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Effects of N-acetylcysteine on rat sperm treated with hydrogen peroxide in in vitro conditions.
Zahaki Nosrat F, Yari S, Mahmoodi B, Hasanein P. Zahaki Nosrat F, et al. Biotech Histochem. 2025 Jul;100(5):303-311. doi: 10.1080/10520295.2025.2516582. Epub 2025 Jun 20. Biotech Histochem. 2025. PMID: 40539306
Oxidative stress is a significant contributor to male infertility, leading to damaged sperm. This research examines the protective effects of Nacetylcysteine (NAC) on sperm exposed to hydrogen peroxide (H2O2) induced oxidative stress in rats. ...N …
Oxidative stress is a significant contributor to male infertility, leading to damaged sperm. This research examines the …
Micronutrient antioxidant supplementation alleviates valproic acid-induced oxidative stress and male infertility via the NRF2/HO-1 pathway.
Asghar MA, Wan B, Li L, Zhang J, Tang S, Han H, Yang Y, Chu L, Zhang Q, Zhang X, Zhao Q. Asghar MA, et al. Redox Biol. 2025 Sep;85:103685. doi: 10.1016/j.redox.2025.103685. Epub 2025 May 29. Redox Biol. 2025. PMID: 40505349 Free PMC article.
BACKGROUND: Valproic Acid (VPA), a widely used anticonvulsant, is known to induce oxidative stress, contributing to male infertility. This study explores the potential of micronutrient antioxidants to improve fertility in VPA-treated individuals. METHODS: Six-week-o …
BACKGROUND: Valproic Acid (VPA), a widely used anticonvulsant, is known to induce oxidative stress, contributing to male infertili …
Effects of N-acetyl-cysteine supplementation on sperm quality, chromatin integrity and level of oxidative stress in infertile men.
Jannatifar R, Parivar K, Roodbari NH, Nasr-Esfahani MH. Jannatifar R, et al. Reprod Biol Endocrinol. 2019 Feb 16;17(1):24. doi: 10.1186/s12958-019-0468-9. Reprod Biol Endocrinol. 2019. PMID: 30771790 Free PMC article. Clinical Trial.
BACKGROUND: Infertile men have higher levels of semen reactive oxygen species (ROS) than fertile men. High levels of semen ROS can cause sperm dysfunction, sperm DNA damage and reduced male reproductive potential. This study investigated the effects of supple …
BACKGROUND: Infertile men have higher levels of semen reactive oxygen species (ROS) than fertile men. High levels of semen ROS can cause …
Association of heat shock protein A2 expression and sperm quality after N-acetyl-cysteine supplementation in astheno-terato-zoospermic infertile men.
Jannatifar R, Cheraghi E, Nasr-Esfahani MH, Piroozmanesh H. Jannatifar R, et al. Andrologia. 2021 Jun;53(5):e14024. doi: 10.1111/and.14024. Epub 2021 Mar 4. Andrologia. 2021. PMID: 33661545
In infertile men, reduced expression of heat shock protein A2 (HSPA2) is related to reduced sperm quality and function. The present study has aimed to investigate the effects of N-acetyl-cysteine (NAC) supplementation on expression of heat shock protein A2 (HSPA2). …
In infertile men, reduced expression of heat shock protein A2 (HSPA2) is related to reduced sperm quality and function. The pr …
Effect of Antioxidants on Sperm Quality Parameters in Subfertile Men: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.
Su L, Qu H, Cao Y, Zhu J, Zhang SZ, Wu J, Jiao YZ. Su L, et al. Adv Nutr. 2022 Mar;13(2):586-594. doi: 10.1093/advances/nmab127. Epub 2023 Feb 10. Adv Nutr. 2022. PMID: 34694345 Free PMC article.
However, the effectiveness of different antioxidants in improving sperm quality remains unclear. In this study, a network meta-analysis (NMA) was designed to evaluate the effects of different antioxidants on sperm quality parameters in subfertile men. …
However, the effectiveness of different antioxidants in improving sperm quality remains unclear. In this study, a network meta …
Unlocking the potential of antioxidant supplementation with n-acetylcysteine to improve seminal parameters and analysis of its safety: a systematic review and meta-analysis of randomized controlled trials.
Syarif S, Makkaraka MAG, Zainal ATF, Birowo P, Atmoko W. Syarif S, et al. Arch Ital Urol Androl. 2025 Mar 28;97(1):13750. doi: 10.4081/aiua.2025.13750. Epub 2025 Mar 24. Arch Ital Urol Androl. 2025. PMID: 40126496 Free article.
A literature search across PubMed, ScienceDirect, Cochrane Library and Scopus on February 21, 2024 of studies evaluating NAC supplementation for male infertility or impaired semen parameters was conducted. Study quality was assessed using Revised Cochrane's r …
A literature search across PubMed, ScienceDirect, Cochrane Library and Scopus on February 21, 2024 of studies evaluating NAC supplementation …
Endocrine disruptor chemicals. A review of their effects on male reproduction and antioxidants as a strategy to counter it.
Quilaqueo N, Villegas JV. Quilaqueo N, et al. Andrologia. 2022 Mar;54(2):e14302. doi: 10.1111/and.14302. Epub 2021 Nov 11. Andrologia. 2022. PMID: 34761829 Review.
Endocrine disruptor chemicals generate transgenerational epigenetic problems, besides being associated with male infertility. Epidemiological data indicate that the increase in reproductive problems in males in the last 50 years is correlated with the increase of en …
Endocrine disruptor chemicals generate transgenerational epigenetic problems, besides being associated with male infertility. …
The effect of N-acetyl cysteine consumption on men with abnormal sperm parameters due to positive history of COVID-19 in the last three months.
Rafiee B, Bagher Tabei SM. Rafiee B, et al. Arch Ital Urol Androl. 2021 Dec 21;93(4):465-467. doi: 10.4081/aiua.2021.4.465. Arch Ital Urol Androl. 2021. PMID: 34933532 Free article.
Male infertility is an important factor accounting for 40-50% of infertility cases that may be due to disturbance in one of the parameters as concentration, motility and morphology observed in one or two semen analysis with an interval of 1 and 4 weeks. ...Su …
Male infertility is an important factor accounting for 40-50% of infertility cases that may be due to disturbance in on …
The role of N-acetyl-cysteine (NAC) orally daily on the sperm parameters and serum hormones in idiopathic infertile men: A systematic review and meta-analysis of randomised controlled trials.
Zhou Z, Cui Y, Zhang X, Zhang Y. Zhou Z, et al. Andrologia. 2021 Mar;53(2):e13953. doi: 10.1111/and.13953. Epub 2021 Jan 6. Andrologia. 2021. PMID: 33405232

