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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2005 1
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2012 3
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92 results

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Page 1
NLGN1 and NLGN2 in the prefrontal cortex: their role in memory consolidation and strengthening.
Katzman A, Alberini CM. Katzman A, et al. Curr Opin Neurobiol. 2018 Feb;48:122-130. doi: 10.1016/j.conb.2017.12.003. Epub 2017 Dec 23. Curr Opin Neurobiol. 2018. PMID: 29278843 Free PMC article. Review.
Here, we discuss recent findings revealing the roles of the excitatory and inhibitory synaptic proteins neuroligin 1 (NLGN1) and NLGN2 in the PFC in memory formation and modulation of memory strength. We propose that shifts in NLGN1 and NLGN2 expression in specific …
Here, we discuss recent findings revealing the roles of the excitatory and inhibitory synaptic proteins neuroligin 1 (NLGN1) and NLGN2 …
Functional Neuroligin-2-MDGA1 interactions differentially regulate synaptic GABAARs and cytosolic gephyrin aggregation.
Zeppillo T, Ali H, Ravichandran S, Ritter TC, Wenger S, López-Murcia FJ, Gideons E, Signorelli J, Schmeisser MJ, Wiltfang J, Rhee J, Brose N, Taschenberger H, Krueger-Burg D. Zeppillo T, et al. Commun Biol. 2024 Sep 17;7(1):1157. doi: 10.1038/s42003-024-06789-z. Commun Biol. 2024. PMID: 39284869 Free PMC article.
Neuroligin-2 (Nlgn2) is a key synaptic adhesion protein at virtually all GABAergic synapses, which recruits GABA(A)Rs by promoting assembly of the postsynaptic gephyrin scaffold. ...Here we investigated how Nlgn2 function in hippocampal area CA1 is modulated by two …
Neuroligin-2 (Nlgn2) is a key synaptic adhesion protein at virtually all GABAergic synapses, which recruits GABA(A)Rs by promoting as …
Prognostic role of NLGN2 and PTGDS in medulloblastoma based on gene expression omnibus.
Ren Z, Gao M, Jiang W. Ren Z, et al. Am J Transl Res. 2022 Jun 15;14(6):3769-3782. eCollection 2022. Am J Transl Res. 2022. PMID: 35836891 Free PMC article.
Children with MB (n=55) diagnosed in Affiliated Ezhou Central Hospital were enrolled and assigned to the patient group, and healthy children (n=30) who received physical examination in our hospital during the same time period were assigned to the control group. The two groups wer …
Children with MB (n=55) diagnosed in Affiliated Ezhou Central Hospital were enrolled and assigned to the patient group, and healthy children …
Identifying therapeutic target genes for migraine by systematic druggable genome-wide Mendelian randomization.
Zhang C, He Y, Liu L. Zhang C, et al. J Headache Pain. 2024 Jun 12;25(1):100. doi: 10.1186/s10194-024-01805-3. J Headache Pain. 2024. PMID: 38867170 Free PMC article.
RESULTS: We identified 21 druggable genes significantly associated with migraine (BRPF3, CBFB, CDK4, CHD4, DDIT4, EP300, EPHA5, FGFRL1, FXN, HMGCR, HVCN1, KCNK5, MRGPRE, NLGN2, NR1D1, PLXNB1, TGFB1, TGFB3, THRA, TLN1 and TP53), two of which were significant in both blood a …
RESULTS: We identified 21 druggable genes significantly associated with migraine (BRPF3, CBFB, CDK4, CHD4, DDIT4, EP300, EPHA5, FGFRL1, FXN, …
Large-scale discovery of novel neurodevelopmental disorder-related genes through a unified analysis of single-nucleotide and copy number variants.
Hamanaka K, Miyake N, Mizuguchi T, Miyatake S, Uchiyama Y, Tsuchida N, Sekiguchi F, Mitsuhashi S, Tsurusaki Y, Nakashima M, Saitsu H, Yamada K, Sakamoto M, Fukuda H, Ohori S, Saida K, Itai T, Azuma Y, Koshimizu E, Fujita A, Erturk B, Hiraki Y, Ch'ng GS, Kato M, Okamoto N, Takata A, Matsumoto N. Hamanaka K, et al. Genome Med. 2022 Apr 26;14(1):40. doi: 10.1186/s13073-022-01042-w. Genome Med. 2022. PMID: 35468861 Free PMC article.
Quantifying the overall similarity using deep learning, we identified 11 high-confidence (> 90% true-positive probabilities) candidate genes: HDAC2, SUPT16H, HECTD4, CHD5, XPO1, GSK3B, NLGN2, ADGRB1, CTR9, BRD3, and MARK2. CONCLUSIONS: We identified dozens of new candid …
Quantifying the overall similarity using deep learning, we identified 11 high-confidence (> 90% true-positive probabilities) candidate ge …
Chronic stress induces depression through MDGA1-Neuroligin2 mediated suppression of inhibitory synapses in the lateral habenula.
Wang X, Wei H, Hu Z, Jiang J, Dong X, Zhu J, Chen H, Brose N, Lipstein N, Xu T, Connor SA, Ma D, Xie Y. Wang X, et al. Theranostics. 2025 Jan 2;15(5):1842-1863. doi: 10.7150/thno.104282. eCollection 2025. Theranostics. 2025. PMID: 39897557 Free PMC article.
Introduction of the Nlgn2 variant incapable of binding MDGA1 similarly enhanced inhibitory transmission and increased GABAergic synapse density in the LHb. ...Conclusions: Our findings suggests that MDGA1-mediated suppression of Nlgn2 facilitates depression onset th …
Introduction of the Nlgn2 variant incapable of binding MDGA1 similarly enhanced inhibitory transmission and increased GABAergic synap …
Synaptic deficits in iPSC-derived cortical interneurons in schizophrenia are mediated by NLGN2 and rescued by N-acetylcysteine.
Kathuria A, Lopez-Lengowski K, Watmuff B, McPhie D, Cohen BM, Karmacharya R. Kathuria A, et al. Transl Psychiatry. 2019 Nov 28;9(1):321. doi: 10.1038/s41398-019-0660-x. Transl Psychiatry. 2019. PMID: 31780643 Free PMC article.
NLGN2 overexpression in schizophrenia neurons rescued synaptic puncta deficits while NLGN2 knockdown in healthy neurons resulted in reduced synaptic puncta density. ...The antioxidant N-acetylcysteine increased the nuclear area in schizophrenia interneurons, increas …
NLGN2 overexpression in schizophrenia neurons rescued synaptic puncta deficits while NLGN2 knockdown in healthy neurons result …
Alogliptin Reduces Oxidative Stress in Cardiomyocytes and Ameliorates Diabetic Cardiomyopathy via the AURKB/NLGN2 Signaling.
Jiao LJ, Zhou J, Wang J, Zhao SN, Zhao ZS, Wang Q, Xie YN, Jiao W. Jiao LJ, et al. Kaohsiung J Med Sci. 2025 Dec 22:e70149. doi: 10.1002/kjm2.70149. Online ahead of print. Kaohsiung J Med Sci. 2025. PMID: 41428503 Free article.
Bioinformatics analysis revealed that the target of alogliptin was AURKB, and the downstream target of AURKB was NLGN2. AURKB and NLGN2 levels were reduced in the heart tissues of streptozotocin-induced mice. Combined knockdown of AURKB and NLGN2 inhibited th …
Bioinformatics analysis revealed that the target of alogliptin was AURKB, and the downstream target of AURKB was NLGN2. AURKB and …
92 results