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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 1
2003 2
2004 4
2005 4
2006 5
2007 5
2008 6
2009 8
2010 5
2011 3
2012 9
2013 10
2014 3
2015 5
2016 7
2017 6
2018 5
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2020 11
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2024 2

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111 results

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Page 1
NLGN4X TCR transgenic T cells to treat gliomas.
Krämer C, Kilian M, Chih YC, Kourtesakis A, Hoffmann DC, Boschert T, Koopmann P, Sanghvi K, De Roia A, Jung S, Jähne K, Day B, Shultz LD, Ratliff M, Harbottle R, Green EW, Will R, Wick W, Platten M, Bunse L. Krämer C, et al. Neuro Oncol. 2024 Feb 2;26(2):266-278. doi: 10.1093/neuonc/noad172. Neuro Oncol. 2024. PMID: 37715782 Free PMC article.
Functional profiling of NLGN4X-TCR-T was performed by flow cytometry and cytotoxicity assays. ...CONCLUSION: NLGN4X-TCR-T demonstrate efficacy in a preclinical glioblastoma model. ...
Functional profiling of NLGN4X-TCR-T was performed by flow cytometry and cytotoxicity assays. ...CONCLUSION: NLGN4X-TCR-T demo …
A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y.
Nguyen TA, Wu K, Pandey S, Lehr AW, Li Y, Bemben MA, Badger JD 2nd, Lauzon JL, Wang T, Zaghloul KA, Thurm A, Jain M, Lu W, Roche KW. Nguyen TA, et al. Neuron. 2020 Jun 3;106(5):759-768.e7. doi: 10.1016/j.neuron.2020.03.008. Epub 2020 Apr 2. Neuron. 2020. PMID: 32243781 Free PMC article.
Autism spectrum disorder (ASD) is more prevalent in males; however, the etiology for this sex bias is not well understood. Many mutations on X-linked cell adhesion molecule NLGN4X result in ASD or intellectual disability. NLGN4X is part of an X-Y pair, with NLGN4Y s …
Autism spectrum disorder (ASD) is more prevalent in males; however, the etiology for this sex bias is not well understood. Many mutations on …
Pathogenic paternally inherited NLGN4X deletion in a female with autism spectrum disorder: Clinical, cytogenetic, and molecular characterization.
Kopp N, Amarillo I, Martinez-Agosto J, Quintero-Rivera F. Kopp N, et al. Am J Med Genet A. 2021 Mar;185(3):894-900. doi: 10.1002/ajmg.a.62025. Epub 2020 Dec 24. Am J Med Genet A. 2021. PMID: 33369065
Our report describes the first example of a paternally inherited NLGN4X microdeletion as the genetic etiology of ASD in a female proband, and the psychiatric phenotypes in the father. It also provides further evidence that NLGN4X is sensitive to dosage changes in fe …
Our report describes the first example of a paternally inherited NLGN4X microdeletion as the genetic etiology of ASD in a female prob …
The functional genetic link of NLGN4X knockdown and neurodevelopment in neural stem cells.
Shi L, Chang X, Zhang P, Coba MP, Lu W, Wang K. Shi L, et al. Hum Mol Genet. 2013 Sep 15;22(18):3749-60. doi: 10.1093/hmg/ddt226. Epub 2013 May 24. Hum Mol Genet. 2013. PMID: 23710042 Free PMC article.
However, it is unclear how mutations in NLGN4X result in neurodevelopmental defects. Here, we used neural stem cells (NSCs) as in vitro models to explore the impacts of NLGN4X knockdown on neurodevelopment. Using two shRNAmir-based vectors targeting NLGN4X an …
However, it is unclear how mutations in NLGN4X result in neurodevelopmental defects. Here, we used neural stem cells (NSCs) as in vit …
Variations analysis of NLGN3 and NLGN4X gene in Chinese autism patients.
Xu X, Xiong Z, Zhang L, Liu Y, Lu L, Peng Y, Guo H, Zhao J, Xia K, Hu Z. Xu X, et al. Mol Biol Rep. 2014 Jun;41(6):4133-40. doi: 10.1007/s11033-014-3284-5. Epub 2014 Feb 26. Mol Biol Rep. 2014. PMID: 24570023
In this study, four missense variations [p.G426S (NLGN3), p.G84R (NLGN4X), p.Q162 K (NLGN4X) and p.A283T (NLGN4X)] in four different unrelated patients have been identified by PCR and direct sequencing. ...Our data provided a further evidence for the involvem …
In this study, four missense variations [p.G426S (NLGN3), p.G84R (NLGN4X), p.Q162 K (NLGN4X) and p.A283T (NLGN4X)] in f …
Novel human sex-typing strategies based on the autism candidate gene NLGN4X and its male-specific gametologue NLGN4Y.
Maxeiner S, Sester M, Krasteva-Christ G. Maxeiner S, et al. Biol Sex Differ. 2019 Dec 18;10(1):62. doi: 10.1186/s13293-019-0279-x. Biol Sex Differ. 2019. PMID: 31852540 Free PMC article.
We hypothesize that sex-typing in humans is also possible based on the genes NLGN4X and NLGN4Y, which represent X and Y chromosome-specific copies of a common ancestral neuroligin-4 orthologue. ...CONCLUSIONS: These results indicate that the detection of human NLGN4X …
We hypothesize that sex-typing in humans is also possible based on the genes NLGN4X and NLGN4Y, which represent X and Y chromosome-sp …
Analysis of the SNP rs3747333 and rs3747334 in NLGN4X gene in autism spectrum disorder: a meta-analysis.
Sun H, Yang Y, Zhang L, Wu H, Zhang H, Li H. Sun H, et al. Ann Gen Psychiatry. 2019 May 21;18:6. doi: 10.1186/s12991-019-0227-5. eCollection 2019. Ann Gen Psychiatry. 2019. PMID: 31139237 Free PMC article.
BACKGROUND: The SNP rs3747333 and rs3747334 in Neuroligin 4X (NLGN4X) gene have been demonstrated to be associated with the susceptibility to Autism spectrum disorder (ASDs; MIM 209850), but the results are inconsistent. ...CONCLUSIONS: In conclusion, our meta-analysis sug …
BACKGROUND: The SNP rs3747333 and rs3747334 in Neuroligin 4X (NLGN4X) gene have been demonstrated to be associated with the susceptib …
Late stage melanoma is hallmarked by low NLGN4X expression leading to HIF1A accumulation.
Schörghofer D, Vock L, Mirea MA, Eckel O, Gschwendtner A, Neesen J, Richtig E, Hengstschläger M, Mikula M. Schörghofer D, et al. Br J Cancer. 2024 Aug;131(3):468-480. doi: 10.1038/s41416-024-02758-9. Epub 2024 Jun 20. Br J Cancer. 2024. PMID: 38902533 Free PMC article.
Here we studied the postsynaptic cell adhesion molecule Neuroligin 4X (NLGN4X) and investigated its role in melanoma progression. METHODS: We analysed histologic samples to assess the expression and predictive value of NLGN4X in human melanoma. ...CONCLUSION: In vie …
Here we studied the postsynaptic cell adhesion molecule Neuroligin 4X (NLGN4X) and investigated its role in melanoma progression. MET …
111 results