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1988 1
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Page 1
Triflimide-Promoted Nucleophilic C-Arylation of Halopurines to Access N(7)-Substituted Purine Biaryls.
Shoji T, Fukushima K, Menjo T, Yamada Y, Hanasaki T, Kikushima K, Takenaga N, Dohi T. Shoji T, et al. Among authors: hanasaki t. Chem Pharm Bull (Tokyo). 2021 Sep 1;69(9):886-891. doi: 10.1248/cpb.c21-00380. Epub 2021 Jun 18. Chem Pharm Bull (Tokyo). 2021. PMID: 34148910 Free article.
With respect to the C(6)-arylation of halopurines, which possess a substituent at the N(7)-position, only a small number of successful cases have been reported, which is predominately a result of large steric hinderance effects. Herein, we report efficient and metal-free C …
With respect to the C(6)-arylation of halopurines, which possess a substituent at the N(7)-position, only a small number of successfu …
CD22-mediated cell adhesion to cytokine-activated human endothelial cells. Positive and negative regulation by alpha 2-6-sialylation of cellular glycoproteins.
Hanasaki K, Varki A, Powell LD. Hanasaki K, et al. J Biol Chem. 1995 Mar 31;270(13):7533-42. doi: 10.1074/jbc.270.13.7533. J Biol Chem. 1995. PMID: 7706300 Free article.
Tumor necrosis factor-alpha stimulation of HEC causes no change in the profile of endothelial glycoproteins recognized by CD22, but doubles the proportion of total cellular N-linked oligosaccharides capable of binding tightly to CD22. This modest change is sufficient to ca …
Tumor necrosis factor-alpha stimulation of HEC causes no change in the profile of endothelial glycoproteins recognized by CD22, but doubles …
The Tōhoku Theater Project in Postdisaster Japan: An Exemplar for Addressing Community Mental Health in the Context of Disaster.
Pike KM, Rebello TJ, Hanasaki S, Narita-Ohtaki R, Kaufman P, Akiyama T, Doerries B, Yang LH, Suzuki N, Magill EB, Yasumura S. Pike KM, et al. Among authors: hanasaki s. Psychiatr Serv. 2022 Jun;73(6):712-715. doi: 10.1176/appi.ps.202000520. Epub 2021 Oct 20. Psychiatr Serv. 2022. PMID: 34666511
The four performances fostered important discussions regarding the psychological impact of the Tohoku disasters. Participants (N=143) found the theater performance effective at facilitating discussion, increasing empathy, and enhancing mental health knowledge, coping, and …
The four performances fostered important discussions regarding the psychological impact of the Tohoku disasters. Participants (N=143) …
Helicity Control of Circularly Polarized Luminescence from Aromatic Conjugated Copolymers and Their Mixture Using Reversibly Photoinvertible Chiral Liquid Crystals.
Yoshida S, Morikawa S, Ueda K, Kaneko K, Hanasaki T, Akagi K. Yoshida S, et al. Among authors: hanasaki t. ACS Appl Mater Interfaces. 2024 Jan 24;16(3):3991-4002. doi: 10.1021/acsami.3c15512. Epub 2024 Jan 6. ACS Appl Mater Interfaces. 2024. PMID: 38183275
We synthesized cyclic chiral compounds [(R)/(S)-D2s] by linking a photoresponsive bisbenzothienylethene (BTE) moiety with an axially chiral binaphthyl moiety. Chiral nematic liquid crystals (N*-LCs) were prepared by adding chiral compounds as dopants to host N-LCs. …
We synthesized cyclic chiral compounds [(R)/(S)-D2s] by linking a photoresponsive bisbenzothienylethene (BTE) moiety with an axially chiral …
Anti-HIV-1 activity of thiadiazole derivatives: structure-activity relationship, reverse transcriptase inhibition, and lipophilicity.
Ijichi K, Fujiwara M, Nagano H, Matsumoto Y, Hanasaki Y, Ide T, Katsuura K, Takayama H, Shirakawa S, Aimi N, Shigeta S, Konno K, Matsushima M, Yokota T, Baba M. Ijichi K, et al. Among authors: hanasaki y. Antiviral Res. 1996 Jun;31(1-2):87-94. doi: 10.1016/0166-3542(96)00950-3. Antiviral Res. 1996. PMID: 8793012
The structure-activity relationship of the non-nucleoside HIV-1-specific reverse transcriptase (RT) inhibitors 4-phenyl-1,2,5-thiadiazol-3-yl N,N-dialkylcarbamate (TDA) derivatives was investigated with respect to their anti-HIV-1 activity, RT inhibition, and lipoph …
The structure-activity relationship of the non-nucleoside HIV-1-specific reverse transcriptase (RT) inhibitors 4-phenyl-1,2,5-thiadiazol-3-y …
Identification of glycosylated exendin-4 analogue with prolonged blood glucose-lowering activity through glycosylation scanning substitution.
Ueda T, Ito T, Tomita K, Togame H, Fumoto M, Asakura K, Oshima T, Nishimura S, Hanasaki K. Ueda T, et al. Among authors: hanasaki k. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4631-4. doi: 10.1016/j.bmcl.2010.06.002. Epub 2010 Jun 4. Bioorg Med Chem Lett. 2010. PMID: 20576431
In order to further improve in vivo activity, we examined the introduction of sialyl N-acetyllactosamine (sialyl LacNAc) to exendin-4. The glycosylated analogue having sialyl LacNAc at position 28 was found to have improved in vivo activity with prolonged glucose-lowering …
In order to further improve in vivo activity, we examined the introduction of sialyl N-acetyllactosamine (sialyl LacNAc) to exendin-4 …
Purification and characterization of a high-affinity binding protein for pancreatic-type phospholipase A2.
Hanasaki K, Arita H. Hanasaki K, et al. Biochim Biophys Acta. 1992 Aug 19;1127(3):233-41. doi: 10.1016/0005-2760(92)90226-l. Biochim Biophys Acta. 1992. PMID: 1511001
The PLA2-I binding protein in the membranes was solubilized in an active form with n-octyl beta-D-thioglucoside, and then purified approx. 16,000-fold. ...The purified protein possessed a binding capacity with high affinity and specificity for a mammalian mature type of PL …
The PLA2-I binding protein in the membranes was solubilized in an active form with n-octyl beta-D-thioglucoside, and then purified ap …
Cytokine-induced beta-galactoside alpha-2,6-sialyltransferase in human endothelial cells mediates alpha 2,6-sialylation of adhesion molecules and CD22 ligands.
Hanasaki K, Varki A, Stamenkovic I, Bevilacqua MP. Hanasaki K, et al. J Biol Chem. 1994 Apr 8;269(14):10637-43. J Biol Chem. 1994. PMID: 8144653 Free article.
Analysis of labeled HEC showed both a relative and an absolute increase of alpha 2,6-linked sialic acid on N-linked oligosaccharides after TNF-alpha stimulation. This coincided with increased expression of endothelial glycoproteins bearing N-linked glycans with alph …
Analysis of labeled HEC showed both a relative and an absolute increase of alpha 2,6-linked sialic acid on N-linked oligosaccharides …
25 results