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Year Number of Results
1989 1
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1996 6
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1998 4
1999 5
2000 8
2001 10
2002 12
2003 8
2004 11
2005 14
2006 6
2007 10
2008 10
2009 8
2010 22
2011 10
2012 10
2013 6
2014 15
2015 24
2016 21
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374 results

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Page 1
Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review.
Deepmala, Slattery J, Kumar N, Delhey L, Berk M, Dean O, Spielholz C, Frye R. Deepmala, et al. Neurosci Biobehav Rev. 2015 Aug;55:294-321. doi: 10.1016/j.neubiorev.2015.04.015. Epub 2015 May 6. Neurosci Biobehav Rev. 2015. PMID: 25957927 Free article.
N-acetylcysteine (NAC) is recognized for its role in acetaminophen overdose and as a mucolytic. ...
N-acetylcysteine (NAC) is recognized for its role in acetaminophen overdose and as a mucolytic. ...
Activated Drp1 regulates p62-mediated autophagic flux and aggravates inflammation in cerebral ischemia-reperfusion via the ROS-RIP1/RIP3-exosome axis.
Zeng X, Zhang YD, Ma RY, Chen YJ, Xiang XM, Hou DY, Li XH, Huang H, Li T, Duan CY. Zeng X, et al. Mil Med Res. 2022 May 27;9(1):25. doi: 10.1186/s40779-022-00383-2. Mil Med Res. 2022. PMID: 35624495 Free PMC article.
METHODS: The 150 male C57 mice underwent middle cerebral artery occlusion (MCAO) for 1 h and reperfusion for 24 h, Among them, 50 MCAO mice were further treated with Mitochondrial division inhibitor 1 (Mdivi-1) and 50 MCAO mice were further treated with N-acetylcysteine …
METHODS: The 150 male C57 mice underwent middle cerebral artery occlusion (MCAO) for 1 h and reperfusion for 24 h, Among them, 50 MCAO mice …
Update on RYR1-related myopathies.
Ogasawara M, Nishino I. Ogasawara M, et al. Curr Opin Neurol. 2024 Oct 1;37(5):504-508. doi: 10.1097/WCO.0000000000001296. Epub 2024 Jul 12. Curr Opin Neurol. 2024. PMID: 38994695 Review.
RECENT FINDINGS: Although treatments such as salbutamol, pyridostigmine, and N-acetylcysteine have been explored as potential therapies for RYR1-RM, none have been conclusively proven to be effective. ...
RECENT FINDINGS: Although treatments such as salbutamol, pyridostigmine, and N-acetylcysteine have been explored as potential …
ALSUntangled #82: N-acetylcysteine.
Yerraguntla S, Bakshi B, Chandran K, Foucher J, Benatar M, Wicks P, Bedlack R, Shirilla D, Sun Y, Maragakis N, Greenstein E, Mascias Cadavid J, Rao A, Allen O, Dyckman K, Wang O, Beauchamp M, Chang V, Brown A, Carbunar O, Paganoni S, Bertorini T, Pioro E, Elsharif B, Jiang N, Pattee G, Carter G, Breevoort S, Tito E, Nathaniel G, Jackson C, Olby N, McDermott C, Ratner D, Li X. Yerraguntla S, et al. Amyotroph Lateral Scler Frontotemporal Degener. 2026 Mar 4:1-5. doi: 10.1080/21678421.2026.2638590. Online ahead of print. Amyotroph Lateral Scler Frontotemporal Degener. 2026. PMID: 41777232 Review.
While N-acetylcysteine shows theoretical promise, further research is needed to clarify its therapeutic role in ALS. At present, ALSUntangled does not support the use of N-acetylcysteine as a treatment to slow ALS progression....
While N-acetylcysteine shows theoretical promise, further research is needed to clarify its therapeutic role in ALS. At presen …
Tau is required for glial lipid droplet formation and resistance to neuronal oxidative stress.
Goodman LD, Ralhan I, Li X, Lu S, Moulton MJ, Park YJ, Zhao P, Kanca O, Ghaderpour Taleghani ZS, Jacquemyn J, Shulman JM, Ando K, Sun K, Ioannou MS, Bellen HJ. Goodman LD, et al. Nat Neurosci. 2024 Oct;27(10):1918-1933. doi: 10.1038/s41593-024-01740-1. Epub 2024 Aug 26. Nat Neurosci. 2024. PMID: 39187706 Free PMC article.
