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76,854 results

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Page 1
NAD(+) metabolism and its roles in cellular processes during ageing.
Covarrubias AJ, Perrone R, Grozio A, Verdin E. Covarrubias AJ, et al. Nat Rev Mol Cell Biol. 2021 Feb;22(2):119-141. doi: 10.1038/s41580-020-00313-x. Epub 2020 Dec 22. Nat Rev Mol Cell Biol. 2021. PMID: 33353981 Free PMC article. Review.
Nicotinamide adenine dinucleotide (NAD(+)) is a coenzyme for redox reactions, making it central to energy metabolism. NAD(+) is also an essential cofactor for non-redox NAD(+)-dependent enzymes, including sirtuins, CD38 and poly(ADP-ribose) polymerases. ...Ho …
Nicotinamide adenine dinucleotide (NAD(+)) is a coenzyme for redox reactions, making it central to energy metabolism. NAD(+) i …
NAD(+) metabolism, stemness, the immune response, and cancer.
Navas LE, Carnero A. Navas LE, et al. Signal Transduct Target Ther. 2021 Jan 1;6(1):2. doi: 10.1038/s41392-020-00354-w. Signal Transduct Target Ther. 2021. PMID: 33384409 Free PMC article. Review.
Finally, different NAD hydrolase proteins also consume NAD(+) while converting it into ADP-ribose or its cyclic counterpart. Some of these proteins, such as CD38, seem to be extensively involved in the immune response. Since NAD cannot be taken directly from …
Finally, different NAD hydrolase proteins also consume NAD(+) while converting it into ADP-ribose or its cyclic counterpart. S …
NAD(+) homeostasis in health and disease.
Katsyuba E, Romani M, Hofer D, Auwerx J. Katsyuba E, et al. Nat Metab. 2020 Jan;2(1):9-31. doi: 10.1038/s42255-019-0161-5. Epub 2020 Jan 20. Nat Metab. 2020. PMID: 32694684 Review.
NAD(+) levels decline during ageing, and alterations in NAD(+) homeostasis can be found in virtually all age-related diseases, including neurodegeneration, diabetes and cancer. ...Here, we review the basics of NAD(+) biochemistry and metabolism, and its roles …
NAD(+) levels decline during ageing, and alterations in NAD(+) homeostasis can be found in virtually all age-related diseases, …
Regulation of and challenges in targeting NAD(+) metabolism.
Migaud ME, Ziegler M, Baur JA. Migaud ME, et al. Nat Rev Mol Cell Biol. 2024 Oct;25(10):822-840. doi: 10.1038/s41580-024-00752-w. Epub 2024 Jul 18. Nat Rev Mol Cell Biol. 2024. PMID: 39026037 Free PMC article. Review.
However, much about the biology of NAD(+) and related molecules remains poorly understood. In this Review, we discuss the current knowledge of NAD(+) metabolism, including limitations of, assumptions about and unappreciated factors that might influence the success o …
However, much about the biology of NAD(+) and related molecules remains poorly understood. In this Review, we discuss the current kno …
NAD(+) homeostasis in human health and disease.
Zapata-Pérez R, Wanders RJA, van Karnebeek CDM, Houtkooper RH. Zapata-Pérez R, et al. EMBO Mol Med. 2021 Jul 7;13(7):e13943. doi: 10.15252/emmm.202113943. Epub 2021 May 27. EMBO Mol Med. 2021. PMID: 34041853 Free PMC article. Review.
Primary deficiencies of NAD(+) homeostasis are the result of impaired biosynthesis, while secondary deficiencies can arise due to other factors affecting NAD(+) homeostasis, such as increased NAD(+) consumption or dietary deficiency of its vitamin B3 precurso …
Primary deficiencies of NAD(+) homeostasis are the result of impaired biosynthesis, while secondary deficiencies can arise due to oth …
Evolving concepts in NAD(+) metabolism.
Chini CCS, Zeidler JD, Kashyap S, Warner G, Chini EN. Chini CCS, et al. Cell Metab. 2021 Jun 1;33(6):1076-1087. doi: 10.1016/j.cmet.2021.04.003. Epub 2021 Apr 29. Cell Metab. 2021. PMID: 33930322 Free PMC article. Review.
However, NAD pathway metabolites have many other important functions, including roles in signaling pathways, post-translational modifications, epigenetic changes, and regulation of RNA stability and function via NAD-capping of RNA. ...In this perspective, we discuss …
However, NAD pathway metabolites have many other important functions, including roles in signaling pathways, post-translational modif …
Role of NAD(+) in regulating cellular and metabolic signaling pathways.
Amjad S, Nisar S, Bhat AA, Shah AR, Frenneaux MP, Fakhro K, Haris M, Reddy R, Patay Z, Baur J, Bagga P. Amjad S, et al. Mol Metab. 2021 Jul;49:101195. doi: 10.1016/j.molmet.2021.101195. Epub 2021 Feb 17. Mol Metab. 2021. PMID: 33609766 Free PMC article. Review.
Increasing evidence has shown the efficacy of boosting NAD(+) levels using NAD(+) precursors in various diseases. This review provides a comprehensive understanding into the role of NAD(+) in aging and other pathologies and discusses potential therapeutic tar …
Increasing evidence has shown the efficacy of boosting NAD(+) levels using NAD(+) precursors in various diseases. This review …
Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence.
Rajman L, Chwalek K, Sinclair DA. Rajman L, et al. Cell Metab. 2018 Mar 6;27(3):529-547. doi: 10.1016/j.cmet.2018.02.011. Cell Metab. 2018. PMID: 29514064 Free PMC article. Review.
More recently, it has emerged as a signaling molecule. By modulating NAD(+)-sensing enzymes, NAD(+) controls hundreds of key processes from energy metabolism to cell survival, rising and falling depending on food intake, exercise, and the time of day. NAD(+) …
More recently, it has emerged as a signaling molecule. By modulating NAD(+)-sensing enzymes, NAD(+) controls hundreds of key p …
NAD(+) precursor supplementation in human ageing: clinical evidence and challenges.
Vinten KT, Trętowicz MM, Coskun E, van Weeghel M, Cantó C, Zapata-Pérez R, Janssens GE, Houtkooper RH. Vinten KT, et al. Nat Metab. 2025 Oct;7(10):1974-1990. doi: 10.1038/s42255-025-01387-7. Epub 2025 Oct 13. Nat Metab. 2025. PMID: 41083806 Review.
Therefore, an increasing understanding of how NAD(+) metabolism is affected in different tissues during disease and following NAD(+) precursor supplementation is crucial to defining the therapeutic value of NAD(+)-targeted therapies. In this Review, we evalua …
Therefore, an increasing understanding of how NAD(+) metabolism is affected in different tissues during disease and following NAD …
NAD(+) Metabolism in Cardiac Health, Aging, and Disease.
Abdellatif M, Sedej S, Kroemer G. Abdellatif M, et al. Circulation. 2021 Nov 30;144(22):1795-1817. doi: 10.1161/CIRCULATIONAHA.121.056589. Epub 2021 Nov 29. Circulation. 2021. PMID: 34843394
Pharmacological or genetic inhibition of NAD(+)-degrading enzymes, external supplementation of NAD(+) precursors, and transgenic overexpression of NAD(+)-generating enzymes have wide positive effects on metabolic health and age-associated diseases. ...Here, w …
Pharmacological or genetic inhibition of NAD(+)-degrading enzymes, external supplementation of NAD(+) precursors, and transgen …
76,854 results
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