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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 1
1946 7
1947 13
1948 19
1949 21
1950 104
1951 77
1952 149
1953 126
1954 172
1955 156
1956 186
1957 185
1958 185
1959 97
1960 56
1961 66
1962 103
1963 538
1964 755
1965 782
1966 740
1967 861
1968 979
1969 1051
1970 1040
1971 1097
1972 1248
1973 1051
1974 977
1975 1104
1976 1007
1977 948
1978 844
1979 836
1980 938
1981 765
1982 882
1983 810
1984 952
1985 896
1986 878
1987 839
1988 802
1989 903
1990 900
1991 890
1992 908
1993 891
1994 916
1995 965
1996 937
1997 1005
1998 981
1999 1055
2000 1006
2001 1102
2002 1125
2003 1142
2004 1203
2005 1315
2006 1207
2007 1302
2008 1394
2009 1405
2010 1439
2011 1524
2012 1643
2013 1829
2014 1799
2015 1787
2016 1804
2017 1813
2018 1866
2019 1967
2020 1969
2021 149
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64,099 results
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Page 1
Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence.
Rajman L, Chwalek K, Sinclair DA. Rajman L, et al. Cell Metab. 2018 Mar 6;27(3):529-547. doi: 10.1016/j.cmet.2018.02.011. Cell Metab. 2018. PMID: 29514064 Free PMC article. Review.
More recently, it has emerged as a signaling molecule. By modulating NAD(+)-sensing enzymes, NAD(+) controls hundreds of key processes from energy metabolism to cell survival, rising and falling depending on food intake, exercise, and the time of day. NAD(+) …
More recently, it has emerged as a signaling molecule. By modulating NAD(+)-sensing enzymes, NAD(+) controls hundreds of key p …
NAD(+) : A key metabolic regulator with great therapeutic potential.
Sultani G, Samsudeen AF, Osborne B, Turner N. Sultani G, et al. J Neuroendocrinol. 2017 Oct;29(10). doi: 10.1111/jne.12508. J Neuroendocrinol. 2017. PMID: 28718934 Review.
There are a multitude of pathways involved in the synthesis and breakdown of NAD(+) , and alterations in NAD(+) homeostasis have emerged as a common feature of a range of disease states. Here, we provide an overview of NAD(+) metabolism and summarise progress …
There are a multitude of pathways involved in the synthesis and breakdown of NAD(+) , and alterations in NAD(+) homeostasis ha …
Interacting NAD(+) and Cell Senescence Pathways Complicate Antiaging Therapies.
Mendelsohn AR, Larrick JW. Mendelsohn AR, et al. Rejuvenation Res. 2019 Jun;22(3):261-266. doi: 10.1089/rej.2019.2218. Rejuvenation Res. 2019. PMID: 31140365 Review.
In turn, increased CD38 expression is believed to be the key modulator of lowered NAD(+) levels with aging in mammals. So, accumulation of senescent cells may itself be a root cause of decreased NAD(+), which in turn could promote dysfunction. ...The elimination of …
In turn, increased CD38 expression is believed to be the key modulator of lowered NAD(+) levels with aging in mammals. So, accumulati …
Host NAD+ metabolism and infections: therapeutic implications.
Singhal A, Cheng CY. Singhal A, et al. Int Immunol. 2019 Feb 15;31(2):59-67. doi: 10.1093/intimm/dxy068. Int Immunol. 2019. PMID: 30329059 Review.
Recent studies delineate impaired host NAD+ metabolism during chronic infections and inflammation, suggesting NAD+ replenishment as an avenue to ameliorate deleterious inflammatory responses. Here, we discuss aspects of NAD+ biosynthesis and consumption, N
Recent studies delineate impaired host NAD+ metabolism during chronic infections and inflammation, suggesting NAD+ replenishme …
Emerging potential benefits of modulating NAD(+) metabolism in cardiovascular disease.
Matasic DS, Brenner C, London B. Matasic DS, et al. Am J Physiol Heart Circ Physiol. 2018 Apr 1;314(4):H839-H852. doi: 10.1152/ajpheart.00409.2017. Epub 2017 Dec 22. Am J Physiol Heart Circ Physiol. 2018. PMID: 29351465 Free PMC article. Review.
