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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1972 1
1974 1
1975 2
1976 3
1977 6
1978 6
1979 7
1980 13
1981 10
1982 20
1983 29
1984 29
1985 24
1986 29
1987 29
1988 34
1989 41
1990 43
1991 49
1992 85
1993 75
1994 101
1995 97
1996 81
1997 107
1998 117
1999 91
2000 74
2001 82
2002 80
2003 94
2004 89
2005 101
2006 99
2007 127
2008 119
2009 119
2010 136
2011 154
2012 147
2013 173
2014 152
2015 142
2016 155
2017 153
2018 171
2019 175
2020 160
2021 145
2022 80
2023 83
2024 97
2025 129
2026 70

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4,039 results

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Page 1
The diverse functionality of NQO1 and its roles in redox control.
Ross D, Siegel D. Ross D, et al. Redox Biol. 2021 May;41:101950. doi: 10.1016/j.redox.2021.101950. Epub 2021 Mar 20. Redox Biol. 2021. PMID: 33774477 Free PMC article. Review.
Since NQO1 is highly expressed in many solid tumors, including via upregulation of Nrf2, the design of compounds activated by NQO1 and NQO1-targeted drug delivery have been active areas of research. Endogenous substrates have also been proposed and of relevance to r …
Since NQO1 is highly expressed in many solid tumors, including via upregulation of Nrf2, the design of compounds activated by NQO1 an …
Emodin inhibited NADPH-quinone reductase competitively and induced cytotoxicity in rat primary hepatocytes.
Shukla V, Asthana S, Yadav S, Rajput VS, Tripathi A. Shukla V, et al. Toxicon. 2020 Dec;188:117-121. doi: 10.1016/j.toxicon.2020.10.018. Epub 2020 Oct 22. Toxicon. 2020. PMID: 33122156
Here, we report that Emodin, a CO anthraquinone, inhibits the enzymatic activity of NADPH-Quinone reductase, which is an intracellular enzyme fundamentally involved in the detoxification of quinone containing compounds. Emodin binds to the ac …
Here, we report that Emodin, a CO anthraquinone, inhibits the enzymatic activity of NADPH-Quinone reductase, whi …
Role of NADPH Quinone Reductase 1 (NQO1) Polymorphism in Prevention, Diagnosis, and Treatment of Gastrointestinal Cancers.
Ghorbani F, Mazidimoradi A, Biyabani A, Allahqoli L, Salehiniya H. Ghorbani F, et al. Curr Cancer Drug Targets. 2024;24(12):1213-1221. doi: 10.2174/0115680096283149240109094710. Curr Cancer Drug Targets. 2024. PMID: 38318828 Review.
The existence of single nucleotide polymorphisms (SNPs) of NADPH Quinone Reductase 1 (NQO1), such as 609C>T NQO1, leads to a decrease in NQO1 enzyme activity. ...
The existence of single nucleotide polymorphisms (SNPs) of NADPH Quinone Reductase 1 (NQO1), such as 609C>T NQO1, le …
NADPH-specific quinone reductase is induced by 2-methylene-4-butyrolactone in Escherichia coli.
Hayashi M, Ohzeki H, Shimada H, Unemoto T. Hayashi M, et al. Biochim Biophys Acta. 1996 Feb 15;1273(2):165-70. doi: 10.1016/0005-2728(95)00138-7. Biochim Biophys Acta. 1996. PMID: 8611590 Free article.
2-Methylene-4-butyrolactone (MBL), an inducer of NAD(P)H:(quinone acceptor) oxidoreductase (EC 1.699.2) in animal cells, was found to induce NADPH-specific quinone reductase about 25-fold in Escherichia coli. ...Both enzymes reacte …
2-Methylene-4-butyrolactone (MBL), an inducer of NAD(P)H:(quinone acceptor) oxidoreductase (EC 1.699.2) in anima …
[DT-diaphorase].
Mikami K, Shirakusa T, Tsuruo T. Mikami K, et al. Gan To Kagaku Ryoho. 1997 Sep;24(11):1606-10. Gan To Kagaku Ryoho. 1997. PMID: 9309161 Review. Japanese.
