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Liberal Versus Restrictive Intravenous Fluid Therapy for Early Septic Shock: Rationale for a Randomized Trial.
Self WH, Semler MW, Bellomo R, Brown SM, deBoisblanc BP, Exline MC, Ginde AA, Grissom CK, Janz DR, Jones AE, Liu KD, Macdonald SPJ, Miller CD, Park PK, Reineck LA, Rice TW, Steingrub JS, Talmor D, Yealy DM, Douglas IS, Shapiro NI; CLOVERS Protocol Committee and NHLBI Prevention and Early Treatment of Acute Lung Injury (PETAL) Network Investigators. Self WH, et al. Ann Emerg Med. 2018 Oct;72(4):457-466. doi: 10.1016/j.annemergmed.2018.03.039. Epub 2018 May 10. Ann Emerg Med. 2018. PMID: 29753517 Free PMC article.
Two competing strategies are emerging: a liberal fluids approach, consisting of a larger volume of initial fluid (50 to 75 mL/kg [4 to 6 L in an 80-kg adult] during the first 6 hours) and later use of vasopressors, versus a restrictive fluids approach, consisting of a smaller vol …
Two competing strategies are emerging: a liberal fluids approach, consisting of a larger volume of initial fluid (50 to 75 mL/kg [4 to 6 L i …
Recall of clinical trial participation and attrition rates in survivors of acute respiratory distress syndrome.
Carlton EF, Ice E, Barbaro RP, Kampuis L, Moss M, Angus DC, Banner-Goodspeed VM, Ginde AA, Gong MN, Grissom CK, Hou PC, Huang DT, Hough CTL, Talmor DS, Thompson BT, Yealy DM, Couper MP, Iwashyna TJ; NHLBI Prevention and Early Treatment of Acute Lung Injury (PETAL) Network. Carlton EF, et al. J Crit Care. 2021 Aug;64:160-164. doi: 10.1016/j.jcrc.2021.04.006. Epub 2021 Apr 17. J Crit Care. 2021. PMID: 33906105 Free PMC article.
Significant Variability in Surrogate Informed Consent Rates in ARDS and Prevention and Early Treatment of Acute Lung Injury Network Multicenter Trials.
Lane T, Sottile PD, Peterson R, Jin Y, Moss M; NHLBI Prevention and Early Treatment of Acute Lung Injury (PETAL) Network Investigators. Lane T, et al. Chest. 2022 May;161(5):1306-1309. doi: 10.1016/j.chest.2021.09.008. Epub 2021 Sep 17. Chest. 2022. PMID: 34543666 Free PMC article. No abstract available.
Financial Toxicity After Acute Respiratory Distress Syndrome: A National Qualitative Cohort Study.
Hauschildt KE, Seigworth C, Kamphuis LA, Hough CL, Moss M, McPeake JM, Iwashyna TJ; National Heart, Lung, and Blood Institute (NHLBI) Prevention and Early Treatment of Acute Lung Injury (PETAL) Network. Hauschildt KE, et al. Crit Care Med. 2020 Aug;48(8):1103-1110. doi: 10.1097/CCM.0000000000004378. Crit Care Med. 2020. PMID: 32697479 Free PMC article.
We recruited consecutive surviving patients who were English speaking, consented to follow-up, and were randomized between December 11, 2017, and May 4, 2018 (n = 79) from 29 U.S. sites. MEASUREMENTS AND MAIN RESULTS: We asked about patients' perceptions of financia …
We recruited consecutive surviving patients who were English speaking, consented to follow-up, and were randomized between December 11, 2017 …
The Nature and Variability of Automated Practice Alerts Derived from Electronic Health Records in a U.S. Nationwide Critical Care Research Network.
Benthin C, Pannu S, Khan A, Gong M; NHLBI Prevention and Early Treatment of Acute Lung Injury (PETAL) Network. Benthin C, et al. Ann Am Thorac Soc. 2016 Oct;13(10):1784-1788. doi: 10.1513/AnnalsATS.201603-172BC. Ann Am Thorac Soc. 2016. PMID: 27404288 Free PMC article.
METHODS: We surveyed investigators at 38 institutions involved in the National Institutes of Health-funded Clinical Trials Network for the Prevention and Early Treatment of Acute Lung Injury (PETAL) for quantitative and qualitative analysis. ...
METHODS: We surveyed investigators at 38 institutions involved in the National Institutes of Health-funded Clinical Trials Network fo …
Nonlinear Imputation of PaO2/FIO2 From SpO2/FIO2 Among Mechanically Ventilated Patients in the ICU: A Prospective, Observational Study.
Brown SM, Duggal A, Hou PC, Tidswell M, Khan A, Exline M, Park PK, Schoenfeld DA, Liu M, Grissom CK, Moss M, Rice TW, Hough CL, Rivers E, Thompson BT, Brower RG; National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute (NHLBI) Prevention and Early Treatment of Acute Lung Injury (PETAL) Network. Brown SM, et al. Crit Care Med. 2017 Aug;45(8):1317-1324. doi: 10.1097/CCM.0000000000002514. Crit Care Med. 2017. PMID: 28538439 Free PMC article.
OBJECTIVES: In the contemporary ICU, mechanically ventilated patients may not have arterial blood gas measurements available at relevant timepoints. Severity criteria often depend on arterial blood gas results. ...INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: …
OBJECTIVES: In the contemporary ICU, mechanically ventilated patients may not have arterial blood gas measurements available at relev …
Continuing Cardiopulmonary Symptoms, Disability, and Financial Toxicity 1 Month After Hospitalization for Third-Wave COVID-19: Early Results From a US Nationwide Cohort.
Iwashyna TJ, Kamphuis LA, Gundel SJ, Hope AA, Jolley S, Admon AJ, Caldwell E, Monahan ML, Hauschildt K, Thompson BT, Hough CL; NHLBI Prevention and Early Treatment of Acute Lung Injury (PETAL) Network. Iwashyna TJ, et al. J Hosp Med. 2021 Aug 18. doi: 10.12788/jhm.3660. Online ahead of print. J Hosp Med. 2021. PMID: 34424190
DESIGN, SETTING, AND PARTICIPANTS: Preplanned early look at 1-month follow-up surveys from patients hospitalized August 2020 to January 2021 in NHLBI PETAL Network's Biology and Longitudinal Epidemiology: COVID-19 Observational (BLUE CORAL) study. ...
DESIGN, SETTING, AND PARTICIPANTS: Preplanned early look at 1-month follow-up surveys from patients hospitalized August 2020 to January 2021 …
Power Calculations to Select Instruments for Clinical Trial Secondary Endpoints. A Case Study of Instrument Selection for Post-Traumatic Stress Symptoms in Subjects with Acute Respiratory Distress Syndrome.
Sjoding MW, Schoenfeld DA, Brown SM, Hough CL, Yealy DM, Moss M, Angus DC, Iwashyna TJ; NHLBI Prevention and Early Treatment of Acute Lung Injury (PETAL) Network. Sjoding MW, et al. Ann Am Thorac Soc. 2017 Jan;14(1):110-117. doi: 10.1513/AnnalsATS.201608-585OC. Ann Am Thorac Soc. 2017. PMID: 27788018 Free PMC article.