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49 results

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Page 1
The Potential of N-Acetyl-L-Cysteine (NAC) in the Treatment of Psychiatric Disorders.
Bradlow RCJ, Berk M, Kalivas PW, Back SE, Kanaan RA. Bradlow RCJ, et al. CNS Drugs. 2022 May;36(5):451-482. doi: 10.1007/s40263-022-00907-3. Epub 2022 Mar 22. CNS Drugs. 2022. PMID: 35316513 Free PMC article. Review.
Primarily through its antioxidant, anti-inflammatory, and glutamate modulation activity, NAC has been investigated in the treatment of neurodevelopmental disorders, schizophrenia spectrum disorders, bipolar-related disorders, depressive disorders, anxiety disorders, obsess …
Primarily through its antioxidant, anti-inflammatory, and glutamate modulation activity, NAC has been investigated in the treatment of neuro …
N-Acetylcysteine (NAC) in Schizophrenia Resistant to Clozapine: A Double-Blind, Randomized, Placebo-Controlled Trial Targeting Negative Symptoms.
Neill E, Rossell SL, Yolland C, Meyer D, Galletly C, Harris A, Siskind D, Berk M, Bozaoglu K, Dark F, Dean OM, Francis PS, Liu D, Phillipou A, Sarris J, Castle DJ. Neill E, et al. Schizophr Bull. 2022 Nov 18;48(6):1263-1272. doi: 10.1093/schbul/sbac065. Schizophr Bull. 2022. PMID: 35857752 Free PMC article. Clinical Trial.
There is a need for adjunct treatments to augment clozapine, notably for negative and cognitive symptoms. One such potential agent is the glutathione precursor N-acetylcysteine (NAC). ...CONCLUSIONS: NAC did not significantly improve schizophrenia …
There is a need for adjunct treatments to augment clozapine, notably for negative and cognitive symptoms. One such potential a …
Improvement of cognitive function in schizophrenia with N-acetylcysteine: A theoretical review.
Yolland COB, Phillipou A, Castle DJ, Neill E, Hughes ME, Galletly C, Smith ZM, Francis PS, Dean OM, Sarris J, Siskind D, Harris AWF, Rossell SL. Yolland COB, et al. Nutr Neurosci. 2020 Feb;23(2):139-148. doi: 10.1080/1028415X.2018.1478766. Epub 2018 May 30. Nutr Neurosci. 2020. PMID: 29847303 Review.
Objectives: Schizophrenia is a debilitating psychiatric illness associated with positive and negative symptoms as well as significant impairments in cognition. ...Increased oxidative stress and altered antioxidant levels, including glutathione (GSH) have been …
Objectives: Schizophrenia is a debilitating psychiatric illness associated with positive and negative symptoms as well …
N-acetylcysteine enhances the antipsychotic effect of aripiprazole in the neurodevelopmental rat model of schizophrenia.
Rogóż Z, Kamińska K, Wąsik A. Rogóż Z, et al. Pharmacol Biochem Behav. 2025 Jul;252:174028. doi: 10.1016/j.pbb.2025.174028. Epub 2025 Apr 30. Pharmacol Biochem Behav. 2025. PMID: 40316146
In addition, therapy of negative symptoms and cognitive deficits in schizophrenic patients is a serious clinical problem. Some clinical studies have shown that the atypical antipsychotic drug aripiprazole (ARI), and the antioxidant N-acetylcysteine (NA …
In addition, therapy of negative symptoms and cognitive deficits in schizophrenic patients is a serious clinical problem. Some …
Antipsychotic Augmentation With N-Acetylcysteine for Patients With Schizophrenia.
Andrade C. Andrade C. J Clin Psychiatry. 2022 Sep 26;83(5):22f14664. doi: 10.4088/JCP.22f14664. J Clin Psychiatry. 2022. PMID: 36170201 Free article.
N-acetylcysteine (NAC) augmentation of antipsychotic medication is one of very many antipsychotic augmentation strategies that have been studied in schizophrenia. ...Important findings not influenced by the 2 outlying RCTs were significant attenuation by NAC …
N-acetylcysteine (NAC) augmentation of antipsychotic medication is one of very many antipsychotic augmentation strategies that …
Antipsychotic-minocycline-acetylcysteine combination for positive, cognitive, and negative symptoms of schizophrenia.
