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Page 1
Did you mean ncd and ageing (471 results)?
NAD+ and sirtuins in aging and disease.
Imai S, Guarente L. Imai S, et al. Trends Cell Biol. 2014 Aug;24(8):464-71. doi: 10.1016/j.tcb.2014.04.002. Epub 2014 Apr 29. Trends Cell Biol. 2014. PMID: 24786309 Free PMC article. Review.
Restoring NAD(+) by supplementing NAD(+) intermediates can dramatically ameliorate these age-associated functional defects, counteracting many diseases of aging, including neurodegenerative diseases. Thus, the combination of sirtuin activation and NAD( …
Restoring NAD(+) by supplementing NAD(+) intermediates can dramatically ameliorate these age-associated functional defects, co …
NAD+ in aging, metabolism, and neurodegeneration.
Verdin E. Verdin E. Science. 2015 Dec 4;350(6265):1208-13. doi: 10.1126/science.aac4854. Science. 2015. PMID: 26785480 Review.
Cellular NAD(+) concentrations change during aging, and modulation of NAD(+) usage or production can prolong both health span and life span. Here we review factors that regulate NAD(+) and discuss how supplementation with NAD(+) precursors may r …
Cellular NAD(+) concentrations change during aging, and modulation of NAD(+) usage or production can prolong both healt …
NAD metabolism: Role in senescence regulation and aging.
Chini CCS, Cordeiro HS, Tran NLK, Chini EN. Chini CCS, et al. Aging Cell. 2024 Jan;23(1):e13920. doi: 10.1111/acel.13920. Epub 2023 Jul 9. Aging Cell. 2024. PMID: 37424179 Free PMC article. Review.
Understanding the interplay between key aspects of the biological hallmarks of aging is essential in delivering the promises of the geroscience hypothesis. Notably, the nucleotide nicotinamide adenine dinucleotide (NAD) interfaces with several biological hallmarks o …
Understanding the interplay between key aspects of the biological hallmarks of aging is essential in delivering the promises of the g …
NAD(+) in Brain Aging and Neurodegenerative Disorders.
Lautrup S, Sinclair DA, Mattson MP, Fang EF. Lautrup S, et al. Cell Metab. 2019 Oct 1;30(4):630-655. doi: 10.1016/j.cmet.2019.09.001. Cell Metab. 2019. PMID: 31577933 Free PMC article. Review.
Multiple NAD(+)-dependent enzymes are involved in synaptic plasticity and neuronal stress resistance. ...Advances in understanding the molecular and cellular mechanisms of NAD(+)-based neuronal resilience will lead to novel approaches for facilitating healthy brain …
Multiple NAD(+)-dependent enzymes are involved in synaptic plasticity and neuronal stress resistance. ...Advances in understanding th …
Roles of NAD(+) in Health and Aging.
Lautrup S, Hou Y, Fang EF, Bohr VA. Lautrup S, et al. Cold Spring Harb Perspect Med. 2024 Jan 2;14(1):a041193. doi: 10.1101/cshperspect.a041193. Cold Spring Harb Perspect Med. 2024. PMID: 37848251 Free PMC article. Review.
NAD(+) levels decline with aging and in some age-related diseases, and reduction in NAD(+) affects all the hallmarks of aging. ...NAD supplementation has great future potential clinically, and these studies will also provide insight into the mec …
NAD(+) levels decline with aging and in some age-related diseases, and reduction in NAD(+) affects all the hallmarks of …
NAD(+) metabolism and its roles in cellular processes during ageing.
Covarrubias AJ, Perrone R, Grozio A, Verdin E. Covarrubias AJ, et al. Nat Rev Mol Cell Biol. 2021 Feb;22(2):119-141. doi: 10.1038/s41580-020-00313-x. Epub 2020 Dec 22. Nat Rev Mol Cell Biol. 2021. PMID: 33353981 Free PMC article. Review.
