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Page 1
Systematic review of N-acetylcysteine in the treatment of addictions.
Asevedo E, Mendes AC, Berk M, Brietzke E. Asevedo E, et al. Braz J Psychiatry. 2014 Apr-Jun;36(2):168-75. doi: 10.1590/1516-4446-2013-1244. Epub 2014 Mar 17. Braz J Psychiatry. 2014. PMID: 24676047 Free article.
OBJECTIVE: To conduct the first systematic literature review of clinical trials of N-acetylcysteine (NAC) for the treatment of substance abuse disorders and addictive behaviors. ...These studies evaluated the role of NAC in cocaine dependence (three studies), cannab …
OBJECTIVE: To conduct the first systematic literature review of clinical trials of N-acetylcysteine (NAC) for the treatment of …
Trait Impulsivity Predicts Treatment Response in Gambling Disorder.
Chamberlain SR, Ioannidis K, Grant JE. Chamberlain SR, et al. Clin Neuropharmacol. 2025 Mar-Apr 01;48(2):27-28. doi: 10.1097/WNF.0000000000000622. Epub 2025 Jan 31. Clin Neuropharmacol. 2025. PMID: 39902830
OBJECTIVES: Impulsivity is thought to be a core feature of gambling disorder, yet little is known as to whether trait impulsivity predicts treatment response. ...Higher baseline motor impulsiveness was associated with greater treatment response ( P = 0 …
OBJECTIVES: Impulsivity is thought to be a core feature of gambling disorder, yet little is known as to whether trait impul …
N-acetylcysteine in the treatment of compulsive sexual behavior disorder: A case series.
Blum AW, Grant JE. Blum AW, et al. J Psychiatr Res. 2022 Oct;154:203-206. doi: 10.1016/j.jpsychires.2022.07.066. Epub 2022 Aug 3. J Psychiatr Res. 2022. PMID: 35952519
Although compulsive sexual behavior disorder (CSBD) is a relatively common disorder with an estimated prevalence of at least 3%, clinicians currently have limited evidence and no FDA-approved drugs to guide their treatment of this condition. N-acetylcysteine …
Although compulsive sexual behavior disorder (CSBD) is a relatively common disorder with an estimated prevalence of at least 3%, clin …
Pharmacological management of gambling disorder: an update of the literature.
Mestre-Bach G, Potenza MN. Mestre-Bach G, et al. Expert Rev Neurother. 2024 Apr;24(4):391-407. doi: 10.1080/14737175.2024.2316833. Epub 2024 Mar 1. Expert Rev Neurother. 2024. PMID: 38357896 Review.
INTRODUCTION: Gambling disorder (GD) is a mental health condition characterized by persistent and problematic betting behavior. ...The following classes of medications were considered: opioid-receptor antagonists (e.g. naltrexone and nalmefene), serotonin reuptake i …
INTRODUCTION: Gambling disorder (GD) is a mental health condition characterized by persistent and problematic betting behavior …
Trichotillomania and Skin-Picking Disorder: An Update.
Grant JE, Chamberlain SR. Grant JE, et al. Focus (Am Psychiatr Publ). 2021 Oct;19(4):405-412. doi: 10.1176/appi.focus.20210013. Epub 2021 Nov 5. Focus (Am Psychiatr Publ). 2021. PMID: 35747295 Free PMC article.
Trichotillomania and skin picking frequently co-occur, and both disorders commonly present with co-occurring depression, anxiety, impulsive, and obsessive-compulsive disorders. Behavioral therapy currently appears to be the most effective treatment for both. Pharmacotherap …
Trichotillomania and skin picking frequently co-occur, and both disorders commonly present with co-occurring depression, anxiety, impulsi …
Targeting the glutamatergic system to treat pathological gambling: current evidence and future perspectives.
Pettorruso M, De Risio L, Martinotti G, Di Nicola M, Ruggeri F, Conte G, Di Giannantonio M, Janiri L. Pettorruso M, et al. Biomed Res Int. 2014;2014:109786. doi: 10.1155/2014/109786. Epub 2014 Jun 12. Biomed Res Int. 2014. PMID: 25013755 Free PMC article. Review.
Pathological gambling or gambling disorder has been defined by the DSM-5 as a behavioral addiction. To date, its pathophysiology is not completely understood and there is no FDA-approved treatment for gambling disorders. ...Clinical trial and case series usin …
Pathological gambling or gambling disorder has been defined by the DSM-5 as a behavioral addiction. To date, its pathophysiolo …
The Potential of N-acetyl Cysteine in Behavioral Addictions and Related Compulsive and Impulsive Behaviors and Disorders: a Scoping Review.
Greenberg NR, Farhadi F, Kazer B, Potenza MN, Angarita GA. Greenberg NR, et al. Curr Addict Rep. 2022 Dec;9(4):660-670. doi: 10.1007/s40429-022-00446-3. Epub 2022 Sep 29. Curr Addict Rep. 2022. PMID: 38362235 Free PMC article.
N-acetylcysteine (NAC), a well-tolerated cysteine pro-drug and antioxidant, may reduce addictive behaviors by restoring glutamate homeostasis. The current review details and discusses the use of NAC in behavioral addictions and related impulsive and compulsiv …
N-acetylcysteine (NAC), a well-tolerated cysteine pro-drug and antioxidant, may reduce addictive behaviors by restoring glutam …
Current Understanding of Compulsive Sexual Behavior Disorder and Co-occurring Conditions: What Clinicians Should Know about Pharmacological Options.
Mestre-Bach G, Potenza MN. Mestre-Bach G, et al. CNS Drugs. 2024 Apr;38(4):255-265. doi: 10.1007/s40263-024-01075-2. Epub 2024 Mar 14. CNS Drugs. 2024. PMID: 38485889 Review.
Compulsive sexual behavior disorder (CSBD) has recently been recognized as a psychiatric disorder. Pharmacological treatments for CSBD have received little study and thus have limited empirical support. ...The main pharmacological approaches to treating CSBD have included …
Compulsive sexual behavior disorder (CSBD) has recently been recognized as a psychiatric disorder. Pharmacological treatments for CSB …
N-acetyl cysteine, a glutamate-modulating agent, in the treatment of pathological gambling: a pilot study.
Grant JE, Kim SW, Odlaug BL. Grant JE, et al. Biol Psychiatry. 2007 Sep 15;62(6):652-7. doi: 10.1016/j.biopsych.2006.11.021. Epub 2007 Apr 18. Biol Psychiatry. 2007. PMID: 17445781 Clinical Trial.
BACKGROUND: Although pathological gambling (PG) is relatively common, pharmacotherapy research for PG is limited. N-acetyl cysteine (NAC), an amino acid, seems to restore extracellular glutamate concentration in the nucleus accumbens and therefore offers promise in reducin …
BACKGROUND: Although pathological gambling (PG) is relatively common, pharmacotherapy research for PG is limited. N-acetyl cysteine ( …
Getting a Knack for NAC: N-Acetyl-Cysteine.
Sansone RA, Sansone LA. Sansone RA, et al. Innov Clin Neurosci. 2011 Jan;8(1):10-4. Innov Clin Neurosci. 2011. PMID: 21311702 Free PMC article.
N-acetyl-cysteine, N-acetylcysteine, N-acetyl cysteine, and N-acetyl-L-cysteine are all designations for the same compound, which is abbreviated as NAC. ...Because of these functions, NAC may exert a therapeutic effect on psychiatric disorders allegedly relat …
N-acetyl-cysteine, N-acetylcysteine, N-acetyl cysteine, and N-acetyl-L-cysteine are all designations for the same compo …
11 results