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118 results

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Page 1
NLGN4X TCR transgenic T cells to treat gliomas.
Krämer C, Kilian M, Chih YC, Kourtesakis A, Hoffmann DC, Boschert T, Koopmann P, Sanghvi K, De Roia A, Jung S, Jähne K, Day B, Shultz LD, Ratliff M, Harbottle R, Green EW, Will R, Wick W, Platten M, Bunse L. Krämer C, et al. Neuro Oncol. 2024 Feb 2;26(2):266-278. doi: 10.1093/neuonc/noad172. Neuro Oncol. 2024. PMID: 37715782 Free PMC article.
METHODS: T cell receptor (TCR) discovery was performed using droplet-based single-cell TCR sequencing of NLGN4X-tetramer-sorted T cells postvaccination. The identified TCR was delivered to Jurkat T cells and primary human T cells (NLGN4X-TCR-T). Functional profiling …
METHODS: T cell receptor (TCR) discovery was performed using droplet-based single-cell TCR sequencing of NLGN4X-tetramer-sorted T cel …
Phosphorylation of NLGN4X Regulates Spinogenesis and Synaptic Function.
Lehr AW, Nguyen TA, Han W, Hong E, Badger JD 2nd, Lu W, Roche KW. Lehr AW, et al. eNeuro. 2025 Mar 14;12(3):ENEURO.0278-23.2025. doi: 10.1523/ENEURO.0278-23.2025. Print 2025 Mar. eNeuro. 2025. PMID: 40032531 Free PMC article.
In this report, we characterize a conserved phosphorylation site, serine 712, on NLGN4X and 4Y. Despite serine 712 being located in a highly conserved region between NLGN4X and 4Y, we observed kinase specificity. PKA exclusively phosphorylates NLGN4X S712, wh …
In this report, we characterize a conserved phosphorylation site, serine 712, on NLGN4X and 4Y. Despite serine 712 being located in a …
A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y.
Nguyen TA, Wu K, Pandey S, Lehr AW, Li Y, Bemben MA, Badger JD 2nd, Lauzon JL, Wang T, Zaghloul KA, Thurm A, Jain M, Lu W, Roche KW. Nguyen TA, et al. Neuron. 2020 Jun 3;106(5):759-768.e7. doi: 10.1016/j.neuron.2020.03.008. Epub 2020 Apr 2. Neuron. 2020. PMID: 32243781 Free PMC article.
Many mutations on X-linked cell adhesion molecule NLGN4X result in ASD or intellectual disability. NLGN4X is part of an X-Y pair, with NLGN4Y sharing 97% sequence homology. ...We show that NLGN4Y cannot compensate for the functional deficits observed in ASD-associat …
Many mutations on X-linked cell adhesion molecule NLGN4X result in ASD or intellectual disability. NLGN4X is part of an X-Y pa …
Analysis of the human kidney transcriptome and plasma proteome identifies markers of proximal tubule maladaptation to injury.
Wen Y, Su E, Xu L, Menez S, Moledina DG, Obeid W, Palevsky PM, Mansour SG, Devarajan P, Cantley LG, Cahan P, Parikh CR; Kidney Precision Medicine Project; Translational Investigation of Biomarker Endpoint of Acute Kidney Injury. Wen Y, et al. Sci Transl Med. 2023 Dec 13;15(726):eade7287. doi: 10.1126/scitranslmed.ade7287. Epub 2023 Dec 13. Sci Transl Med. 2023. PMID: 38091407 Free PMC article.
After cardiac surgery, both cohorts of patients had increased transforming growth factor-beta2 (TGFB2), collagen type XXIII-alpha1 (COL23A1), and X-linked neuroligin 4 (NLGN4X) and had decreased plasminogen (PLG), ectonucleotide pyrophosphatase/phosphodiesterase 6 (ENPP6), …
After cardiac surgery, both cohorts of patients had increased transforming growth factor-beta2 (TGFB2), collagen type XXIII-alpha1 (COL23A1) …
Late stage melanoma is hallmarked by low NLGN4X expression leading to HIF1A accumulation.
