatifar R, et al. Reprod Biol Endocrinol. 2019 Feb 16;17(1):24. doi: 10.1186/s12958-019-0468-9. Reprod Biol Endocrinol. 2019. PMID: 30771790 Free PMC article. Clinical Trial.
BACKGROUND: Infertile men have higher levels of semen reactive oxygen species (ROS) than fertile men. High levels of semen ROS can cause sperm dysfunction, sperm DNA damage and reduced male reproductive potential. This study investigated the effects of supple …
BACKGROUND: Infertile men have higher levels of semen reactive oxygen species (ROS) than fertile men. High levels of semen ROS can ca …
Protective Effect of N-Acetylcysteine on Rooster Semen Cryopreservation.
Hakimi F, Karimi Torshizi MA, Hezavehei M, Sharafi M. Hakimi F, et al. Biopreserv Biobank. 2024 Dec;22(6):609-615. doi: 10.1089/bio.2023.0103. Epub 2024 Apr 18. Biopreserv Biobank. 2024. PMID: 38634668 Free PMC article.
However, during cooling, elevated reactive oxygen species (ROS) levels have destructive effects on both quality and function of thawed sperm. The aim of the current study is to investigate the antioxidant effects of N-acetylcysteine (NAC) during rooste …
However, during cooling, elevated reactive oxygen species (ROS) levels have destructive effects on both quality and function of thawe …
Beneficial Effects of N-Acetyl Cysteine in the Different Equilibration Times on Post-Thawed Rooster Sperm Quality.
Zanganeh Z, Hezavehei M, Halvaei I, Sharafi M. Zanganeh Z, et al. Reprod Domest Anim. 2025 Mar;60(3):e70035. doi: 10.1111/rda.70035. Reprod Domest Anim. 2025. PMID: 40056000
To improve the quality and fertility of thawed semen, it is essential to protect sperm cells from peroxidative damage. ...These findings indicate that NAC-0.1 and NAC-1 are effective in maintaining the quality of thawed rooster sperm during a 2- …
To improve the quality and fertility of thawed semen, it is essential to protect sperm cells from peroxidative damage. …
Effects of N-Acetyl Cysteine on Human Post-Thaw Sperm Quality and Mitochondrial Uncoupling Protein 2 Relative Quantity.
Dorodian P, Shahverdi A, Alizadeh A, Rashki Ghaleno L, Abbasihormozi S, Esmaeili V, Akbarinejad V, Sharafi M. Dorodian P, et al. Biopreserv Biobank. 2026 Feb;24(1):63-69. doi: 10.1089/bio.2024.0007. Epub 2026 Feb 23. Biopreserv Biobank. 2026. PMID: 40566670
Semen samples were collected from 20 normozoospermia men and were divided into four experimental groups: fresh, frozen control, frozen N-Acetylcysteine (NAC, 100 muM), and frozen negative control with Genipin (25 muM). Subsequently, post-thaw sperm quality …
Semen samples were collected from 20 normozoospermia men and were divided into four experimental groups: fresh, frozen control, frozen N …
The effect of N-acetyl cysteine consumption on men with abnormal sperm parameters due to positive history of COVID-19 in the last three months.
Rafiee B, Bagher Tabei SM. Rafiee B, et al. Arch Ital Urol Androl. 2021 Dec 21;93(4):465-467. doi: 10.4081/aiua.2021.4.465. Arch Ital Urol Androl. 2021. PMID: 34933532 Free article.
Subjects who got COVID-19 infection had a significant impairment of sperm quality (sperm concentration, sperm motility, and normal sperm morphology) compared to their semen analysis evaluated before the COVID-19 infection. NAC consumption signif …
Subjects who got COVID-19 infection had a significant impairment of sperm quality (sperm concentration, sperm mo …
Polystyrene microplastics disrupt the blood-testis barrier via CEBPB-driven lysosomal autophagy and induce ferroptosis-like injury in human sperm, compromising embryo development.
Wu M, Li L, Zhao T, Mao Y, Lin J, Li X, Bai Y, Han F, Chen S, Peng T, Liao C, Ye X, Ke H, Huang Z, Yue M, Che Y, Song Y, Chen Z, An G. Wu M, et al. J Hazard Mater. 2026 Jun 1;510:142073. doi: 10.1016/j.jhazmat.2026.142073. Epub 2026 Apr 13. J Hazard Mater. 2026. PMID: 42000504 Free article.
These alterations result in reductions in motility, DNA integrity, and early embryonic development following intracytoplasmic sperm injection (ICSI). Crucially, the antioxidant N-acetylcysteine (NAC) rescued sperm functional metrics and restored embryo …
These alterations result in reductions in motility, DNA integrity, and early embryonic development following intracytoplasmic sperm i …
Use of antioxidant could ameliorate the negative impact of etoposide on human sperm DNA during chemotherapy.
Rabaça A, Ferreira C, Bernardino R, Alves M, Oliveira P, Viana P, Barros A, Sousa M, Sá R. Rabaça A, et al. Reprod Biomed Online. 2020 Jun;40(6):856-866. doi: 10.1016/j.rbmo.2020.01.029. Epub 2020 Feb 15. Reprod Biomed Online. 2020. PMID: 32376314
RESEARCH QUESTION: A previous study showed that N-acetylcysteine (NAC), used after in-vitro exposure to the gonadotoxic chemotherapeutic drug etoposide, has the ability to decrease DNA damage in human spermatozoa; however, it showed no benefit when used befor …
RESEARCH QUESTION: A previous study showed that N-acetylcysteine (NAC), used after in-vitro exposure to the gonadotoxic chemot …
Synergistic protection of chilled canine spermatozoa by apigenin and N-acetylcysteine amide through enhanced antioxidant defense and mitochondrial function.
Heidari S, Soleimanzadeh A, Mirzaie R. Heidari S, et al. BMC Vet Res. 2026 May 8;22(1):383. doi: 10.1186/s12917-026-05538-0. BMC Vet Res. 2026. PMID: 42104342 Free PMC article.
OBJECTIVES: Semen preservation is a critical aspect of assisted reproductive technologies in canine breeding programs; however, oxidative stress during chilled storage negatively affects sperm quality by impairing motility, membrane integrity, and mitochondrial func …
OBJECTIVES: Semen preservation is a critical aspect of assisted reproductive technologies in canine breeding programs; however, oxidative st …
14 results