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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 1
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2012 9
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161 results

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Page 1
Neuron-secreted NLGN3 ameliorates ischemic brain injury via activating Galphai1/3-Akt signaling.
Chen ZG, Shi X, Zhang XX, Yang FF, Li KR, Fang Q, Cao C, Chen XH, Peng Y. Chen ZG, et al. Cell Death Dis. 2023 Oct 25;14(10):700. doi: 10.1038/s41419-023-06219-8. Cell Death Dis. 2023. PMID: 37880221 Free PMC article.
Akt activation was required for NLGN3-induced neuroprotection. Galphai1/3 mediated NLGN3-induced downstream signaling activation. NLGN3-induced Akt-S6K1 activation was largely inhibited by Galphai1/3 silencing or knockout. ...
Akt activation was required for NLGN3-induced neuroprotection. Galphai1/3 mediated NLGN3-induced downstream signaling activati …
Stabilization of KPNB1 by deubiquitinase USP7 promotes glioblastoma progression through the YBX1-NLGN3 axis.
Li J, Zhang B, Feng Z, An D, Zhou Z, Wan C, Hu Y, Sun Y, Wang Y, Liu X, Wei W, Yang X, Meng J, Che M, Sheng Y, Wu B, Wen L, Huang F, Li Y, Yang K. Li J, et al. J Exp Clin Cancer Res. 2024 Jan 23;43(1):28. doi: 10.1186/s13046-024-02954-8. J Exp Clin Cancer Res. 2024. PMID: 38254206 Free PMC article.
In addition, we found that KPNB1 could regulate the downstream expression of Neuroligin-3 (NLGN3) by mediating the nuclear import of transcription factor YBX1, which could bind to the NLGN3 promoter. ...CONCLUSION: This study identified a novel and targetable USP7/K …
In addition, we found that KPNB1 could regulate the downstream expression of Neuroligin-3 (NLGN3) by mediating the nuclear import of …
Regulation of NLGN3 and the Synaptic Rho-GEF Signaling Pathway by CDK5.
Jeong J, Han W, Hong E, Pandey S, Li Y, Lu W, Roche KW. Jeong J, et al. J Neurosci. 2023 Nov 1;43(44):7264-7275. doi: 10.1523/JNEUROSCI.2309-22.2023. Epub 2023 Sep 12. J Neurosci. 2023. PMID: 37699715 Free PMC article.
Thus, we characterized NLGN3 as a novel Cdk5 substrate and revealed the functional consequences of NLGN3 S725 phosphorylation in neurons. ...We demonstrate that NLGN3 S725 is a Cdk5 phosphorylation site, and reveal that the site is important for NLGN3
Thus, we characterized NLGN3 as a novel Cdk5 substrate and revealed the functional consequences of NLGN3 S725 phosphorylation …
Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.
Jamain S, Quach H, Betancur C, Råstam M, Colineaux C, Gillberg IC, Soderstrom H, Giros B, Leboyer M, Gillberg C, Bourgeron T; Paris Autism Research International Sibpair Study. Jamain S, et al. Nat Genet. 2003 May;34(1):27-9. doi: 10.1038/ng1136. Nat Genet. 2003. PMID: 12669065 Free PMC article.
Here we report mutations in two X-linked genes encoding neuroligins NLGN3 and NLGN4 in siblings with autism-spectrum disorders. These mutations affect cell-adhesion molecules localized at the synapse and suggest that a defect of synaptogenesis may predispose to autism....
Here we report mutations in two X-linked genes encoding neuroligins NLGN3 and NLGN4 in siblings with autism-spectrum disorders. These …
Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion.
Venkatesh HS, Johung TB, Caretti V, Noll A, Tang Y, Nagaraja S, Gibson EM, Mount CW, Polepalli J, Mitra SS, Woo PJ, Malenka RC, Vogel H, Bredel M, Mallick P, Monje M. Venkatesh HS, et al. Cell. 2015 May 7;161(4):803-16. doi: 10.1016/j.cell.2015.04.012. Epub 2015 Apr 23. Cell. 2015. PMID: 25913192 Free PMC article.
NLGN3 induced PI3K-mTOR pathway activity and feedforward expression of NLGN3 in glioma cells. NLGN3 expression levels in human HGG negatively correlated with patient overall survival. ...
NLGN3 induced PI3K-mTOR pathway activity and feedforward expression of NLGN3 in glioma cells. NLGN3 expression levels i
Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma.