Anti-tumor quinone, including mitomycin C (MMC), needs to be activated by bioreduction to exert its cytotoxic activities. The enzymes underlying this bioreductive activation have been the subject of extensive research on Mitomycin C. Cytochrome P450 …
Anti-tumor quinone, including mitomycin C (MMC), needs to be activated by bioreduction to exert its cytotoxic activities …
The NADPH quinone reductase MdaB confers oxidative stress resistance to Helicobacter hepaticus.
Hong Y, Wang G, Maier RJ. Hong Y, et al. Microb Pathog. 2008 Feb;44(2):169-74. doi: 10.1016/j.micpath.2006.08.005. Epub 2007 Sep 6. Microb Pathog. 2008. PMID: 17923370 Free PMC article.
An mdaB mutant strain in a quinone reductase (MdaB) of Helicobacter hepaticus type strain ATCC51449 was constructed by insertional mutagenesis, and the MdaB protein was purified and compared to the Helicobacter pylori enzyme. ...H. hepaticus MdaB is a flavoprotein c …
An mdaB mutant strain in a quinone reductase (MdaB) of Helicobacter hepaticus type strain ATCC51449 was constructed by inserti …
A novel Xanthomonas citri subsp. citri NADPH quinone reductase involved in salt stress response and virulence.
Barcarolo MV, Garavaglia BS, Gottig N, Ceccarelli EA, Catalano-Dupuy DL, Ottado J. Barcarolo MV, et al. Biochim Biophys Acta Gen Subj. 2020 Mar;1864(3):129514. doi: 10.1016/j.bbagen.2020.129514. Epub 2020 Jan 3. Biochim Biophys Acta Gen Subj. 2020. PMID: 31911239
Xac2229 is a FAD containing flavoprotein, displays diaphorase activity with an optimum at pH 6.0 and has quinone reductase activity using NADPH as an electron donor. CONCLUSIONS: A FAD containing flavoprotein from Xcc is a new NADPH qu …
Xac2229 is a FAD containing flavoprotein, displays diaphorase activity with an optimum at pH 6.0 and has quinone reductase …
Retention of NADPH-linked quinone reductase activity in an aldo-keto reductase following mutation of the catalytic tyrosine.
Schlegel BP, Ratnam K, Penning TM. Schlegel BP, et al. Biochemistry. 1998 Aug 4;37(31):11003-11. doi: 10.1021/bi980475r. Biochemistry. 1998. PMID: 9692994
The Ea for 9,10-PQ reduction was unchanged in the Tyr 55 mutants, suggesting that the reaction proceeds through the same low-energy barrier in the wild-type enzyme and these mutants. The retention of quinone reductase activity in this AKR in the absence of Ty …
The Ea for 9,10-PQ reduction was unchanged in the Tyr 55 mutants, suggesting that the reaction proceeds through the same low-energy barrier …
Human carbonyl reductase 4 is a mitochondrial NADPH-dependent quinone reductase.
Endo S, Matsunaga T, Kitade Y, Ohno S, Tajima K, El-Kabbani O, Hara A. Endo S, et al. Biochem Biophys Res Commun. 2008 Dec 26;377(4):1326-30. doi: 10.1016/j.bbrc.2008.11.003. Epub 2008 Nov 10. Biochem Biophys Res Commun. 2008. PMID: 19000905
A protein encoded in the gene Cbr4 on human chromosome 4q32.3 belongs to the short-chain dehydrogenase/reductase family. Contrary to the functional annotation as carbonyl reductase 4 (CBR4), we show that the recombinant tetrameric protein, composed of 25-kDa …
A protein encoded in the gene Cbr4 on human chromosome 4q32.3 belongs to the short-chain dehydrogenase/reductase family. Contr …
Restenosis revisited.
Calvert PA, Bennett MR. Calvert PA, et al. Circ Res. 2009 Apr 10;104(7):823-5. doi: 10.1161/CIRCRESAHA.109.196345. Circ Res. 2009. PMID: 19359603 Free article. No abstract available.
4,039 results