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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 1
1946 7
1947 13
1948 19
1949 21
1950 104
1951 77
1952 149
1953 126
1954 172
1955 156
1956 186
1957 185
1958 185
1959 97
1960 56
1961 66
1962 103
1963 538
1964 755
1965 782
1966 740
1967 861
1968 979
1969 1051
1970 1040
1971 1097
1972 1248
1973 1051
1974 977
1975 1105
1976 1007
1977 948
1978 844
1979 836
1980 938
1981 765
1982 882
1983 810
1984 952
1985 896
1986 878
1987 839
1988 802
1989 903
1990 900
1991 890
1992 908
1993 891
1994 916
1995 965
1996 937
1997 1005
1998 982
1999 1055
2000 1006
2001 1103
2002 1125
2003 1143
2004 1204
2005 1315
2006 1207
2007 1302
2008 1394
2009 1406
2010 1440
2011 1526
2012 1644
2013 1829
2014 1804
2015 1792
2016 1812
2017 1818
2018 1881
2019 2004
2020 2152
2021 2263
2022 2147
2023 23
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68,204 results
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Page 1
Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence.
Rajman L, Chwalek K, Sinclair DA. Rajman L, et al. Cell Metab. 2018 Mar 6;27(3):529-547. doi: 10.1016/j.cmet.2018.02.011. Cell Metab. 2018. PMID: 29514064 Free PMC article. Review.
More recently, it has emerged as a signaling molecule. By modulating NAD(+)-sensing enzymes, NAD(+) controls hundreds of key processes from energy metabolism to cell survival, rising and falling depending on food intake, exercise, and the time of day. NAD(+) …
More recently, it has emerged as a signaling molecule. By modulating NAD(+)-sensing enzymes, NAD(+) controls hundreds of key p …
NAD+ homeostasis in human health and disease.
Zapata-Pérez R, Wanders RJA, van Karnebeek CDM, Houtkooper RH. Zapata-Pérez R, et al. EMBO Mol Med. 2021 Jul 7;13(7):e13943. doi: 10.15252/emmm.202113943. Epub 2021 May 27. EMBO Mol Med. 2021. PMID: 34041853 Free PMC article. Review.
Primary deficiencies of NAD(+) homeostasis are the result of impaired biosynthesis, while secondary deficiencies can arise due to other factors affecting NAD(+) homeostasis, such as increased NAD(+) consumption or dietary deficiency of its vitamin B3 precurso …
Primary deficiencies of NAD(+) homeostasis are the result of impaired biosynthesis, while secondary deficiencies can arise due to oth …
NAD+ Metabolism in Cardiac Health, Aging, and Disease.
Abdellatif M, Sedej S, Kroemer G. Abdellatif M, et al. Circulation. 2021 Nov 30;144(22):1795-1817. doi: 10.1161/CIRCULATIONAHA.121.056589. Epub 2021 Nov 29. Circulation. 2021. PMID: 34843394
Pharmacological or genetic inhibition of NAD(+)-degrading enzymes, external supplementation of NAD(+) precursors, and transgenic overexpression of NAD(+)-generating enzymes have wide positive effects on metabolic health and age-associated diseases. ...Here, w …
Pharmacological or genetic inhibition of NAD(+)-degrading enzymes, external supplementation of NAD(+) precursors, and transgen …
NAD+ : A key metabolic regulator with great therapeutic potential.
Sultani G, Samsudeen AF, Osborne B, Turner N. Sultani G, et al. J Neuroendocrinol. 2017 Oct;29(10). doi: 10.1111/jne.12508. J Neuroendocrinol. 2017. PMID: 28718934 Review.
There are a multitude of pathways involved in the synthesis and breakdown of NAD(+) , and alterations in NAD(+) homeostasis have emerged as a common feature of a range of disease states. Here, we provide an overview of NAD(+) metabolism and summarise progress …
There are a multitude of pathways involved in the synthesis and breakdown of NAD(+) , and alterations in NAD(+) homeostasis ha …
Interacting NAD+ and Cell Senescence Pathways Complicate Antiaging Therapies.
Mendelsohn AR, Larrick JW. Mendelsohn AR, et al. Rejuvenation Res. 2019 Jun;22(3):261-266. doi: 10.1089/rej.2019.2218. Rejuvenation Res. 2019. PMID: 31140365 Review.
