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72 results

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Page 1
Repression of the antiporter SLC7A11/glutathione/glutathione peroxidase 4 axis drives ferroptosis of vascular smooth muscle cells to facilitate vascular calcification.
Ye Y, Chen A, Li L, Liang Q, Wang S, Dong Q, Fu M, Lan Z, Li Y, Liu X, Ou JS, Lu L, Yan J. Ye Y, et al. Kidney Int. 2022 Dec;102(6):1259-1275. doi: 10.1016/j.kint.2022.07.034. Epub 2022 Sep 3. Kidney Int. 2022. PMID: 36063875
Additionally, GSH depletion induced by erastin (a small molecule initiating ferroptotic cell death) significantly promoted calcification of VSMCs under pro-osteogenic conditions, whereas GSH supplement by N-acetylcysteine reduced calcification of VSMCs. Consistently …
Additionally, GSH depletion induced by erastin (a small molecule initiating ferroptotic cell death) significantly promoted calcification of …
Influence of N- acetylcysteine on oxidative stress in slow-twitch soleus muscle of heart failure rats.
Martinez PF, Bonomo C, Guizoni DM, Junior SA, Damatto RL, Cezar MD, Lima AR, Pagan LU, Seiva FR, Fernandes DC, Laurindo FR, Novelli EL, Matsubara LS, Zornoff LA, Okoshi K, Okoshi MP. Martinez PF, et al. Cell Physiol Biochem. 2015;35(1):148-59. doi: 10.1159/000369683. Epub 2015 Jan 2. Cell Physiol Biochem. 2015. PMID: 25591758 Free article.
Causal or contributing factors responsible for muscle alterations have not been completely defined. This study evaluated skeletal muscle oxidative stress and NADPH oxidase activity in rats with myocardial infarction (MI) induced heart failure. ...CONCL …
Causal or contributing factors responsible for muscle alterations have not been completely defined. This study evaluated skeletal muscle …
SGLT2 expression in human vasculature and heart correlates with low-grade inflammation and causes eNOS-NO/ROS imbalance.
Mroueh A, Algara-Suarez P, Fakih W, Gong DS, Matsushita K, Park SH, Amissi S, Auger C, Kauffenstein G, Meyer N, Ohlmann P, Jesel L, Pieper MP, Marchandot B, Morel O, Mazzucotelli JP, Schini-Kerth VB. Mroueh A, et al. Cardiovasc Res. 2025 May 6;121(4):643-657. doi: 10.1093/cvr/cvae257. Cardiovasc Res. 2025. PMID: 39739876 Free article.
AIMS: Sodium-glucose co-transporter 2 inhibitors (SGLT2i) show a cardioprotective effect in heart failure and myocardial infarction, pathologies often associated with low-grade inflammation. ...The stimulatory effect of TNF-alpha was prevented by N-acetylc …
AIMS: Sodium-glucose co-transporter 2 inhibitors (SGLT2i) show a cardioprotective effect in heart failure and myocardial infar …
N-acetylcysteine reduces oxidative stress, nuclear factor-kappaB activity and cardiomyocyte apoptosis in heart failure.
Wu XY, Luo AY, Zhou YR, Ren JH. Wu XY, et al. Mol Med Rep. 2014 Aug;10(2):615-24. doi: 10.3892/mmr.2014.2292. Epub 2014 Jun 2. Mol Med Rep. 2014. PMID: 24889421 Free PMC article.
The roles of oxidative stress on nuclear factor (NF)-kappaB activity and cardiomyocyte apoptosis during heart failure were examined using the antioxidant N-acetylcysteine (NAC). Heart failure was established in Japanese whit …
The roles of oxidative stress on nuclear factor (NF)-kappaB activity and cardiomyocyte apoptosis during heart failur …
Oxidative stress in aldosteronism.
Sun Y, Ahokas RA, Bhattacharya SK, Gerling IC, Carbone LD, Weber KT. Sun Y, et al. Cardiovasc Res. 2006 Jul 15;71(2):300-9. doi: 10.1016/j.cardiores.2006.03.007. Epub 2006 Mar 13. Cardiovasc Res. 2006. PMID: 16631148 Review.
Congestive heart failure (CHF) is more than a failing heart and salt-avid state. Also present is a systemic illness which features oxidative stress in diverse tissues, a proinflammatory phenotype, and a wasting of soft tissue and bone. ...Howeve …
Congestive heart failure (CHF) is more than a failing heart and salt-avid state. Also present is a systemic illness whi …
N-acetylcysteine reduces the renal oxidative stress and apoptosis induced by hemorrhagic shock.