Venkatesh HS, Tam LT, Woo PJ, Lennon J, Nagaraja S, Gillespie SM, Ni J, Duveau DY, Morris PJ, Zhao JJ, Thomas CJ, Monje M. Venkatesh HS, et al. Nature. 2017 Sep 28;549(7673):533-537. doi: 10.1038/nature24014. Epub 2017 Sep 20. Nature. 2017. PMID: 28959975 Free PMC article.
An important mechanism that mediates this neural regulation of brain cancer is activity-dependent cleavage and secretion of the synaptic adhesion molecule neuroligin-3 (NLGN3), which promotes glioma proliferation through the PI3K-mTOR pathway. However, the necessity of …
An important mechanism that mediates this neural regulation of brain cancer is activity-dependent cleavage and secretion of the synaptic adh …
NLGN3 promotes neuroblastoma cell proliferation and growth through activating PI3K/AKT pathway.
Li Z, Gao W, Fei Y, Gao P, Xie Q, Xie J, Xu Z. Li Z, et al. Eur J Pharmacol. 2019 Aug 15;857:172423. doi: 10.1016/j.ejphar.2019.172423. Epub 2019 May 28. Eur J Pharmacol. 2019. PMID: 31150649
Neuroblastoma is the most common extracranial solid tumor of childhood, previous studies show synaptic protein neuroligin-3 (NLGN3) promotes glioma proliferation and growth, However, no investigation about the role of NLGN3 in neuroblastoma was reported. Here, we fo …
Neuroblastoma is the most common extracranial solid tumor of childhood, previous studies show synaptic protein neuroligin-3 (NLGN3) p …
Autism-linked NLGN3 is a key regulator of gonadotropin-releasing hormone deficiency.
Oleari R, Lettieri A, Manzini S, Paganoni A, André V, Grazioli P, Busnelli M, Duminuco P, Vitobello A, Philippe C, Bizaoui V, Storr HL, Amoruso F, Memi F, Vezzoli V, Massa V, Scheiffele P, Howard SR, Cariboni A. Oleari R, et al. Dis Model Mech. 2023 Mar 1;16(3):dmm049996. doi: 10.1242/dmm.049996. Epub 2023 Mar 28. Dis Model Mech. 2023. PMID: 36810932 Free PMC article.
Among differentially expressed and filtered transcripts, we found loss-of-function (LoF) variants of the autism-linked neuroligin 3 (NLGN3) gene in two unrelated patients co-presenting with GD and neurodevelopmental traits. We demonstrated that NLGN3 is upregulated …
Among differentially expressed and filtered transcripts, we found loss-of-function (LoF) variants of the autism-linked neuroligin 3 (NLGN
Autism spectrum disorder: neuropathology and animal models.
Varghese M, Keshav N, Jacot-Descombes S, Warda T, Wicinski B, Dickstein DL, Harony-Nicolas H, De Rubeis S, Drapeau E, Buxbaum JD, Hof PR. Varghese M, et al. Acta Neuropathol. 2017 Oct;134(4):537-566. doi: 10.1007/s00401-017-1736-4. Epub 2017 Jun 5. Acta Neuropathol. 2017. PMID: 28584888 Free PMC article. Review.
Genetically modified models include those based on well-studied monogenic ASD genes (NLGN3, NLGN4, NRXN1, CNTNAP2, SHANK3, MECP2, FMR1, TSC1/2), emerging risk genes (CHD8, SCN2A, SYNGAP1, ARID1B, GRIN2B, DSCAM, TBR1), and copy number variants (15q11-q13 deletion, 15q13.3 m …
Genetically modified models include those based on well-studied monogenic ASD genes (NLGN3, NLGN4, NRXN1, CNTNAP2, SHANK3, MECP2, FMR …
Evidence for a Contribution of the Nlgn3/Cyfip1/Fmr1 Pathway in the Pathophysiology of Autism Spectrum Disorders.
Sledziowska M, Galloway J, Baudouin SJ. Sledziowska M, et al. Neuroscience. 2020 Oct 1;445:31-41. doi: 10.1016/j.neuroscience.2019.10.011. Epub 2019 Nov 6. Neuroscience. 2020. PMID: 31705895 Review.
Many of these genes were found to play a role in neuronal and synaptic development and function. Among these genes are FMR1, CYFIP1 and NLGN3, all present at the synapse and reliably linked to ASD. In this review, we evaluate the evidence for the contribution of these gene …
Many of these genes were found to play a role in neuronal and synaptic development and function. Among these genes are FMR1, CYFIP1 and N
161 results