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1985 1
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94 results

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Page 1
The Role of N-Acetylcysteine in Platelet Aggregation and Reperfusion Injury in Recent Years.
Nikbakht M, Ahmadi F, Vaseghi G, Talasaz AH, Eshraghi A, Naderi J, Daneshmehr MA. Nikbakht M, et al. Curr Clin Pharmacol. 2017;12(2):83-91. doi: 10.2174/1574884712666170704145842. Curr Clin Pharmacol. 2017. PMID: 28676007 Review.
BACKGROUND: N-acetylcysteine (NAC) is an amino acid that contains a cysteine group and is currently used widely in various fields of medical research especially in cardiology. ...Key words used as search terms included "N-acetylcysteine", "platelet …
BACKGROUND: N-acetylcysteine (NAC) is an amino acid that contains a cysteine group and is currently used widely in various fie …
N-acetylcysteine Amide AD4/NACA and Thioredoxin Mimetic Peptides Inhibit Platelet Aggregation and Protect against Oxidative Stress.
Eligini S, Munno M, Atlas D, Banfi C. Eligini S, et al. Antioxidants (Basel). 2023 Jul 7;12(7):1395. doi: 10.3390/antiox12071395. Antioxidants (Basel). 2023. PMID: 37507934 Free PMC article.
In the present study, we tested the effect of small-molecular-weight redox molecules on collagen-induced platelet aggregation. We used N-acetylcysteine amide (AD4/NACA), the amide form of N-acetylcysteine (NAC), a thiol antioxidant with i …
In the present study, we tested the effect of small-molecular-weight redox molecules on collagen-induced platelet aggregation. …
N-Acetylcysteine Inhibits Platelet Function through the Regeneration of the Non-Oxidative Form of Albumin.
Eligini S, Porro B, Aldini G, Colli S, Banfi C. Eligini S, et al. Antioxidants (Basel). 2022 Feb 23;11(3):445. doi: 10.3390/antiox11030445. Antioxidants (Basel). 2022. PMID: 35326096 Free PMC article.
N-acetylcysteine (NAC) is able to break down protein disulfides, generating free thiols. ...In our conditions, the exposure of platelets to NAC did not increase GSH levels. However, the inhibition of platelet aggregation was also detected following tre …
N-acetylcysteine (NAC) is able to break down protein disulfides, generating free thiols. ...In our conditions, the exposure of …
N-Acetylcysteine potentiates inhibition of platelet aggregation by nitroglycerin.
Loscalzo J. Loscalzo J. J Clin Invest. 1985 Aug;76(2):703-8. doi: 10.1172/JCI112024. J Clin Invest. 1985. PMID: 2863286 Free PMC article.
Because the in vivo action of nitroglycerin on smooth muscle cells has been shown to depend on the presence of reduced cytosolic sulfhydryl groups, the inhibitory effect of nitroglycerin on platelet aggregation was examined in the presence of the reduced thiol, N …
Because the in vivo action of nitroglycerin on smooth muscle cells has been shown to depend on the presence of reduced cytosolic sulfhydryl …
N-Acetylcysteine potentiates nitroglycerin-induced reversal of platelet aggregation.
Chirkov YY, Horowitz JD. Chirkov YY, et al. J Cardiovasc Pharmacol. 1996 Sep;28(3):375-80. doi: 10.1097/00005344-199609000-00005. J Cardiovasc Pharmacol. 1996. PMID: 8877583
N-Acetylcysteine (N-AC) potentiates the systemic and coronary hemodynamic and antianginal effects of nitroglycerin (NGT) in humans; NTG/N-AC reduces the incidence of acute myocardial infarction in patients with unstable angina pectoris. ...NTG, added to plate …
N-Acetylcysteine (N-AC) potentiates the systemic and coronary hemodynamic and antianginal effects of nitroglycerin (NGT …
N-acetylcysteine attenuates systemic platelet activation and cerebral vessel thrombosis in diabetes.
Wang B, Yee Aw T, Stokes KY. Wang B, et al. Redox Biol. 2018 Apr;14:218-228. doi: 10.1016/j.redox.2017.09.005. Epub 2017 Sep 20. Redox Biol. 2018. PMID: 28961512 Free PMC article.
OBJECTIVE: We previously demonstrated that diabetes exacerbates stroke-induced brain injury, and that this correlates with brain methylglyoxal (MG)-to-glutathione (GSH) status. Cerebral injury was reversed by N-acetylcysteine (NAC). Here we tested if the pro-thrombo …
OBJECTIVE: We previously demonstrated that diabetes exacerbates stroke-induced brain injury, and that this correlates with brain methylglyox …
Hump-Nosed Pit Viper (Hypnale hypnale) Venom-Induced Irreversible Red Blood Cell Aggregation, Inhibition by Monovalent Anti-Venom and N-Acetylcysteine.
Sandesha VD, Naveen P, Manikanta K, Mahalingam SS, Girish KS, Kemparaju K. Sandesha VD, et al. Cells. 2024 Jun 7;13(12):994. doi: 10.3390/cells13120994. Cells. 2024. PMID: 38920625 Free PMC article.
Venom-induced RBC aggregates exhibited pro-coagulant activity but without affecting platelet aggregation. In pre-incubation or co-treatment studies, none of the bioactive compounds, such as melatonin, curcumin, fisetin, berberine, and quercetin, sugars such as manno …
Venom-induced RBC aggregates exhibited pro-coagulant activity but without affecting platelet aggregation. In pre-incubation or …
N-acetylcysteine potentiates platelet inhibition by endothelium-derived relaxing factor.
Stamler J, Mendelsohn ME, Amarante P, Smick D, Andon N, Davies PF, Cooke JP, Loscalzo J. Stamler J, et al. Circ Res. 1989 Sep;65(3):789-95. doi: 10.1161/01.res.65.3.789. Circ Res. 1989. PMID: 2548765 Free article.
Endothelial cells stimulated with bradykinin or exposed to stirred medium expressed a dose-dependent inhibition of platelet aggregation that was potentiated by the reduced thiol, N-acetylcysteine. Endothelial cell-mediated platelet inhibition wa …
Endothelial cells stimulated with bradykinin or exposed to stirred medium expressed a dose-dependent inhibition of platelet aggreg …
Glyceryl trinitrate and platelet aggregation: effects of N-acetyl-cysteine.
Hogan JC, Lewis MJ, Henderson AH. Hogan JC, et al. Br J Clin Pharmacol. 1989 May;27(5):617-9. doi: 10.1111/j.1365-2125.1989.tb03425.x. Br J Clin Pharmacol. 1989. PMID: 2503018 Free PMC article. Clinical Trial.
This action is potentiated by the sulphydryl donor N-acetylcysteine. We have investigated the effects of GTN given with and without N-acetylcysteine on ex vivo platelet aggregation in man. In a double-blind randomised crossover trial eigh …
This action is potentiated by the sulphydryl donor N-acetylcysteine. We have investigated the effects of GTN given with and wi …
N-acetylcysteine administration improves platelet aggregation in hypoxia-reoxygenation injury.
Chan E, Obaid L, Johnson ST, Bigam DL, Cheung PY. Chan E, et al. Proc West Pharmacol Soc. 2007;50:53-7. Proc West Pharmacol Soc. 2007. PMID: 18605229
Platelet aggregation was significantly reduced with a rightward shift of concentration-response curve. ...In a newborn piglet model of asphyxia and reoxygenation, NAC treatment effectively improves platelet aggregation when given upon resuscitation....
Platelet aggregation was significantly reduced with a rightward shift of concentration-response curve. ...In a newborn piglet …
94 results