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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1996 2
1997 2
1998 3
1999 7
2000 2
2001 5
2002 5
2003 7
2004 5
2005 10
2006 10
2007 15
2008 18
2009 20
2010 21
2011 19
2012 29
2013 29
2014 24
2015 25
2016 25
2017 17
2018 26
2019 14
2020 17
2021 10
2022 1
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319 results
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Page 1
Genetic Origins of Tetralogy of Fallot.
Morgenthau A, Frishman WH. Morgenthau A, et al. Cardiol Rev. 2018 Mar/Apr;26(2):86-92. doi: 10.1097/CRD.0000000000000170. Cardiol Rev. 2018. PMID: 29045289 Review.
Due to improved survival and clinical outcomes, congenital heart disease (CHD) is an area of growing importance within the medical community. ...Given the complex nature of cardiac development, it is not surprising that multiple transcription factors and signaling molecule …
Due to improved survival and clinical outcomes, congenital heart disease (CHD) is an area of growing importance within the medical co …
Association of NFKB1, NKX2-5, GATA4 and RANKL Gene Polymorphisms with Sporadic Congenital Heart Disease in Greek Patients.
Aidinidou L, Chatzikyriakidou A, Giannopoulos A, Karpa V, Tzimou I, Aidinidou E, Fidani L. Aidinidou L, et al. Balkan J Med Genet. 2021 Jul 27;24(1):15-20. doi: 10.2478/bjmg-2021-0014. eCollection 2021 Jun. Balkan J Med Genet. 2021. PMID: 34447654 Free PMC article.
Congenital heart disease (CHD) is a group of structural defects of the heart and the great vessels, and one of the leading causes of death among infants and young adults. ...A total of 43 CHD patients and 100 healthy adults were included in the study. …
Congenital heart disease (CHD) is a group of structural defects of the heart and the great vessels, and one of the leading cau …
Prevalence and Spectrum of NKX2-5 Mutations Associated With Sporadic Adult-Onset Dilated Cardiomyopathy.
Xu JH, Gu JY, Guo YH, Zhang H, Qiu XB, Li RG, Shi HY, Liu H, Yang XX, Xu YJ, Qu XK, Yang YQ. Xu JH, et al. Int Heart J. 2017 Aug 3;58(4):521-529. doi: 10.1536/ihj.16-440. Epub 2017 Jul 10. Int Heart J. 2017. PMID: 28690296 Free article.
Recently, NKX2-5 mutations have been involved in the pathogenesis of familial DCM. ...A total of 300 unrelated healthy individuals used as controls were also genotyped for NKX2-5. The functional effect of the mutant NKX2-5 was investigate …
Recently, NKX2-5 mutations have been involved in the pathogenesis of familial DCM. ...A total of 300 unrelated healthy individ …
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.
Nielsen JB, Thorolfsdottir RB, Fritsche LG, Zhou W, Skov MW, Graham SE, Herron TJ, McCarthy S, Schmidt EM, Sveinbjornsson G, Surakka I, Mathis MR, Yamazaki M, Crawford RD, Gabrielsen ME, Skogholt AH, Holmen OL, Lin M, Wolford BN, Dey R, Dalen H, Sulem P, Chung JH, Backman JD, Arnar DO, Thorsteinsdottir U, Baras A, O'Dushlaine C, Holst AG, Wen X, Hornsby W, Dewey FE, Boehnke M, Kheterpal S, Mukherjee B, Lee S, Kang HM, Holm H, Kitzman J, Shavit JA, Jalife J, Brummett CM, Teslovich TM, Carey DJ, Gudbjartsson DF, Stefansson K, Abecasis GR, Hveem K, Willer CJ. Nielsen JB, et al. Nat Genet. 2018 Sep;50(9):1234-1239. doi: 10.1038/s41588-018-0171-3. Epub 2018 Jul 30. Nat Genet. 2018. PMID: 30061737 Free PMC article.
Many of the identified risk variants fall near genes where more deleterious mutations have been reported to cause serious heart defects in humans (GATA4, MYH6, NKX2-5, PITX2, TBX5)(1), or near genes important for striated muscle function and integrity (for ex …
Many of the identified risk variants fall near genes where more deleterious mutations have been reported to cause serious heart defec …
Furin, a transcriptional target of NKX2-5, has an essential role in heart development and function.
Dupays L, Towers N, Wood S, David A, Stuckey DJ, Mohun T. Dupays L, et al. PLoS One. 2019 Mar 6;14(3):e0212992. doi: 10.1371/journal.pone.0212992. eCollection 2019. PLoS One. 2019. PMID: 30840660 Free PMC article.
The homeodomain transcription factor NKX2-5 is known to be essential for both normal heart development and for heart function. ...Our results show that Furin mediate some aspects of Nkx2-5 function in the heart....
The homeodomain transcription factor NKX2-5 is known to be essential for both normal heart development and for heart …
Association of Maternal Diabetes Mellitus and Polymorphisms of the NKX2.5 Gene in Children with Congenital Heart Disease: A Single Centre-Based Case-Control Study.