Koola MM. Koola MM. Asian J Psychiatr. 2019 Feb;40:100-102. doi: 10.1016/j.ajp.2019.02.007. Epub 2019 Feb 12. Asian J Psychiatr. 2019. PMID: 30776665
Preclinical evidence shows that the minocycline and N-acetylcysteine (NAC) combination synergistically improved cognition. Meta-analyses of randomized controlled trials (RCTs) with minocycline and NAC have shown some efficacy signal for positive, cognitive, and n …
Preclinical evidence shows that the minocycline and N-acetylcysteine (NAC) combination synergistically improved cognition. Met …
N-Acetylcysteine effects on glutathione and glutamate in schizophrenia: A preliminary MRS study.
Yang YS, Maddock RJ, Zhang H, Lee J, Hellemann G, Marder SR, Green MF. Yang YS, et al. Psychiatry Res Neuroimaging. 2022 Sep;325:111515. doi: 10.1016/j.pscychresns.2022.111515. Epub 2022 Jun 23. Psychiatry Res Neuroimaging. 2022. PMID: 35839558 Clinical Trial.
N-acetylcysteine (NAC) is a commonly used antioxidant that may have beneficial effects for schizophrenia. ...We also observed a baseline association between medial prefrontal cortex levels of glutathione and plasma reduced / oxidized glutathione ratios. No tr …
N-acetylcysteine (NAC) is a commonly used antioxidant that may have beneficial effects for schizophrenia. ...We also ob …
Meta-analysis of randomised controlled trials with N-acetylcysteine in the treatment of schizophrenia.
Yolland CO, Hanratty D, Neill E, Rossell SL, Berk M, Dean OM, Castle DJ, Tan EJ, Phillipou A, Harris AW, Barreiros AR, Hansen A, Siskind D. Yolland CO, et al. Aust N Z J Psychiatry. 2020 May;54(5):453-466. doi: 10.1177/0004867419893439. Epub 2019 Dec 11. Aust N Z J Psychiatry. 2020. PMID: 31826654
Positive and Negative Syndrome Scale negative and total scores were significantly improved in the N-acetylcysteine group after 24 weeks of treatment. The cognitive domain of working memory improved with N-acetylcysteine supplementation. C …
Positive and Negative Syndrome Scale negative and total scores were significantly improved in the N-acetylcysteine …
Recycling N-acetylcysteine: A review of evidence for adjunctive therapy in schizophrenia.
Willborn RJ, Hall CP, Fuller MA. Willborn RJ, et al. Ment Health Clin. 2019 May 10;9(3):116-123. doi: 10.9740/mhc.2019.05.116. eCollection 2019 May. Ment Health Clin. 2019. PMID: 31123658 Free PMC article.
INTRODUCTION: All symptoms in schizophrenia may impact functioning. Although Food and Drug Administration-approved medications typically benefit positive symptoms, negative symptoms are generally refractory to medication interventions. N- …
INTRODUCTION: All symptoms in schizophrenia may impact functioning. Although Food and Drug Administration-approved medications …
N-acetylcysteine as an adjunct to risperidone for treatment of negative symptoms in patients with chronic schizophrenia: a randomized, double-blind, placebo-controlled study.
Farokhnia M, Azarkolah A, Adinehfar F, Khodaie-Ardakani MR, Hosseini SM, Yekehtaz H, Tabrizi M, Rezaei F, Salehi B, Sadeghi SM, Moghadam M, Gharibi F, Mirshafiee O, Akhondzadeh S. Farokhnia M, et al. Clin Neuropharmacol. 2013 Nov-Dec;36(6):185-92. doi: 10.1097/WNF.0000000000000001. Clin Neuropharmacol. 2013. PMID: 24201233 Clinical Trial.
N-Acetylcysteine (NAC) is a potent antioxidant with neuroprotective properties. This study aimed to evaluate the possible effects of NAC as an adjunct to risperidone in treating negative symptoms of schizophrenia. ...CONCLUSIONS: NAC add-on ther …
N-Acetylcysteine (NAC) is a potent antioxidant with neuroprotective properties. This study aimed to evaluate the possible effe …
49 results