Schörghofer D, Vock L, Mirea MA, Eckel O, Gschwendtner A, Neesen J, Richtig E, Hengstschläger M, Mikula M. Schörghofer D, et al. Br J Cancer. 2024 Aug;131(3):468-480. doi: 10.1038/s41416-024-02758-9. Epub 2024 Jun 20. Br J Cancer. 2024. PMID: 38902533 Free PMC article.
Here we studied the postsynaptic cell adhesion molecule Neuroligin 4X (NLGN4X) and investigated its role in melanoma progression. METHODS: We analysed histologic samples to assess the expression and predictive value of NLGN4X in human melanoma. ...CONCLUSION: In vie …
Here we studied the postsynaptic cell adhesion molecule Neuroligin 4X (NLGN4X) and investigated its role in melanoma progression. MET …
Pathogenic paternally inherited NLGN4X deletion in a female with autism spectrum disorder: Clinical, cytogenetic, and molecular characterization.
Kopp N, Amarillo I, Martinez-Agosto J, Quintero-Rivera F. Kopp N, et al. Am J Med Genet A. 2021 Mar;185(3):894-900. doi: 10.1002/ajmg.a.62025. Epub 2020 Dec 24. Am J Med Genet A. 2021. PMID: 33369065
Our report describes the first example of a paternally inherited NLGN4X microdeletion as the genetic etiology of ASD in a female proband, and the psychiatric phenotypes in the father. It also provides further evidence that NLGN4X is sensitive to dosage changes in fe …
Our report describes the first example of a paternally inherited NLGN4X microdeletion as the genetic etiology of ASD in a female prob …
Neuroligins and Neurodevelopmental Disorders: X-Linked Genetics.
Nguyen TA, Lehr AW, Roche KW. Nguyen TA, et al. Front Synaptic Neurosci. 2020 Aug 11;12:33. doi: 10.3389/fnsyn.2020.00033. eCollection 2020. Front Synaptic Neurosci. 2020. PMID: 32848696 Free PMC article. Review.
In addition, there is a less studied human neuroligin on the Y chromosome, NLGN4Y, which forms an X-Y pair with NLGN4X. We will discuss recent findings of these neuroligin isoforms regarding function at the synapse in both rodent models and human-derived differentiated neu …
In addition, there is a less studied human neuroligin on the Y chromosome, NLGN4Y, which forms an X-Y pair with NLGN4X. We will discu …
Novel human sex-typing strategies based on the autism candidate gene NLGN4X and its male-specific gametologue NLGN4Y.
Maxeiner S, Sester M, Krasteva-Christ G. Maxeiner S, et al. Biol Sex Differ. 2019 Dec 18;10(1):62. doi: 10.1186/s13293-019-0279-x. Biol Sex Differ. 2019. PMID: 31852540 Free PMC article.
We hypothesize that sex-typing in humans is also possible based on the genes NLGN4X and NLGN4Y, which represent X and Y chromosome-specific copies of a common ancestral neuroligin-4 orthologue. ...CONCLUSIONS: These results indicate that the detection of human NLGN4X …
We hypothesize that sex-typing in humans is also possible based on the genes NLGN4X and NLGN4Y, which represent X and Y chromosome-sp …
The functional genetic link of NLGN4X knockdown and neurodevelopment in neural stem cells.
Shi L, Chang X, Zhang P, Coba MP, Lu W, Wang K. Shi L, et al. Hum Mol Genet. 2013 Sep 15;22(18):3749-60. doi: 10.1093/hmg/ddt226. Epub 2013 May 24. Hum Mol Genet. 2013. PMID: 23710042 Free PMC article.
However, it is unclear how mutations in NLGN4X result in neurodevelopmental defects. Here, we used neural stem cells (NSCs) as in vitro models to explore the impacts of NLGN4X knockdown on neurodevelopment. Using two shRNAmir-based vectors targeting NLGN4X an …
However, it is unclear how mutations in NLGN4X result in neurodevelopmental defects. Here, we used neural stem cells (NSCs) as in vit …
118 results