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Year Number of Results
2000 8
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1,456 results

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Page 1
NAD+ and sirtuins in aging and disease.
Imai S, Guarente L. Imai S, et al. Trends Cell Biol. 2014 Aug;24(8):464-71. doi: 10.1016/j.tcb.2014.04.002. Epub 2014 Apr 29. Trends Cell Biol. 2014. PMID: 24786309 Free PMC article. Review.
Nicotinamide adenine dinucleotide (NAD(+)) is a classical coenzyme mediating many redox reactions. NAD(+) also plays an important role in the regulation of NAD(+)-consuming enzymes, including sirtuins, poly-ADP-ribose polymerases (PARPs), and CD38/157 …
Nicotinamide adenine dinucleotide (NAD(+)) is a classical coenzyme mediating many redox reactions. NAD(+) also plays an import …
NAD+ in aging, metabolism, and neurodegeneration.
Verdin E. Verdin E. Science. 2015 Dec 4;350(6265):1208-13. doi: 10.1126/science.aac4854. Science. 2015. PMID: 26785480 Review.
Cellular NAD(+) concentrations change during aging, and modulation of NAD(+) usage or production can prolong both health span and life span. Here we review factors that regulate NAD(+) and discuss how supplementation with NAD(+) precursors may r …
Cellular NAD(+) concentrations change during aging, and modulation of NAD(+) usage or production can prolong both healt …
NAD(+) Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging.
Levine DC, Hong H, Weidemann BJ, Ramsey KM, Affinati AH, Schmidt MS, Cedernaes J, Omura C, Braun R, Lee C, Brenner C, Peek CB, Bass J. Levine DC, et al. Mol Cell. 2020 Jun 4;78(5):835-849.e7. doi: 10.1016/j.molcel.2020.04.010. Epub 2020 May 4. Mol Cell. 2020. PMID: 32369735 Free PMC article.
Disrupted sleep-wake and molecular circadian rhythms are a feature of aging associated with metabolic disease and reduced levels of NAD(+), yet whether changes in nucleotide metabolism control circadian behavioral and genomic rhythms remains unknown. Here, we reveal …
Disrupted sleep-wake and molecular circadian rhythms are a feature of aging associated with metabolic disease and reduced levels of …
The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling.
Mouchiroud L, Houtkooper RH, Moullan N, Katsyuba E, Ryu D, Cantó C, Mottis A, Jo YS, Viswanathan M, Schoonjans K, Guarente L, Auwerx J. Mouchiroud L, et al. Cell. 2013 Jul 18;154(2):430-41. doi: 10.1016/j.cell.2013.06.016. Cell. 2013. PMID: 23870130 Free PMC article.
NAD(+) is an important cofactor regulating metabolic homeostasis and a rate-limiting substrate for sirtuin deacylases. We show that NAD(+) levels are reduced in aged mice and Caenorhabditis elegans and that decreasing NAD(+) levels results in a further …
NAD(+) is an important cofactor regulating metabolic homeostasis and a rate-limiting substrate for sirtuin deacylases. We show …
NAD(+) homeostasis in health and disease.
Katsyuba E, Romani M, Hofer D, Auwerx J. Katsyuba E, et al. Nat Metab. 2020 Jan;2(1):9-31. doi: 10.1038/s42255-019-0161-5. Epub 2020 Jan 20. Nat Metab. 2020. PMID: 32694684 Review.
The conceptual evolution of nicotinamide adenine dinucleotide (NAD(+)) from being seen as a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and longevity, including the sirtuin family of protein deacylases, has led to a new wave …
The conceptual evolution of nicotinamide adenine dinucleotide (NAD(+)) from being seen as a simple metabolic cofactor to a pivotal co …
Impairment of an Endothelial NAD(+)-H(2)S Signaling Network Is a Reversible Cause of Vascular Aging.
Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA. Das A, et al. Cell. 2018 Mar 22;173(1):74-89.e20. doi: 10.1016/j.cell.2018.02.008. Cell. 2018. PMID: 29570999 Free PMC article.
Understanding why this occurs is key to future gains in human health. NAD precursors reverse aspects of aging, in part, by activating sirtuin deacylases (SIRT1-SIRT7) that mediate the benefits of exercise and dietary restriction (DR). We show that SIRT1 in en …
Understanding why this occurs is key to future gains in human health. NAD precursors reverse aspects of aging, in part, by act …
Calorie restriction and NAD+/sirtuin counteract the hallmarks of aging.
Michan S. Michan S. Front Biosci (Landmark Ed). 2014 Jun 1;19(8):1300-19. doi: 10.2741/4283. Front Biosci (Landmark Ed). 2014. PMID: 24896352 Free article. Review.
Currently, the NAD + /sirtuin pathway is one of the few mechanisms described to mediate CR effects and sirtuin-activating compounds (STACs) mimic many effects of CR. Herein, we discuss the effects of CR on healthspan with emphasis on neuroprotection, how CR c …
Currently, the NAD + /sirtuin pathway is one of the few mechanisms described to mediate CR effects and sirtuin-activati …
Role of NAD(+) in regulating cellular and metabolic signaling pathways.
Amjad S, Nisar S, Bhat AA, Shah AR, Frenneaux MP, Fakhro K, Haris M, Reddy R, Patay Z, Baur J, Bagga P. Amjad S, et al. Mol Metab. 2021 Jul;49:101195. doi: 10.1016/j.molmet.2021.101195. Epub 2021 Feb 17. Mol Metab. 2021. PMID: 33609766 Free PMC article. Review.
For this reason, NAD(+) is often studied in the context of aging, cancer, and neurodegenerative and metabolic disorders. ...Increasing evidence has shown the efficacy of boosting NAD(+) levels using NAD(+) precursors in various diseases. This review pr …
For this reason, NAD(+) is often studied in the context of aging, cancer, and neurodegenerative and metabolic disorders. ...In …
CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism.
Camacho-Pereira J, Tarragó MG, Chini CCS, Nin V, Escande C, Warner GM, Puranik AS, Schoon RA, Reid JM, Galina A, Chini EN. Camacho-Pereira J, et al. Cell Metab. 2016 Jun 14;23(6):1127-1139. doi: 10.1016/j.cmet.2016.05.006. Cell Metab. 2016. PMID: 27304511 Free PMC article.
Nicotinamide adenine dinucleotide (NAD) levels decrease during aging and are involved in age-related metabolic decline. ...We also identified CD38 as the main enzyme involved in the degradation of the NAD precursor nicotinamide mononucleotide (NMN) in vivo, i …
Nicotinamide adenine dinucleotide (NAD) levels decrease during aging and are involved in age-related metabolic decline. ...We …
Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.
Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA. Gomes AP, et al. Cell. 2013 Dec 19;155(7):1624-38. doi: 10.1016/j.cell.2013.11.037. Cell. 2013. PMID: 24360282 Free PMC article.
Mitochondrial dysfunction is a hallmark of aging, but its causes are debated. We show that, during aging, there is a specific loss of mitochondrial, but not nuclear, encoded OXPHOS subunits. ...Deleting SIRT1 accelerates this process, whereas raising NAD(+) l …
Mitochondrial dysfunction is a hallmark of aging, but its causes are debated. We show that, during aging, there is a specific …
1,456 results