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1,650 results

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Page 1
Mitochondrial oxidative capacity and NAD(+) biosynthesis are reduced in human sarcopenia across ethnicities.
Migliavacca E, Tay SKH, Patel HP, Sonntag T, Civiletto G, McFarlane C, Forrester T, Barton SJ, Leow MK, Antoun E, Charpagne A, Seng Chong Y, Descombes P, Feng L, Francis-Emmanuel P, Garratt ES, Giner MP, Green CO, Karaz S, Kothandaraman N, Marquis J, Metairon S, Moco S, Nelson G, Ngo S, Pleasants T, Raymond F, Sayer AA, Ming Sim C, Slater-Jefferies J, Syddall HE, Fang Tan P, Titcombe P, Vaz C, Westbury LD, Wong G, Yonghui W, Cooper C, Sheppard A, Godfrey KM, Lillycrop KA, Karnani N, Feige JN. Migliavacca E, et al. Nat Commun. 2019 Dec 20;10(1):5808. doi: 10.1038/s41467-019-13694-1. Nat Commun. 2019. PMID: 31862890 Free PMC article.
Individuals with sarcopenia reproducibly demonstrate a prominent transcriptional signature of mitochondrial bioenergetic dysfunction in skeletal muscle, with low PGC-1alpha/ERRalpha signalling, and downregulation of oxidative phosphorylation and mitochondr …
Individuals with sarcopenia reproducibly demonstrate a prominent transcriptional signature of mitochondrial bioenergetic dysfunction …
ITGB2-mediated metabolic switch in CAFs promotes OSCC proliferation by oxidation of NADH in mitochondrial oxidative phosphorylation system.
Zhang X, Dong Y, Zhao M, Ding L, Yang X, Jing Y, Song Y, Chen S, Hu Q, Ni Y. Zhang X, et al. Theranostics. 2020 Oct 26;10(26):12044-12059. doi: 10.7150/thno.47901. eCollection 2020. Theranostics. 2020. PMID: 33204328 Free PMC article.
Accordingly, lactate derived from ITGB2-expressing CAFs was absorbed and metabolized in OSCC to generate NADH, which was then oxidized in the mitochondrial oxidative phosphorylation system (OXPHOS) to produce ATP. Notably, inhibiting the OXPHOS system with me …
Accordingly, lactate derived from ITGB2-expressing CAFs was absorbed and metabolized in OSCC to generate NADH, which was then oxidized in th …
Macrophage de novo NAD(+) synthesis specifies immune function in aging and inflammation.
Minhas PS, Liu L, Moon PK, Joshi AU, Dove C, Mhatre S, Contrepois K, Wang Q, Lee BA, Coronado M, Bernstein D, Snyder MP, Migaud M, Majeti R, Mochly-Rosen D, Rabinowitz JD, Andreasson KI. Minhas PS, et al. Nat Immunol. 2019 Jan;20(1):50-63. doi: 10.1038/s41590-018-0255-3. Epub 2018 Nov 26. Nat Immunol. 2019. PMID: 30478397 Free PMC article.
Isotope tracer studies revealed that macrophage NAD(+) derives substantially from KP metabolism of tryptophan. Genetic or pharmacological blockade of de novo NAD(+) synthesis depleted NAD(+), suppressed mitochondrial NAD(+)-dependent signaling a …
Isotope tracer studies revealed that macrophage NAD(+) derives substantially from KP metabolism of tryptophan. Genetic or pharmacolog …
Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.
Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA. Gomes AP, et al. Cell. 2013 Dec 19;155(7):1624-38. doi: 10.1016/j.cell.2013.11.037. Cell. 2013. PMID: 24360282 Free PMC article.
Ever since eukaryotes subsumed the bacterial ancestor of mitochondria, the nuclear and mitochondrial genomes have had to closely coordinate their activities, as each encode different subunits of the oxidative phosphorylation (OXPHOS) system. ...Deletin …
Ever since eukaryotes subsumed the bacterial ancestor of mitochondria, the nuclear and mitochondrial genomes have had to close …
Oxidative phosphorylation.
Griffiths DE. Griffiths DE. Essays Biochem. 1965;1:91-120. Essays Biochem. 1965. PMID: 4301986 Review. No abstract available.
The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon.
