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NADPH oxidase hyperactivity induces plantaris atrophy in heart failure rats.
Bechara LR, Moreira JB, Jannig PR, Voltarelli VA, Dourado PM, Vasconcelos AR, Scavone C, Ramires PR, Brum PC. Bechara LR, et al. Int J Cardiol. 2014 Aug 20;175(3):499-507. doi: 10.1016/j.ijcard.2014.06.046. Epub 2014 Jul 2. Int J Cardiol. 2014. PMID: 25023789
NADPH oxidase inhibition by apocynin prevented MI-induced skeletal muscle atrophy by reducing ROS production, NF-kappaB hyperactivation, p38 MAPK phosphorylation and proteasomal hyperactivity. CONCLUSION: Our data provide evidence
NADPH oxidase inhibition by apocynin prevented MI-induced skeletal muscle atrophy by reducing ROS
Exercise training decreases NADPH oxidase activity and restores skeletal muscle mass in heart failure rats.
Cunha TF, Bechara LR, Bacurau AV, Jannig PR, Voltarelli VA, Dourado PM, Vasconcelos AR, Scavone C, Ferreira JC, Brum PC. Cunha TF, et al. J Appl Physiol (1985). 2017 Apr 1;122(4):817-827. doi: 10.1152/japplphysiol.00182.2016. Epub 2017 Jan 19. J Appl Physiol (1985). 2017. PMID: 28104751 Free article.
We have recently demonstrated that NADPH oxidase hyperactivity, NF-kappaB activation, and increased p38 phosphorylation lead to atrophy of glycolytic muscle in heart failure (HF). ...These molecular changes counteract plantaris
We have recently demonstrated that NADPH oxidase hyperactivity, NF-kappaB activation, and increased p38 phosphorylation …