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Page 1
NF2-Related Schwannomatosis.
Evans DG. Evans DG. 1998 Oct 14 [updated 2023 Apr 20]. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2026. 1998 Oct 14 [updated 2023 Apr 20]. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2026. PMID: 20301380 Free Books & Documents. Review.
GENETIC COUNSELING: NF2 is inherited in an autosomal dominant manner. Approximately 50% of individuals diagnosed with NF2 have an affected parent. Approximately 50% of individuals diagnosed with NF2 have the disorder as the result of a de novo NF2 path …
GENETIC COUNSELING: NF2 is inherited in an autosomal dominant manner. Approximately 50% of individuals diagnosed with NF2 have …
NF2 alteration in mesothelioma.
Sekido Y, Sato T. Sekido Y, et al. Front Toxicol. 2023 Apr 25;5:1161995. doi: 10.3389/ftox.2023.1161995. eCollection 2023. Front Toxicol. 2023. PMID: 37180489 Free PMC article. Review.
The NF2 tumor suppressor gene is a frequent somatically mutated gene in mesothelioma, with 30%-40% mesotheliomas showing NF2 inactivation. ...Recent genome analysis revealed that NF2 alteration may be a late event in mesothelioma development, suggesting that …
The NF2 tumor suppressor gene is a frequent somatically mutated gene in mesothelioma, with 30%-40% mesotheliomas showing NF2 i …
The molecular biology of NF2/Merlin on tumorigenesis and development.
Vlashi R, Sun F, Zheng C, Zhang X, Liu J, Chen G. Vlashi R, et al. FASEB J. 2024 Jul 15;38(13):e23809. doi: 10.1096/fj.202400019RR. FASEB J. 2024. PMID: 38967126 Review.
The neurofibromatosis type 2 (NF2) gene, known for encoding the tumor suppressor protein Merlin, is central to the study of tumorigenesis and associated cellular processes. ...This synthesis of current knowledge underscores the necessity for ongoing research to elucidate t …
The neurofibromatosis type 2 (NF2) gene, known for encoding the tumor suppressor protein Merlin, is central to the study of tumorigen …
NF2: An underestimated player in cancer metabolic reprogramming and tumor immunity.
Xu D, Yin S, Shu Y. Xu D, et al. NPJ Precis Oncol. 2024 Jun 15;8(1):133. doi: 10.1038/s41698-024-00627-5. NPJ Precis Oncol. 2024. PMID: 38879686 Free PMC article. Review.
Neurofibromatosis type 2 (NF2) is a tumor suppressor gene implicated in various tumors, including mesothelioma, schwannomas, and meningioma. ...This review may provide a deeper understanding of the biological roles of NF2 and guide possible therapeutic avenues....
Neurofibromatosis type 2 (NF2) is a tumor suppressor gene implicated in various tumors, including mesothelioma, schwannomas, and meni …
Role of NF2 Mutation in the Development of Eleven Different Cancers.
Nouri SH, Nitturi V, Ledbetter E, English CW, Lau S, Klisch TJ, Patel AJ. Nouri SH, et al. Cancers (Basel). 2024 Dec 29;17(1):64. doi: 10.3390/cancers17010064. Cancers (Basel). 2024. PMID: 39796693 Free PMC article. Review.
Of note were key biological pathways implicated in cancer formation resulting from sporadic NF2 mutations. Results: NF2 gene mutations are implicated in over 11 different cancers, including several CNS tumors, soli-organ tumors, and skin cancer. ...However, future s …
Of note were key biological pathways implicated in cancer formation resulting from sporadic NF2 mutations. Results: NF2 gene m …
NF2-Related Schwannomatosis (NF2): Molecular Insights and Therapeutic Avenues.
Kim BH, Chung YH, Woo TG, Kang SM, Park S, Kim M, Park BJ. Kim BH, et al. Int J Mol Sci. 2024 Jun 14;25(12):6558. doi: 10.3390/ijms25126558. Int J Mol Sci. 2024. PMID: 38928264 Free PMC article. Review.
NF2-related schwannomatosis (NF2) is a genetic syndrome characterized by the growth of benign tumors in the nervous system, particularly bilateral vestibular schwannomas, meningiomas, and ependymomas. This review consolidates the current knowledge on NF2 synd …
NF2-related schwannomatosis (NF2) is a genetic syndrome characterized by the growth of benign tumors in the nervous system, pa …
MEF2C silencing downregulates NF2 and E-cadherin and enhances Erastin-induced ferroptosis in meningioma.
Bao Z, Hua L, Ye Y, Wang D, Li C, Xie Q, Wakimoto H, Gong Y, Ji J. Bao Z, et al. Neuro Oncol. 2021 Dec 1;23(12):2014-2027. doi: 10.1093/neuonc/noab114. Neuro Oncol. 2021. PMID: 33984142 Free PMC article.
Although cell density-dependent E-cadherin and Merlin/Neurofibromin (NF2) loss can modulate ferroptosis, the role of ferroptosis and its potential link to NF2 status and E-cadherin expression in meningioma remain unknown. METHODS: Relationship between ferroptosis mo …
Although cell density-dependent E-cadherin and Merlin/Neurofibromin (NF2) loss can modulate ferroptosis, the role of ferroptosis and …
The Role of Merlin/NF2 Loss in Meningioma Biology.
Lee S, Karas PJ, Hadley CC, Bayley V JC, Khan AB, Jalali A, Sweeney AD, Klisch TJ, Patel AJ. Lee S, et al. Cancers (Basel). 2019 Oct 24;11(11):1633. doi: 10.3390/cancers11111633. Cancers (Basel). 2019. PMID: 31652973 Free PMC article. Review.
Mutations in the neurofibromin 2 (NF2) gene were among the first genetic alterations implicated in meningioma tumorigenesis, based on analysis of neurofibromatosis type 2 (NF2) patients who not only develop vestibular schwannomas but later have a high incidence of m …
Mutations in the neurofibromin 2 (NF2) gene were among the first genetic alterations implicated in meningioma tumorigenesis, based on …
NF2 is Essential for Human Endoderm Development.
Jeong M, Han D, Bhetariya P, Welling DB, Stojkovic M, Stankovic KM. Jeong M, et al. Adv Sci (Weinh). 2025 May;12(17):e2410909. doi: 10.1002/advs.202410909. Epub 2025 Feb 8. Adv Sci (Weinh). 2025. PMID: 39921490 Free PMC article.
People with heterozygous NF2 mutations typically develop Schwann cell tumors, especially vestibular schwannoma, but the specific role of NF2 in human embryonic development is unclear. ...Endoderm formation can be rescued via YAP1 knockdown or forced re-expression of …
People with heterozygous NF2 mutations typically develop Schwann cell tumors, especially vestibular schwannoma, but the specific role …
NF2: the wizardry of merlin.
Xiao GH, Chernoff J, Testa JR. Xiao GH, et al. Genes Chromosomes Cancer. 2003 Dec;38(4):389-99. doi: 10.1002/gcc.10282. Genes Chromosomes Cancer. 2003. PMID: 14566860 Review.
The NF2 gene is also implicated in the development of sporadic schwannomas and meningiomas, as well as tumor types seemingly unrelated to the NF2 disorder, such as malignant mesotheliomas. Inactivation of NF2 occurs by a "two-hit" mechanism, as proposed by Al …
The NF2 gene is also implicated in the development of sporadic schwannomas and meningiomas, as well as tumor types seemingly unrelate …
3,518 results