Donohoe DR, Garge N, Zhang X, Sun W, O'Connell TM, Bunger MK, Bultman SJ. Donohoe DR, et al. Cell Metab. 2011 May 4;13(5):517-26. doi: 10.1016/j.cmet.2011.02.018. Cell Metab. 2011. PMID: 21531334 Free PMC article.
Consequently, there is a marked decrease in NADH/NAD(+), oxidative phosphorylation, and ATP levels, which results in AMPK activation, p27(kip1) phosphorylation, and autophagy. When butyrate is added to germfree colonocytes, it rescues their deficit in …
Consequently, there is a marked decrease in NADH/NAD(+), oxidative phosphorylation, and ATP levels, which results in AM …
Homocysteine interferes with Ndufa1 leading to mitochondrial dysfunction through repression of the NAD(+)/Sirt1 pathway in the brain: a possible link between hyperhomocysteinemia and neurodegeneration.
Chai G, Mao Y, Gong J, Bi S, Zhang Y, Wu J, Yang L, Gao T, Fu H, Yu C, Ren C, Zhang G, Zhu X, Guan X, Yu H, Tang C, Nie Y, Yu H. Chai G, et al. Cell Death Dis. 2025 Jul 7;16(1):499. doi: 10.1038/s41419-025-07834-3. Cell Death Dis. 2025. PMID: 40624018 Free PMC article.
However, whether and how Hcy induces mitochondrial defects during the process of neurodegeneration is unclear. Here, we revealed that Hcy interfered with mitochondrial oxidative phosphorylation (OXPHOS) by inhibiting the mitochondrial electron t …
However, whether and how Hcy induces mitochondrial defects during the process of neurodegeneration is unclear. Here, we revealed that …
Enhancing mitochondrial proteostasis reduces amyloid-beta proteotoxicity.
Sorrentino V, Romani M, Mouchiroud L, Beck JS, Zhang H, D'Amico D, Moullan N, Potenza F, Schmid AW, Rietsch S, Counts SE, Auwerx J. Sorrentino V, et al. Nature. 2017 Dec 14;552(7684):187-193. doi: 10.1038/nature25143. Epub 2017 Dec 6. Nature. 2017. PMID: 29211722 Free PMC article.
Here we provide bioinformatic and experimental evidence of a conserved mitochondrial stress response signature present in diseases involving amyloid-beta proteotoxicity in human, mouse and Caenorhabditis elegans that involves the mitochondrial unfolded protein respo …
Here we provide bioinformatic and experimental evidence of a conserved mitochondrial stress response signature present in diseases in …
Mitochondrial Oxidative Phosphorylation defect in the Heart of Subjects with Coronary Artery Disease.
Ait-Aissa K, Blaszak SC, Beutner G, Tsaih SW, Morgan G, Santos JH, Flister MJ, Joyce DL, Camara AKS, Gutterman DD, Donato AJ, Porter GA Jr, Beyer AM. Ait-Aissa K, et al. Sci Rep. 2019 May 20;9(1):7623. doi: 10.1038/s41598-019-43761-y. Sci Rep. 2019. PMID: 31110224 Free PMC article.
Fresh and frozen human heart tissue was used. Cell lysate or mitochondria were isolated using standard techniques. Mitochondrial DNA ((mt)DNA), NAD + and ATP levels, and mitochondrial oxidative phosphorylation capacity were evaluated. ... …
Fresh and frozen human heart tissue was used. Cell lysate or mitochondria were isolated using standard techniques. Mitochondrial …
An NADH-controlled gatekeeper of ATP synthase.
Schildhauer F, Ryl PSJ, Lauer SM, Lenz S, Barlas AB, Ouzounidis VR, Jeffrey K, Marcu DC, O'Reilly FJ, Graziadei A, Stuiver M, Schmidt K, Ewers H, Spahn CMT, Karaca E, Busch KE, Cheerambathur D, Schwefel D, Rappsilber J. Schildhauer F, et al. Mol Cell. 2025 Jul 3;85(13):2567-2580.e12. doi: 10.1016/j.molcel.2025.06.007. Epub 2025 Jun 26. Mol Cell. 2025. PMID: 40578349 Free article.
ATP fuels crucial cellular processes and is obtained mostly by oxidative phosphorylation (OXPHOS) at the inner mitochondrial membrane. While significant progress has been made in mechanistic understanding of ATP production, critical aspects surrounding its su …
ATP fuels crucial cellular processes and is obtained mostly by oxidative phosphorylation (OXPHOS) at the inner mitochondria …
1,650 results