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1985 1
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65 results

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Page 1
Nitrate tolerance: the lack of effect of N-acetylcysteine.
Parker JO, Farrell B, Lahey KA, Rose BF. Parker JO, et al. Circulation. 1987 Sep;76(3):572-6. doi: 10.1161/01.cir.76.3.572. Circulation. 1987. PMID: 3304705 Clinical Trial.
During sustained therapy there was attenuation of the hemodynamic effects at rest, and treadmill exercise time to the onset of angina and to the development of moderate angina was increased 1 hr after dosing; no effect was apparent at 3 hr. During this state of nitrate …
During sustained therapy there was attenuation of the hemodynamic effects at rest, and treadmill exercise time to the onset of angina and to …
Chronic administration of N-acetylcysteine fails to prevent nitrate tolerance in patients with stable angina pectoris.
Hogan JC, Lewis MJ, Henderson AH. Hogan JC, et al. Br J Clin Pharmacol. 1990 Oct;30(4):573-7. doi: 10.1111/j.1365-2125.1990.tb03815.x. Br J Clin Pharmacol. 1990. PMID: 2127226 Free PMC article. Clinical Trial.
Reduced availability of sulphydryl groups in vascular smooth muscle cells may contribute to the development of tolerance to the action of the organic nitrovasodilators. 2. Eight patients with stable angina were treated with 10 mg of transdermal glyceryl trinitrate per 24 h …
Reduced availability of sulphydryl groups in vascular smooth muscle cells may contribute to the development of tolerance to the actio …
Physiological and performance effects of dietary nitrate and N-acetylcysteine supplementation during prolonged heavy-intensity cycling.
Tan R, Black M, Home J, Blackwell J, Clark I, Wylie L, Vanhatalo A, Jones AM. Tan R, et al. J Sports Sci. 2022 Dec;40(23):2585-2594. doi: 10.1080/02640414.2023.2176052. Epub 2023 Feb 9. J Sports Sci. 2022. PMID: 36759944 Free article.
The purpose of this study was to investigate effects of concurrent and independent administration of dietary nitrate (NO(3)(-)), administered as NO(3)(-)-rich beetroot juice (BR; ~12.4 mmol of NO(3)(-)), and N-acetylcysteine (NAC; 70 mg.kg(-1)) on physiologic …
The purpose of this study was to investigate effects of concurrent and independent administration of dietary nitrate (NO(3)(-)), admi …
Continuous oral N-acetylcysteine treatment and development of nitrate tolerance in patients with stable angina pectoris.
Boesgaard S, Aldershvile J, Pedersen F, Pietersen A, Madsen JK, Grande P. Boesgaard S, et al. J Cardiovasc Pharmacol. 1991 Jun;17(6):889-93. doi: 10.1097/00005344-199106000-00005. J Cardiovasc Pharmacol. 1991. PMID: 1714011 Clinical Trial.
The presence of sulfhydryl (SH) groups appears to be fundamental to nitrate-induced vasodilation and N-acetylcysteine (NAC), a sulfhydryl (SH)-donor substance, potentiates hemodynamic responsiveness to nitrates. ...This finding may suggest that develop …
The presence of sulfhydryl (SH) groups appears to be fundamental to nitrate-induced vasodilation and N-acetylcysteine ( …
Nitrate tolerance in epicardial arteries or in the venous system is not reversed by N-acetylcysteine in vivo, but tolerance-independent interactions exist.
Münzel T, Holtz J, Mülsch A, Stewart DJ, Bassenge E. Münzel T, et al. Circulation. 1989 Jan;79(1):188-97. doi: 10.1161/01.cir.79.1.188. Circulation. 1989. PMID: 2562937
N-acetylcysteine is assumed to reverse nitrate tolerance by replenishing depleted intracellular sulfhydryl groups, but data on interactions of N-acetylcysteine and nitrates in patients with stable angina are controversial and disap …
N-acetylcysteine is assumed to reverse nitrate tolerance by replenishing depleted intracellular sulfhydryl group …
[Nitrate tolerance and its management by N-acetylcysteine (studies of patients with severe chronic heart failure)].
Bodemann T, Langescheid C, Hochrein H. Bodemann T, et al. Z Kardiol. 1989 May;78(5):328-34. Z Kardiol. 1989. PMID: 2499991 German.
The mechanisms responsible for the development of nitrate tolerance are not completely clear, and their clinical importance remains controversial. This study examined the possible development of nitrate tolerance under the continuous infusion of high d …
The mechanisms responsible for the development of nitrate tolerance are not completely clear, and their clinical importance re …
Inhibition of development of tolerance to nitroglycerin by preventive administration of N-acetylcysteine in rats.
Tsuneyoshi H, Akatsuka N, Ohno M, Hara K, Ochiai M, Moroi M. Tsuneyoshi H, et al. Jpn Heart J. 1989 Sep;30(5):733-41. doi: 10.1536/ihj.30.733. Jpn Heart J. 1989. PMID: 2515322
The efficacy of N-acetylcysteine in reversing nitrate tolerance has been controversial. This study examined whether continuous administration of N-acetylcysteine, a sulfhydryl compound, can prevent the development of tolerance to n …
The efficacy of N-acetylcysteine in reversing nitrate tolerance has been controversial. This study examined whet …
N-acetylcysteine fails to attenuate haemodynamic tolerance to glyceryl trinitrate in healthy volunteers.
Hogan JC, Lewis MJ, Henderson AH. Hogan JC, et al. Br J Clin Pharmacol. 1989 Oct;28(4):421-6. doi: 10.1111/j.1365-2125.1989.tb03522.x. Br J Clin Pharmacol. 1989. PMID: 2511910 Free PMC article. Clinical Trial.
1. The effects of chronic dosing with N-acetylcysteine (NAC), on nitrate-induced haemodynamic changes during the acute and chronic treatment of healthy volunteers with glyceryl trinitrate (GTN) patches (Transiderm nitro) has been investigated. 2. ...By day 4 …
1. The effects of chronic dosing with N-acetylcysteine (NAC), on nitrate-induced haemodynamic changes during the acute …
Nitrate tolerance. A review of the evidence.
Flaherty JT. Flaherty JT. Drugs. 1989 Apr;37(4):523-50. doi: 10.2165/00003495-198937040-00006. Drugs. 1989. PMID: 2661197 Review.
However, attenuation of, or tolerance to, haemodynamic and anti-ischaemic effects may occur with all long-acting nitrate formulations. ...Means of avoiding attenuation may include the coadministration of sulfhydryl donors such as N-acetylcysteine. Alte …
However, attenuation of, or tolerance to, haemodynamic and anti-ischaemic effects may occur with all long-acting nitrate formu …
65 results