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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 1
2004 2
2005 1
2006 1
2007 1
2008 2
2009 6
2010 7
2011 2
2012 3
2013 2
2014 1
2015 6
2016 4
2017 5
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2023 11
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92 results

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Page 1
Prevention of MK-801-induced amnestic effect with combined activation of 5-HT1A and muscarinic receptors in mice.
Cieślik P, Rafało-Ulińska A, Wierońska JM. Cieślik P, et al. Pharmacol Biochem Behav. 2024 May;238:173749. doi: 10.1016/j.pbb.2024.173749. Epub 2024 Mar 9. Pharmacol Biochem Behav. 2024. PMID: 38462045
Western blotting was used to study the expressions of 5-HT(1A) receptors and the level of GAD(65) in the frontal cortices (FCs) and hippocampi of the animals. RESULTS: F15599 prevented the amnestic effect induced by MK-801 in the MWM at a dose of 0.1 mg/kg. ...No effects o …
Western blotting was used to study the expressions of 5-HT(1A) receptors and the level of GAD(65) in the frontal cortices (FCs) and hippocam …
Altered brain serotonin 5-HT1A receptor expression and function in juvenile Fmr1 knockout mice.
Saraf TS, Chen Y, Tyagi R, Canal CE. Saraf TS, et al. Neuropharmacology. 2024 Mar 1;245:109774. doi: 10.1016/j.neuropharm.2023.109774. Epub 2023 Nov 3. Neuropharmacology. 2024. PMID: 37923121
Consistent with these results, juvenile Fmr1 knockout mice showed reduced behavioral responses elicited by the 5-HT(1A)R agonist (R)-8-OH-DPAT, effects blocked by the selective 5-HT(1A)R antagonist, WAY-100635. Also, treatment with the selective 5-HT(1A)R agonist, NLX-1
Consistent with these results, juvenile Fmr1 knockout mice showed reduced behavioral responses elicited by the 5-HT(1A)R agonist (R)-8-OH-DP …
Multimodal imaging study of the 5-HT(1A) receptor biased agonist, NLX-112, in a model of L-DOPA-induced dyskinesia.
Chaib S, Vidal B, Bouillot C, Depoortere R, Newman-Tancredi A, Zimmer L, Levigoureux E. Chaib S, et al. Neuroimage Clin. 2023;39:103497. doi: 10.1016/j.nicl.2023.103497. Epub 2023 Aug 15. Neuroimage Clin. 2023. PMID: 37632990 Free PMC article.
Serotonergic neurons are involved in LID etiology and previous pre-clinical studies have shown that NLX-112, a 5-HT(1A) biased agonist, has robust antidyskinetic effects. ...In addition, NLX-112 also rescues L-DOPA-induced deficits in cortical activati …
Serotonergic neurons are involved in LID etiology and previous pre-clinical studies have shown that NLX-112, a 5-HT(1A) biased …
Gα Protein Signaling Bias at Serotonin 1A Receptor.
Alabdali R, Franchini L, Orlandi C. Alabdali R, et al. Mol Pharmacol. 2023 Nov;104(5):230-238. doi: 10.1124/molpharm.123.000722. Epub 2023 Aug 11. Mol Pharmacol. 2023. PMID: 37567783 Free PMC article.
The Serotonin 1A (5-HT1A) Receptor as a Pharmacological Target in Depression.
Smith ALW, Harmer CJ, Cowen PJ, Murphy SE. Smith ALW, et al. CNS Drugs. 2023 Jul;37(7):571-585. doi: 10.1007/s40263-023-01014-7. Epub 2023 Jun 29. CNS Drugs. 2023. PMID: 37386328 Review.
The development of 5-HT(1A) 'biased agonism', using compounds such as NLX-101, offers the opportunity to further elucidate the roles of pre- and post-synaptic 5-HT(1A) receptors. ...
The development of 5-HT(1A) 'biased agonism', using compounds such as NLX-101, offers the opportunity to further elucidate the …
The 5-HT(1A) receptor biased agonists, NLX-204 and NLX-101, display ketamine-like RAAD and anti-TRD activities in rat CMS models.
Papp M, Gruca P, Lason M, Litwa E, Newman-Tancredi A, Depoortère R. Papp M, et al. Psychopharmacology (Berl). 2023 Nov;240(11):2419-2433. doi: 10.1007/s00213-023-06389-5. Epub 2023 Jun 13. Psychopharmacology (Berl). 2023. PMID: 37310446 Free PMC article.
OBJECTIVES: NLX-101 and NLX-204 are highly selective serotonin 5-HT(1A) 'biased' agonists, displaying potent and efficacious antidepressant-like activity upon acute administration in models such as the forced swim test. ...These effects persisted for 3 …
OBJECTIVES: NLX-101 and NLX-204 are highly selective serotonin 5-HT(1A) 'biased' agonists, displaying potent and …
Models of Affective Illness: Chronic Mild Stress in the Rat.
Papp M, Willner P. Papp M, et al. Curr Protoc. 2023 Mar;3(3):e712. doi: 10.1002/cpz1.712. Curr Protoc. 2023. PMID: 36892313
For example, the CMS-induced deficits can be reversed by acute or sub-chronic application of treatments that act rapidly in depressed patients, such as deep brain stimulation (DBS), ketamine, and scopolamine, as well as several compounds that have yet to be tested in humans but h …
For example, the CMS-induced deficits can be reversed by acute or sub-chronic application of treatments that act rapidly in depressed patien …
NLX-101, a 5-HT(1A) receptor-biased agonist, improves pattern separation and stimulates neuroplasticity in aged rats.
Aguiar RP, Soares LM, Varney M, Newman-Tancredi A A, Milani H, Prickaerts J, de Oliveira RMW. Aguiar RP, et al. Neurobiol Aging. 2023 Apr;124:52-59. doi: 10.1016/j.neurobiolaging.2022.12.013. Epub 2022 Dec 31. Neurobiol Aging. 2023. PMID: 36739621
Here, we investigated the effects of acute and repeated treatment with NLX-101 (F15599), a postsynaptic 5-HT(1A) receptor-biased agonist, and F13714, a presynaptic 5-HT(1A) receptor-biased agonist on spatial object pattern separation (OPS) in aged (22-24 mont …
Here, we investigated the effects of acute and repeated treatment with NLX-101 (F15599), a postsynaptic 5-HT(1A) recept …
92 results