Zhao M, Diao J, Huang P, Li J, Li Y, Yang Y, Luo L, Zhang S, Chen L, Wang T, Zhu P, Qin J. Zhao M, et al. J Diabetes Res. 2020 Sep 25;2020:3854630. doi: 10.1155/2020/3854630. eCollection 2020. J Diabetes Res. 2020. PMID: 33062711 Free PMC article.
We collected the mothers' information by questionnaire and detected children's NKX2.5 variants with a MassARRAY system. The interaction coefficient (gamma) was used to quantify the estimated gene-environment interactions. ...CONCLUSIONS: These results suggest …
We collected the mothers' information by questionnaire and detected children's NKX2.5 variants with a MassARRAY system. …
Variants in NKX2-5 and FLNC Cause Dilated Cardiomyopathy and Sudden Cardiac Death.
Sveinbjornsson G, Olafsdottir EF, Thorolfsdottir RB, Davidsson OB, Helgadottir A, Jonasdottir A, Jonasdottir A, Bjornsson E, Jensson BO, Arnadottir GA, Kristinsdottir H, Stephensen SS, Oskarsson G, Gudbjartsson T, Sigurdsson EL, Andersen K, Danielsen R, Arnar DO, Jonsdottir I, Thorsteinsdottir U, Sulem P, Thorgeirsson G, Gudbjartsson DF, Holm H, Stefansson K. Sveinbjornsson G, et al. Circ Genom Precis Med. 2018 Aug;11(8):e002151. doi: 10.1161/CIRCGEN.117.002151. Circ Genom Precis Med. 2018. PMID: 30354339 Free article.
Both variants associate with heart failure and sudden cardiac death. Additionally, p.Phe145Leu in NKX2-5 associates with high degree atrioventricular block and atrial septal defect ( P<1.410(-4)). The penetrance of serious heart disease among carrie …
Both variants associate with heart failure and sudden cardiac death. Additionally, p.Phe145Leu in NKX2-5 associates wit …
Point mutations in murine Nkx2-5 phenocopy human congenital heart disease and induce pathogenic Wnt signaling.
Furtado MB, Wilmanns JC, Chandran A, Perera J, Hon O, Biben C, Willow TJ, Nim HT, Kaur G, Simonds S, Wu Q, Willians D, Salimova E, Plachta N, Denegre JM, Murray SA, Fatkin D, Cowley M, Pearson JT, Kaye D, Ramialison M, Harvey RP, Rosenthal NA, Costa MW. Furtado MB, et al. JCI Insight. 2017 Mar 23;2(6):e88271. doi: 10.1172/jci.insight.88271. JCI Insight. 2017. PMID: 28352650 Free PMC article.
We further describe the molecular consequences of disrupting the transcriptional network regulated by Nkx2-5 in the heart and show that Nkx2-5-dependent perturbation of the Wnt signaling pathway promotes heart dysfunction through alterati …
We further describe the molecular consequences of disrupting the transcriptional network regulated by Nkx2-5 in the heart …
Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species.
Qian L, Wythe JD, Liu J, Cartry J, Vogler G, Mohapatra B, Otway RT, Huang Y, King IN, Maillet M, Zheng Y, Crawley T, Taghli-Lamallem O, Semsarian C, Dunwoodie S, Winlaw D, Harvey RP, Fatkin D, Towbin JA, Molkentin JD, Srivastava D, Ocorr K, Bruneau BG, Bodmer R. Qian L, et al. J Cell Biol. 2011 Jun 27;193(7):1181-96. doi: 10.1083/jcb.201006114. Epub 2011 Jun 20. J Cell Biol. 2011. PMID: 21690310 Free PMC article.
In exploring the mechanism of Nkx2-5 interaction with Cdc42, we demonstrated that mouse Cdc42 was a target of, and negatively regulated by miR-1, which itself was negatively regulated by Nkx2-5 in the mouse heart and by Tinman in the fly hear …
In exploring the mechanism of Nkx2-5 interaction with Cdc42, we demonstrated that mouse Cdc42 was a target of, and negatively …
Activation of the Nkx2.5-Calr-p53 signaling pathway by hyperglycemia induces cardiac remodeling and dysfunction in adult zebrafish.
Sun Y, Wang Q, Fang Y, Wu C, Lu G, Chen Z. Sun Y, et al. Dis Model Mech. 2017 Oct 1;10(10):1217-1227. doi: 10.1242/dmm.026781. Epub 2017 Aug 11. Dis Model Mech. 2017. PMID: 28801532 Free PMC article.
Significant upregulation of the expression of Nkx2.5 and its downstream targets calreticulin (Calr) and p53 was noted in the glucose-treated fish. ...In vitro experiments were performed using compound treatment and genetically via cell infection. Genetically, knocko …
Significant upregulation of the expression of Nkx2.5 and its downstream targets calreticulin (Calr) and p53 was noted in the g …
319 results