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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1953 1
1957 2
1958 2
1960 1
1963 1
1964 3
1966 1
1967 3
1968 3
1969 1
1970 1
1971 5
1972 1
1973 3
1975 6
1976 4
1977 8
1978 4
1979 7
1980 6
1981 5
1982 12
1983 11
1984 11
1985 14
1986 4
1987 11
1988 8
1989 15
1990 8
1991 6
1992 5
1993 15
1994 16
1995 11
1996 8
1997 13
1998 14
1999 19
2000 14
2001 13
2002 6
2003 9
2004 15
2005 13
2006 11
2007 17
2008 14
2009 16
2010 25
2011 22
2012 30
2013 44
2014 41
2015 41
2016 40
2017 57
2018 49
2019 51
2020 74
2021 76
2022 96
2023 91
2024 87
2025 97
2026 52

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1,253 results

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Page 1
NAD+ and sirtuins in aging and disease.
Imai S, Guarente L. Imai S, et al. Trends Cell Biol. 2014 Aug;24(8):464-71. doi: 10.1016/j.tcb.2014.04.002. Epub 2014 Apr 29. Trends Cell Biol. 2014. PMID: 24786309 Free PMC article. Review.
Nicotinamide adenine dinucleotide (NAD(+)) is a classical coenzyme mediating many redox reactions. NAD(+) also plays an important role in the regulation of NAD(+)-consuming enzymes, including sirtuins, poly-ADP-ribose polymerases (PARPs), and CD38/157 ectoenz …
Nicotinamide adenine dinucleotide (NAD(+)) is a classical coenzyme mediating many redox reactions. NAD(+) also plays an import …
NAD(+) Intermediates: The Biology and Therapeutic Potential of NMN and NR.
Yoshino J, Baur JA, Imai SI. Yoshino J, et al. Cell Metab. 2018 Mar 6;27(3):513-528. doi: 10.1016/j.cmet.2017.11.002. Epub 2017 Dec 14. Cell Metab. 2018. PMID: 29249689 Free PMC article. Review.
Supplementing these NAD(+) intermediates has shown preventive and therapeutic effects, ameliorating age-associated pathophysiologies and disease conditions. Although the pharmacokinetics and metabolic fates of NMN and NR are still under intensive investigation, thes …
Supplementing these NAD(+) intermediates has shown preventive and therapeutic effects, ameliorating age-associated pathophysio …
Evaluation of safety and effectiveness of NAD in different clinical conditions: a systematic review.
Gindri IM, Ferrari G, Pinto LPS, Bicca J, Dos Santos IK, Dallacosta D, Roesler CRM. Gindri IM, et al. Am J Physiol Endocrinol Metab. 2024 Apr 1;326(4):E417-E427. doi: 10.1152/ajpendo.00242.2023. Epub 2023 Nov 16. Am J Physiol Endocrinol Metab. 2024. PMID: 37971292 Free article.
Nicotinamide adenine dinucleotide (NAD(+)) is an essential pyridine nucleotide cofactor that is present in cells and in several important biological processes, including oxidative phosphorylation and production of adenosine triphosphate, DNA repair, calcium-dependent secon …
Nicotinamide adenine dinucleotide (NAD(+)) is an essential pyridine nucleotide cofactor that is present in cells and in several impor …
The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update.
Song Q, Zhou X, Xu K, Liu S, Zhu X, Yang J. Song Q, et al. Adv Nutr. 2023 Nov;14(6):1416-1435. doi: 10.1016/j.advnut.2023.08.008. Epub 2023 Aug 22. Adv Nutr. 2023. PMID: 37619764 Free PMC article. Review.
The importance of nicotinamide adenine dinucleotide (NAD(+)) in human physiology is well recognized. As the NAD(+) concentration in human skin, blood, liver, muscle, and brain are thought to decrease with age, finding ways to increase NAD(+) status could poss …
The importance of nicotinamide adenine dinucleotide (NAD(+)) in human physiology is well recognized. As the NAD(+) concentrati …
Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions.
Freeberg KA, Udovich CC, Martens CR, Seals DR, Craighead DH. Freeberg KA, et al. J Gerontol A Biol Sci Med Sci. 2023 Dec 1;78(12):2435-2448. doi: 10.1093/gerona/glad106. J Gerontol A Biol Sci Med Sci. 2023. PMID: 37068054 Free PMC article. Review.
Advancing age and many disease states are associated with declines in nicotinamide adenine dinucleotide (NAD+) levels. Preclinical studies suggest that boosting NAD+ abundance with precursor compounds, such as nicotinamide riboside or nicotinamide mononucleotide, ha …
Advancing age and many disease states are associated with declines in nicotinamide adenine dinucleotide (NAD+) levels. Preclinical st …
NAD(+) supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING.
