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CHK1 inhibition exacerbates replication stress induced by IGF blockade.
Wu X, Seraia E, Hatch SB, Wan X, Ebner DV, Aroldi F, Jiang Y, Ryan AJ, Bogenrieder T, Weyer-Czernilofsky U, Rieunier G, Macaulay VM. Wu X, et al. Oncogene. 2022 Jan;41(4):476-488. doi: 10.1038/s41388-021-02080-1. Epub 2021 Nov 12. Oncogene. 2022. PMID: 34773074 Free PMC article.
Epigallocatechin-3-gallate inhibits the growth of three-dimensional in vitro models of neuroblastoma cell SH-SY5Y.
Wan X, Wang W, Liang Z. Wan X, et al. Mol Cell Biochem. 2021 Aug;476(8):3141-3148. doi: 10.1007/s11010-021-04154-w. Epub 2021 Apr 16. Mol Cell Biochem. 2021. PMID: 33860868 Free PMC article.
In this study, novel 3D in vitro models of neuroblastoma were established in the application of testing a potential anti-cancer candidate compound EGCG. In pursuit of the goals of the 3Rs (replacement, reduction and refinement), the usage of these 3D in vitro models has th …
In this study, novel 3D in vitro models of neuroblastoma were established in the application of testing a potential anti-cancer candidate co …
ReN VM spheroids in matrix: A neural progenitor three-dimensional in vitro model reveals DYRK1A inhibitors as potential regulators of radio-sensitivity.
Wan X, Wu X, Hill MA, Ebner DV. Wan X, et al. Biochem Biophys Res Commun. 2020 Oct 22;531(4):535-542. doi: 10.1016/j.bbrc.2020.07.130. Epub 2020 Aug 14. Biochem Biophys Res Commun. 2020. PMID: 32807492
These features include an extracellular matrix, co-culture, tension and perfusion and could replace several hundred rodents in the drug screening validation cascade. ...
These features include an extracellular matrix, co-culture, tension and perfusion and could replace several hundred rodents in the dr …
Morphological analysis of human umbilical vein endothelial cells co-cultured with ovarian cancer cells in 3D: An oncogenic angiogenesis assay.
Wan X, Bovornchutichai P, Cui Z, O'Neill E, Ye H. Wan X, et al. PLoS One. 2017 Jul 3;12(7):e0180296. doi: 10.1371/journal.pone.0180296. eCollection 2017. PLoS One. 2017. PMID: 28671994 Free PMC article.
Animal testing is still the most common method used for evaluating the efficacy of new drugs but tissue-engineered in vitro models are becoming more acceptable for replacing and reducing the use of animals in anti-cancer drug screening. ...
Animal testing is still the most common method used for evaluating the efficacy of new drugs but tissue-engineered in vitro models are becom …