Therefore, supplementation of NAD(+) precursors, including nicotinamide riboside that boosts or repletes the NAD(+) metabolome, may be cardioprotective. ...In addition, alternative NAD(+)-boosting strategies and potential systemic effects of NAD(+) sup …
Therefore, supplementation of NAD(+) precursors, including nicotinamide riboside that boosts or repletes the NAD(+) metabolome …
The Regulatory Role of NAD in Human and Animal Cells.
Kulikova VA, Gromyko DV, Nikiforov AA. Kulikova VA, et al. Biochemistry (Mosc). 2018 Jul;83(7):800-812. doi: 10.1134/S0006297918070040. Biochemistry (Mosc). 2018. PMID: 30200865 Review.
NAD+ is also a precursor for calcium-mobilizing secondary messengers. Proper regulation of these NAD-dependent metabolic and signaling pathways depends on how efficiently cells can maintain their NAD levels. ...
NAD+ is also a precursor for calcium-mobilizing secondary messengers. Proper regulation of these NAD-dependent metabolic and s
Metabolic control by sirtuins and other enzymes that sense NAD(+), NADH, or their ratio.
Anderson KA, Madsen AS, Olsen CA, Hirschey MD. Anderson KA, et al. Biochim Biophys Acta Bioenerg. 2017 Dec;1858(12):991-998. doi: 10.1016/j.bbabio.2017.09.005. Epub 2017 Sep 22. Biochim Biophys Acta Bioenerg. 2017. PMID: 28947253 Free PMC article. Review.
In its reduced form, NADH is a ubiquitous cellular electron donor. NAD(+), NADH, and the NAD(+)/NADH ratio have long been known to control the activity of several oxidoreductase enzymes. More recently, enzymes outside those participating directly in redox control ha …
In its reduced form, NADH is a ubiquitous cellular electron donor. NAD(+), NADH, and the NAD(+)/NADH ratio have long been know …
Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD(+) in healthy middle-aged and older adults.
Martens CR, Denman BA, Mazzo MR, Armstrong ML, Reisdorph N, McQueen MB, Chonchol M, Seals DR. Martens CR, et al. Nat Commun. 2018 Mar 29;9(1):1286. doi: 10.1038/s41467-018-03421-7. Nat Commun. 2018. PMID: 29599478 Free PMC article. Clinical Trial.
As such, the use of NAD(+) precursors to augment NAD(+) bioavailability has been proposed as a strategy for improving cardiovascular and other physiological functions with aging in humans. Here we provide the evidence in a 2 6-week randomized, double-blind, placebo- …
As such, the use of NAD(+) precursors to augment NAD(+) bioavailability has been proposed as a strategy for improving cardiova …
The NAD metabolome--a key determinant of cancer cell biology.
Chiarugi A, Dölle C, Felici R, Ziegler M. Chiarugi A, et al. Nat Rev Cancer. 2012 Nov;12(11):741-52. doi: 10.1038/nrc3340. Epub 2012 Sep 28. Nat Rev Cancer. 2012. PMID: 23018234 Review.
NAD is a vital molecule in all organisms. It is a key component of both energy and signal transduction--processes that undergo crucial changes in cancer cells. ...This necessity supports the targeting of NAD metabolism as a new therapeutic concept for cancer treatme
NAD is a vital molecule in all organisms. It is a key component of both energy and signal transduction--processes that undergo crucia
NAD Analogs in Aid of Chemical Biology and Medicinal Chemistry.
Depaix A, Kowalska J. Depaix A, et al. Molecules. 2019 Nov 19;24(22):4187. doi: 10.3390/molecules24224187. Molecules. 2019. PMID: 31752261 Free PMC article. Review.
Synthetic NAD analogs are invaluable molecular tools to detect, monitor, structurally investigate, and modulate activity of NAD-related enzymes and biological processes in order to aid their deeper understanding. Here, we review the recent advances in the design and …
Synthetic NAD analogs are invaluable molecular tools to detect, monitor, structurally investigate, and modulate activity of NAD
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