The results indicated that the NAC group had a considerable improvement in sperm concentration (mean difference [MD], 3.80; p < .00001), ejaculate volume (MD, 0.69; p = .002), sperm motility (MD, 4.69; p < .0001) and normal morphology (MD, 1.68; p = .0002) com

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The results indicated that the NAC group had a considerable improvement in sperm concentration (mean difference [MD], 3.80; p < .0

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Effects of N-Acetylcysteine Supplementation on Oxidative Stress and Expression of Apoptosis-Related Genes in Testicular Tissue of Rats Exposed to Lead.
Abedini Bajgiran F, Khazaei Koohpar Z, Salehzadeh A. Abedini Bajgiran F, et al. Biol Trace Elem Res. 2023 May;201(5):2407-2415. doi: 10.1007/s12011-022-03325-0. Epub 2022 Jun 28. Biol Trace Elem Res. 2023. PMID: 35761113
OBJECTIVES: The current study scrutinized the mitigating effects of N-acetylcysteine (NAC) on lead toxicity, oxidative stress, and apoptotic/anti-apoptotic genes in the testis tissues of male rats. ...NAC treatments not only improved morphological changes and …
OBJECTIVES: The current study scrutinized the mitigating effects of N-acetylcysteine (NAC) on lead toxicity, oxidative stress, …
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