In turn, increased CD38 expression is believed to be the key modulator of lowered NAD(+) levels with aging in mammals. So, accumulation of senescent cells may itself be a root cause of decreased NAD(+), which in turn could promote dysfunction. ...The elimination of …
In turn, increased CD38 expression is believed to be the key modulator of lowered NAD(+) levels with aging in mammals. So, accumulati …
Advances in NAD-Lowering Agents for Cancer Treatment.
Ghanem MS, Monacelli F, Nencioni A. Ghanem MS, et al. Nutrients. 2021 May 14;13(5):1665. doi: 10.3390/nu13051665. Nutrients. 2021. PMID: 34068917 Free PMC article. Review.
Nicotinamide adenine dinucleotide (NAD) is an essential redox cofactor, but it also acts as a substrate for NAD-consuming enzymes, regulating cellular events such as DNA repair and gene expression. ...NAD can be generated from tryptophan or nicotinic acid. In …
Nicotinamide adenine dinucleotide (NAD) is an essential redox cofactor, but it also acts as a substrate for NAD-consuming enzy …
Host NAD+ metabolism and infections: therapeutic implications.
Singhal A, Cheng CY. Singhal A, et al. Int Immunol. 2019 Feb 15;31(2):59-67. doi: 10.1093/intimm/dxy068. Int Immunol. 2019. PMID: 30329059 Review.
Recent studies delineate impaired host NAD+ metabolism during chronic infections and inflammation, suggesting NAD+ replenishment as an avenue to ameliorate deleterious inflammatory responses. Here, we discuss aspects of NAD+ biosynthesis and consumption, N
Recent studies delineate impaired host NAD+ metabolism during chronic infections and inflammation, suggesting NAD+ replenishme …
Metabolic control by sirtuins and other enzymes that sense NAD+, NADH, or their ratio.
Anderson KA, Madsen AS, Olsen CA, Hirschey MD. Anderson KA, et al. Biochim Biophys Acta Bioenerg. 2017 Dec;1858(12):991-998. doi: 10.1016/j.bbabio.2017.09.005. Epub 2017 Sep 22. Biochim Biophys Acta Bioenerg. 2017. PMID: 28947253 Free PMC article. Review.
In its reduced form, NADH is a ubiquitous cellular electron donor. NAD(+), NADH, and the NAD(+)/NADH ratio have long been known to control the activity of several oxidoreductase enzymes. More recently, enzymes outside those participating directly in redox control ha …
In its reduced form, NADH is a ubiquitous cellular electron donor. NAD(+), NADH, and the NAD(+)/NADH ratio have long been know …
Implications of NAD metabolism in pathophysiology and therapeutics for neurodegenerative diseases.
Hikosaka K, Yaku K, Okabe K, Nakagawa T. Hikosaka K, et al. Nutr Neurosci. 2021 May;24(5):371-383. doi: 10.1080/1028415X.2019.1637504. Epub 2019 Jul 7. Nutr Neurosci. 2021. PMID: 31280708 Review.
Nicotinamide adenine dinucleotide (NAD) is an essential coenzyme that mediates various redox reactions. ...In this review, we summarize the involvement of NAD metabolism in axon degeneration and various neurodegenerative diseases and discuss perspectives of nutritio …
Nicotinamide adenine dinucleotide (NAD) is an essential coenzyme that mediates various redox reactions. ...In this review, we summari …
Therapeutic potential of nicotinamide adenine dinucleotide (NAD).
Arenas-Jal M, Suñé-Negre JM, García-Montoya E. Arenas-Jal M, et al. Eur J Pharmacol. 2020 Jul 15;879:173158. doi: 10.1016/j.ejphar.2020.173158. Epub 2020 Apr 28. Eur J Pharmacol. 2020. PMID: 32360833 Review.
While alterations in NAD homeostasis are a common feature of different conditions and age-associated diseases, in general, increased NAD levels have been associated with beneficial health effects. ...In fact, different approaches to replenish or increase NAD
While alterations in NAD homeostasis are a common feature of different conditions and age-associated diseases, in general, increased …
68,204 results
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