Behaviorally, flies lacking glial Tau have decreased lifespans and motor defects that are rescuable by administering the antioxidant N-acetylcysteine amide. Overall, this work provides insights into the important role that Tau has in glia to mitigate ROS in the brai …
Behaviorally, flies lacking glial Tau have decreased lifespans and motor defects that are rescuable by administering the antioxidant N …
Recent advances in the treatment of primary and secondary progressive Multiple Sclerosis.
Sriwastava S, Elkhooly M, Amatya S, Shrestha K, Kagzi Y, Bhatia D, Gupta R, Jaiswal S, Lisak RP. Sriwastava S, et al. J Neuroimmunol. 2024 May 15;390:578315. doi: 10.1016/j.jneuroim.2024.578315. Epub 2024 Feb 17. J Neuroimmunol. 2024. PMID: 38554666 Review.
Vidofludimus calcium, an orally available treatment, has shown a reduction of active and new MRI lesions. Other treatments like simvastatin, N-acetylcysteine (NAC), and alpha-lipoic acid are being explored for their antioxidant properties. ...
Vidofludimus calcium, an orally available treatment, has shown a reduction of active and new MRI lesions. Other treatments like simvastatin, …
Reactivating PTEN to impair glioma stem cells by inhibiting cytosolic iron-sulfur assembly.
Yin J, Ge X, Ding F, He L, Song K, Shi Z, Ge Z, Zhang J, Ji J, Wang X, Zhao N, Shu C, Lin F, Wang Q, Zhou Q, Cao Y, Liu W, Ye D, Rich JN, Wang X, You Y, Qian X. Yin J, et al. Sci Transl Med. 2024 Mar 20;16(739):eadg5553. doi: 10.1126/scitranslmed.adg5553. Epub 2024 Mar 20. Sci Transl Med. 2024. PMID: 38507470
Functionally, inhibiting PTEN C211 succination by reexpressing a PTEN C211S mutant, depleting ADSL by shRNAs, or consuming fumarate by the US Food and Drug Administration-approved prescription drug N-acetylcysteine (NAC) impaired GSC maintenance. Reexpressing PTEN C …
Functionally, inhibiting PTEN C211 succination by reexpressing a PTEN C211S mutant, depleting ADSL by shRNAs, or consuming fumarate by the U …
Abandon the NAC in α-synuclein.
Goedert M, Griesinger C, Outeiro TF, Riek R, Schröder GF, Spillantini MG. Goedert M, et al. Lancet Neurol. 2024 Jul;23(7):669. doi: 10.1016/S1474-4422(24)00176-5. Lancet Neurol. 2024. PMID: 38876744 No abstract available.
Modulation of Brain Kynurenic Acid by N-Acetylcysteine Prevents Cognitive Impairment and Muscular Weakness Induced by Cisplatin in Female Rats.
Dorcas Aremu T, Ramírez Ortega D, Blanco Ayala T, González Esquivel DF, Pineda B, Pérez de la Cruz G, Salazar A, Flores I, Meza-Sosa KF, Sánchez Chapul L, Rangel-López E, Gómez-Manzo S, Márquez Navarro A, Roldán Roldán G, Pérez de la Cruz V. Dorcas Aremu T, et al. Cells. 2024 Dec 2;13(23):1989. doi: 10.3390/cells13231989. Cells. 2024. PMID: 39682737 Free PMC article.
This study aimed to evaluate the effects of modulating brain KYNA levels by the administration of N-acetylcysteine (NAC), an inhibitor of kynurenine aminotransferase II (KATII), an enzyme responsible for KYNA biosynthesis on the cognitive and neuromuscular deficits …
This study aimed to evaluate the effects of modulating brain KYNA levels by the administration of N-acetylcysteine (NAC), an i …
N-Acetylcysteine for Hereditary Cystatin C Amyloid Angiopathy: A Nonrandomized Clinical Trial.
Snorradottir AO, Gutierrez-Uzquiza A, Bragado P, March ME, Kao C, Arkink EB, Jonsdottir S, Sigurdardottir A, Isaksson HJ, Mariasdóttir HL, Bjorgvinsdottir OY, Kowal NM, Heimisdottir HL, Sverrisdottir A, Palsdottir A, Bjornsson HT, Hakonarson H. Snorradottir AO, et al. JAMA Neurol. 2025 May 1;82(5):486-494. doi: 10.1001/jamaneurol.2025.0326. JAMA Neurol. 2025. PMID: 40163249 Free PMC article. Clinical Trial.
OBJECTIVE: To investigate safety, tolerance, and therapeutic potential of N-acetylcysteine (NAC) in lowering disease-associated biomarkers in sequence variation carriers. ...
OBJECTIVE: To investigate safety, tolerance, and therapeutic potential of N-acetylcysteine (NAC) in lowering disease-associate …
374 results