Moreira MA, Irigoyen MC, Saad KR, Saad PF, Koike MK, Montero EF, Martins JL. Moreira MA, et al. J Surg Res. 2016 Jun 1;203(1):113-20. doi: 10.1016/j.jss.2016.02.020. Epub 2016 Mar 2. J Surg Res. 2016. PMID: 27338542
BACKGROUND: Renal ischemia/reperfusion injury induced by hemorrhagic shock (HS) and subsequent fluid resuscitation is a common cause of acute renal failure. The objective of this study was to evaluate the effect of combining N-acetylcysteine (NAC) with fluid …
BACKGROUND: Renal ischemia/reperfusion injury induced by hemorrhagic shock (HS) and subsequent fluid resuscitation is a common cause of acut …
Enhanced oxidative stress mediates pathological autophagy and necroptosis in cardiac myocytes in pressure overload induced heart failure in rats.
Chi RF, Li L, Wang AL, Yang H, Xi J, Zhu ZF, Wang K, Li B, Yang LG, Qin FZ, Zhang C. Chi RF, et al. Clin Exp Pharmacol Physiol. 2022 Jan;49(1):60-69. doi: 10.1111/1440-1681.13583. Epub 2021 Sep 20. Clin Exp Pharmacol Physiol. 2022. PMID: 34453856
In cardiac myocytes in vitro, hydrogen peroxide induces autophagic cell death and necroptosis. Oxidative stress, myocyte autophagy and necroptosis coexist in heart failure (HF). In this study, we tested the hypothesis that excessive oxidative …
In cardiac myocytes in vitro, hydrogen peroxide induces autophagic cell death and necroptosis. Oxidative stress, myocyte autop …
Systemic inflammation and oxidative stress post-lung resection: Effect of pretreatment with N-acetylcysteine.
Bastin AJ, Davies N, Lim E, Quinlan GJ, Griffiths MJ. Bastin AJ, et al. Respirology. 2016 Jan;21(1):180-7. doi: 10.1111/resp.12662. Epub 2015 Oct 27. Respirology. 2016. PMID: 26503312 Free article. Clinical Trial.
METHODS: Eligible adults were randomized to receive preoperative infusion of N-acetylcysteine (240 mg/kg over 12 h) or placebo. Plasma thiols, interleukin-6, 8-isoprostane, ischaemia-modified albumin, red blood cell glutathione and exhaled breath condensate pH were …
METHODS: Eligible adults were randomized to receive preoperative infusion of N-acetylcysteine (240 mg/kg over 12 h) or placebo …
Carbon monoxide pollution aggravates ischemic heart failure through oxidative stress pathway.
Reboul C, Boissière J, André L, Meyer G, Bideaux P, Fouret G, Feillet-Coudray C, Obert P, Lacampagne A, Thireau J, Cazorla O, Richard S. Reboul C, et al. Sci Rep. 2017 Jan 3;7:39715. doi: 10.1038/srep39715. Sci Rep. 2017. PMID: 28045070 Free PMC article.
Instead, mitochondrial dysfunction was exacerbated leading to additional oxidative stress and Ca(2+) cycling alterations. This was reversed following acute antioxidant treatment of cardiomyocytes with N-acetylcysteine confirming involvement of CO-induc …
Instead, mitochondrial dysfunction was exacerbated leading to additional oxidative stress and Ca(2+) cycling alterations. This …
N-Acetylcysteine Influence on Oxidative Stress and Cardiac Remodeling in Rats During Transition from Compensated Left Ventricular Hypertrophy to Heart Failure.
Reyes DRA, Gomes MJ, Rosa CM, Pagan LU, Damatto FC, Damatto RL, Depra I, Campos DHS, Fernandez AAH, Martinez PF, Okoshi K, Okoshi MP. Reyes DRA, et al. Cell Physiol Biochem. 2017;44(6):2310-2321. doi: 10.1159/000486115. Epub 2017 Dec 15. Cell Physiol Biochem. 2017. PMID: 29258061 Free article.
BACKGROUND/AIMS: To evaluate the effects of the antioxidant N-acetylcysteine (NAC) on cardiac structure and function in rats with long-term ascending aortic stenosis (AS). ...NAC reduced p-ERK and p-JNK protein expression, attenuated myocardial fibrosis, and decreas …
BACKGROUND/AIMS: To evaluate the effects of the antioxidant N-acetylcysteine (NAC) on cardiac structure and function in rats w …
72 results