Many of these ageing-associated diseases can be slowed down and even reversed by restoring NAD(+) levels. ...However, much remains to be learnt about how NAD(+) influences human health and ageing biology. This includes a deeper understanding of the mol …
Many of these ageing-associated diseases can be slowed down and even reversed by restoring NAD(+) levels. ...However, much rem …
NAD(+) Metabolism in Cardiac Health, Aging, and Disease.
Abdellatif M, Sedej S, Kroemer G. Abdellatif M, et al. Circulation. 2021 Nov 30;144(22):1795-1817. doi: 10.1161/CIRCULATIONAHA.121.056589. Epub 2021 Nov 29. Circulation. 2021. PMID: 34843394
Pharmacological or genetic inhibition of NAD(+)-degrading enzymes, external supplementation of NAD(+) precursors, and transgenic overexpression of NAD(+)-generating enzymes have wide positive effects on metabolic health and age-associated diseases. NAD …
Pharmacological or genetic inhibition of NAD(+)-degrading enzymes, external supplementation of NAD(+) precursors, and transgen …
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD(+) and NMN levels.
Chini CCS, Peclat TR, Warner GM, Kashyap S, Espindola-Netto JM, de Oliveira GC, Gomez LS, Hogan KA, Tarragó MG, Puranik AS, Agorrody G, Thompson KL, Dang K, Clarke S, Childs BG, Kanamori KS, Witte MA, Vidal P, Kirkland AL, De Cecco M, Chellappa K, McReynolds MR, Jankowski C, Tchkonia T, Kirkland JL, Sedivy JM, van Deursen JM, Baker DJ, van Schooten W, Rabinowitz JD, Baur JA, Chini EN. Chini CCS, et al. Nat Metab. 2020 Nov;2(11):1284-1304. doi: 10.1038/s42255-020-00298-z. Epub 2020 Nov 16. Nat Metab. 2020. PMID: 33199925 Free PMC article.
Decreased NAD(+) levels have been shown to contribute to metabolic dysfunction during aging. NAD(+) decline can be partially prevented by knockout of the enzyme CD38. However, it is not known how CD38 is regulated during aging, and how its ecto-enzymat …
Decreased NAD(+) levels have been shown to contribute to metabolic dysfunction during aging. NAD(+) decline can be part …
Regulation of NAD(+) metabolism in aging and disease.
Chu X, Raju RP. Chu X, et al. Metabolism. 2022 Jan;126:154923. doi: 10.1016/j.metabol.2021.154923. Epub 2021 Oct 28. Metabolism. 2022. PMID: 34743990 Free PMC article. Review.
The biological functions of NAD(+) and NAD(+) precursors encompass pathways in cellular energetics, inflammation, metabolism, and cell survival. Several metabolic and neurological diseases exhibit reduced tissue NAD(+) levels. Significantly reduced levels of …
The biological functions of NAD(+) and NAD(+) precursors encompass pathways in cellular energetics, inflammation, metabolism, …
An NAD(+)-dependent metabolic checkpoint regulates hematopoietic stem cell activation and aging.
Song Z, Park SH, Mu WC, Feng Y, Wang CL, Wang Y, Barthez M, Maruichi A, Guo J, Yang F, Lin AW, Heydari K, Chini CCS, Chini EN, Jang C, Chen D. Song Z, et al. Nat Aging. 2024 Oct;4(10):1384-1393. doi: 10.1038/s43587-024-00670-8. Epub 2024 Jul 23. Nat Aging. 2024. PMID: 39044033 Free PMC article.
Conversely, aberrant CD38 upregulation during aging is a driver of HSC deterioration in aged mice due to dysregulated NAD(+) metabolism and compromised mitochondrial stress management. ...Pharmacological inactivation of CD38 reverses HSC aging and the pathoph …
Conversely, aberrant CD38 upregulation during aging is a driver of HSC deterioration in aged mice due to dysregulated NAD(+) m …
3,596 results