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Hemodynamics during the 10-minute NASA Lean Test: evidence of circulatory decompensation in a subset of ME/CFS patients.
Lee J, Vernon SD, Jeys P, Ali W, Campos A, Unutmaz D, Yellman B, Bateman L. Lee J, et al. J Transl Med. 2020 Aug 15;18(1):314. doi: 10.1186/s12967-020-02481-y. J Transl Med. 2020. PMID: 32799889 Free PMC article.
The 10-minute NASA Lean Test (NLT) is a simple, point-of-care method that can aid ME/CFS diagnosis and guide management and treatment of OI. ...The 10-minute NLT involves measurement of blood pressure and heart rate while resting supine and every minute for 1 …
The 10-minute NASA Lean Test (NLT) is a simple, point-of-care method that can aid ME/CFS diagnosis and guide management …
Comparison of the head-up tilt test and the 10-minute NASA lean test for assessing blood pressure and heart rate responses in young individuals with postacute COVID-19 syndrome.
Sathaporn N, Timinkul A, Panwong W, Pipatbanjong P, Dangwisut T, Phusabsin P, Promjun K, Kluayhomthong S. Sathaporn N, et al. Blood Press Monit. 2025 Aug 1;30(4):153-160. doi: 10.1097/MBP.0000000000000749. Epub 2025 Mar 18. Blood Press Monit. 2025. PMID: 40105186
BACKGROUND: Individuals with postacute COVID-19 syndrome (PACS) typically exhibit abnormal hemodynamic responses during upright positioning, including orthostatic hypotension and postural orthostatic tachycardia syndrome. The 10-minute NASA lean tes
BACKGROUND: Individuals with postacute COVID-19 syndrome (PACS) typically exhibit abnormal hemodynamic responses during upright positioning, …
Association of circulating biomarkers with illness severity measures differentiates myalgic encephalomyelitis/chronic fatigue syndrome and post-COVID-19 condition: a prospective pilot cohort study.
Domingo JC, Battistini F, Cordobilla B, Zaragozá MC, Sanmartin-Sentañes R, Alegre-Martin J, Cambras T, Castro-Marrero J. Domingo JC, et al. J Transl Med. 2024 Apr 10;22(1):343. doi: 10.1186/s12967-024-05148-0. J Transl Med. 2024. PMID: 38600563 Free PMC article.
All study participants underwent non-invasive cardiovascular hemodynamic challenge testing (10 min NASA lean test) for assessment of orthostatic intolerance. Regression analysis was used to examine associations between outcome measures and circulating …
All study participants underwent non-invasive cardiovascular hemodynamic challenge testing (10 min NASA lean test) for …
Prevalence of orthostatic intolerance in long covid clinic patients and healthy volunteers: A multicenter study.
Lee C, Greenwood DC, Master H, Balasundaram K, Williams P, Scott JT, Wood C, Cooper R, Darbyshire JL, Gonzalez AE, Davies HE, Osborne T, Corrado J, Iftekhar N, Rogers N, Delaney B, Greenhalgh T, Sivan M; LOCOMOTION Consortium. Lee C, et al. J Med Virol. 2024 Mar;96(3):e29486. doi: 10.1002/jmv.29486. J Med Virol. 2024. PMID: 38456315
Orthostatic intolerance (OI), including postural orthostatic tachycardia syndrome (PoTS) and orthostatic hypotension (OH), are often reported in long covid, but published studies are small with inconsistent results. ...Participants with a diagnosis of long co
Orthostatic intolerance (OI), including postural orthostatic tachycardia syndrome (PoTS) and orthostatic hypotension (O
Detecting Orthostatic Intolerance in Long COVID in a Clinic Setting.
Isaac RO, Corrado J, Sivan M. Isaac RO, et al. Int J Environ Res Public Health. 2023 May 12;20(10):5804. doi: 10.3390/ijerph20105804. Int J Environ Res Public Health. 2023. PMID: 37239531 Free PMC article.
INTRODUCTION: A likely mechanism of Long COVID (LC) is dysautonomia, manifesting as orthostatic intolerance (OI). In our LC service, all patients underwent a National Aeronautics and Space Administration (NASA) Lean Test (NL …
INTRODUCTION: A likely mechanism of Long COVID (LC) is dysautonomia, manifesting as orthostatic intolerance (OI). In our LC service, …
Postural orthostatic tachycardia syndrome and orthostatic hypotension in post-acute sequelae of COVID-19 during pregnancy: a case report.
Hanson J, Richley M, Hsu JJ, Lin J, Afshar Y. Hanson J, et al. Eur Heart J Case Rep. 2022 Nov 30;6(12):ytac453. doi: 10.1093/ehjcr/ytac453. eCollection 2022 Dec. Eur Heart J Case Rep. 2022. PMID: 36518330 Free PMC article.
The patient then had complete resolution of COVID-19 symptoms and felt well for 1 month prior to developing orthostatic symptoms at 25 weeks of gestation. Evaluation with a NASA Lean Test revealed marked orthostatic tachycardia, as well as delay …
The patient then had complete resolution of COVID-19 symptoms and felt well for 1 month prior to developing orthostatic symptoms at 2 …
Orthostatic Challenge Causes Distinctive Symptomatic, Hemodynamic and Cognitive Responses in Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
Vernon SD, Funk S, Bateman L, Stoddard GJ, Hammer S, Sullivan K, Bell J, Abbaszadeh S, Lipkin WI, Komaroff AL. Vernon SD, et al. Front Med (Lausanne). 2022 Jun 23;9:917019. doi: 10.3389/fmed.2022.917019. eCollection 2022. Front Med (Lausanne). 2022. PMID: 35847821 Free PMC article.
METHODS: We evaluated whether a simple, standardized, office-based test of OI, the 10-min NASA Lean Test (NLT), would aggravate symptoms and produce objective hemodynamic and cognitive abnormalities, the latter being evaluated by a simple smart phone-b …
METHODS: We evaluated whether a simple, standardized, office-based test of OI, the 10-min NASA Lean Test (NLT), …
Resistance exercise training and the orthostatic response.
McCarthy JP, Bamman MM, Yelle JM, LeBlanc AD, Rowe RM, Greenisen MC, Lee SM, Spector ER, Fortney SM; New Collective Author. McCarthy JP, et al. Eur J Appl Physiol Occup Physiol. 1997;76(1):32-40. doi: 10.1007/s004210050209. Eur J Appl Physiol Occup Physiol. 1997. PMID: 9243167
Resistance exercise has been suggested to increase blood volume, increase the sensitivity of the carotid baroreceptor cardiac reflex response (BARO), and decrease leg compliance, all factors that are expected to improve orthostatic tolerance. To further test these h …
Resistance exercise has been suggested to increase blood volume, increase the sensitivity of the carotid baroreceptor cardiac reflex respons …
Dysautonomia in Long COVID is Prevalent and Could Explain the Frequency of Symptoms.
Tamariz L, Rozenfeld I, Iglesias R, Bast E, Avecillas S, Shehadeh L, Klimas N, Palacio A. Tamariz L, et al. Clin Med Res. 2026 Mar;24(1):28-34. doi: 10.3121/cmr.2025.2054. Clin Med Res. 2026. PMID: 41951431 Free PMC article.
Our aim was to evaluate the prevalence of autonomic dysfunction in long COVID patients.Methods: We conducted a cross-sectional study and included all consecutive patients enrolled in several clinical research studies. We performed the following autonomic dysfunction marker …
Our aim was to evaluate the prevalence of autonomic dysfunction in long COVID patients.Methods: We conducted a cross-sectional study and inc …
12 results