Hou Y, Wei Y, Lautrup S, Yang B, Wang Y, Cordonnier S, Mattson MP, Croteau DL, Bohr VA. Hou Y, et al. Proc Natl Acad Sci U S A. 2021 Sep 14;118(37):e2011226118. doi: 10.1073/pnas.2011226118. Proc Natl Acad Sci U S A. 2021. PMID: 34497121 Free PMC article.
Here, we report that levels of NAD(+) are reduced and markers of inflammation increased in the brains of APP/PS1 mutant transgenic mice with beta-amyloid pathology. Treatment of APP/PS1 mutant mice with the NAD(+) precursor nicotinamide riboside (NR) for 5 mo increa …
Here, we report that levels of NAD(+) are reduced and markers of inflammation increased in the brains of APP/PS1 mutant transgenic mi …
NAD(+) precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury.
Doke T, Mukherjee S, Mukhi D, Dhillon P, Abedini A, Davis JG, Chellappa K, Chen B, Baur JA, Susztak K. Doke T, et al. Nat Metab. 2023 Mar;5(3):414-430. doi: 10.1038/s42255-023-00761-7. Epub 2023 Mar 13. Nat Metab. 2023. PMID: 36914909 Free PMC article.
Here we show that nicotinamide adenine dinucleotide (NAD(+)) deficiency drives mitochondrial dysfunction causing inflammation and kidney disease development. Using unbiased global metabolomics in healthy and diseased human kidneys, we identify NAD(+) deficiency as a …
Here we show that nicotinamide adenine dinucleotide (NAD(+)) deficiency drives mitochondrial dysfunction causing inflammation and kid …
The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial.
Yi L, Maier AB, Tao R, Lin Z, Vaidya A, Pendse S, Thasma S, Andhalkar N, Avhad G, Kumbhar V. Yi L, et al. Geroscience. 2023 Feb;45(1):29-43. doi: 10.1007/s11357-022-00705-1. Epub 2022 Dec 8. Geroscience. 2023. PMID: 36482258 Free PMC article. Clinical Trial.
Blood NAD concentrations were highest in the groups taking 600 mg and 900 mg NMN. No safety issues, based on monitoring adverse events (AEs), laboratory and clinical measures, were found, and NMN supplementation was well tolerated. ...Clinical efficacy expressed by blood …
Blood NAD concentrations were highest in the groups taking 600 mg and 900 mg NMN. No safety issues, based on monitoring adverse event …
NAD(+) precursor supplementation in human ageing: clinical evidence and challenges.
Vinten KT, Trętowicz MM, Coskun E, van Weeghel M, Cantó C, Zapata-Pérez R, Janssens GE, Houtkooper RH. Vinten KT, et al. Nat Metab. 2025 Oct;7(10):1974-1990. doi: 10.1038/s42255-025-01387-7. Epub 2025 Oct 13. Nat Metab. 2025. PMID: 41083806 Review.
Therefore, an increasing understanding of how NAD(+) metabolism is affected in different tissues during disease and following NAD(+) precursor supplementation is crucial to defining the therapeutic value of NAD(+)-targeted therapies. In this Review, we evalua …
Therefore, an increasing understanding of how NAD(+) metabolism is affected in different tissues during disease and following NAD …
Nicotinic acid riboside maintains NAD(+) homeostasis and ameliorates aging-associated NAD(+) decline.
Song WS, Shen X, Du K, Ramirez CB, Park SH, Cao Y, Le J, Bae H, Kim J, Chun Y, Khong NJ, Kim M, Jung S, Choi W, Lopez ML, Said Z, Song Z, Lee SG, Nicholas D, Sasaki Y, Milbrandt J, Imagawa DK, Skowronska-Krawczyk D, Chen D, Lee G, Jang C, Yang Q. Song WS, et al. Cell Metab. 2025 Jul 1;37(7):1499-1514.e4. doi: 10.1016/j.cmet.2025.04.007. Epub 2025 May 1. Cell Metab. 2025. PMID: 40315855 Free PMC article.
Liver-derived circulating nicotinamide from nicotinamide adenine dinucleotide (NAD(+)) catabolism primarily feeds systemic organs for NAD(+) synthesis. We surprisingly found that, despite blunted hepatic NAD(+) and nicotinamide production in liver-specific ni …
Liver-derived circulating nicotinamide from nicotinamide adenine dinucleotide (NAD(+)) catabolism primarily feeds systemic organs for …
1,253 results