Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 1
2004 2
2005 1
2006 1
2007 1
2008 2
2009 6
2010 7
2011 2
2012 3
2013 2
2014 1
2015 6
2016 4
2017 5
2018 8
2019 11
2020 10
2021 14
2022 13
2023 11
2024 10
2025 6

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

104 results

Results by year

Filters applied: . Clear all
Page 1
Functional MRI Analysis of Brain Activity in Rats With Diabetic Bladder Dysfunction.
Li M, Chen X, Ye J, Sun Y, Hou C, Cao N, Thompson GJ, Gu B. Li M, et al. CNS Neurosci Ther. 2025 Jun;31(6):e70466. doi: 10.1111/cns.70466. CNS Neurosci Ther. 2025. PMID: 40458921 Free PMC article.
Furthermore, as prior research has suggested that NLX-112, a 5-HT(1A) receptor agonist, may alleviate DBD, we sought to explore its effects on brain activity in DBD rats. ...During micturition, DM rats showed increased activation in the thalamus, primary motor corte …
Furthermore, as prior research has suggested that NLX-112, a 5-HT(1A) receptor agonist, may alleviate DBD, we sought to explor …
Rescue of respiratory and cognitive impairments in Rett Syndrome mice using NLX-101, a selective 5-HT(1A) receptor biased agonist.
Monteiro-Fernandes D, Charles I, Guerreiro S, Cunha-Garcia D, Pereira-Sousa J, Oliveira S, Teixeira-Castro A, Varney MA, Kleven MS, Newman-Tancredi A, P Sheikh Abdala A, Duarte-Silva S, Maciel P. Monteiro-Fernandes D, et al. Biomed Pharmacother. 2025 May;186:117989. doi: 10.1016/j.biopha.2025.117989. Epub 2025 Mar 22. Biomed Pharmacother. 2025. PMID: 40121895 Free article.
We report the effects of a drug candidate, NLX-101, a highly selective, biased agonist of 5-HT(1A) post-synaptic receptors at brainstem and cortical regions, on key phenotypes of RTT. Unrestrained whole-body plethysmography studies confirmed and extended the previou …
We report the effects of a drug candidate, NLX-101, a highly selective, biased agonist of 5-HT(1A) post-synaptic receptors at …
NLX-112 Randomized Phase 2A Trial: Safety, Tolerability, Anti-Dyskinetic, and Anti-Parkinsonian Efficacy.
Svenningsson P, Odin P, Bergquist F, Wirdefeldt K, Nyholm D, Andréasson M, Markaki I, Johansson AC, Jergil M, Jankosky C, Varney MA, Herbrecht F, Johnson SA, Newman-Tancredi A. Svenningsson P, et al. Mov Disord. 2025 Jun;40(6):1134-1142. doi: 10.1002/mds.30175. Epub 2025 Mar 17. Mov Disord. 2025. PMID: 40091754 Free PMC article. Clinical Trial.
OBJECTIVES: The primary objective was to evaluate the safety and tolerability of NLX-112 compared with placebo in people with PD. The secondary objective was to assess the preliminary efficacy of NLX-112 in reducing LID and its effects on PD symptoms. …
OBJECTIVES: The primary objective was to evaluate the safety and tolerability of NLX-112 compared with placebo in people with …
PET imaging of functional 5-HT(1A) receptors with [(18)F]F13640: From PET kinetics modeling to static Standardized Uptake Values Ratio.
Courault P, Mérida I, Costes N, Redoute J, Zimmer L, Lancelot S. Courault P, et al. Neuroimage. 2025 Apr 15;310:121110. doi: 10.1016/j.neuroimage.2025.121110. Epub 2025 Mar 8. Neuroimage. 2025. PMID: 40064318 Free article.
PURPOSE: F13640 is a highly selective serotonin 5-HT(1A) receptor ligand with agonist properties identified as a PET radiopharmaceutical candidate. In previous work, we showed the possibility to use long dynamic PET acquisition (225 min) combined with simplified kinetic mo …
PURPOSE: F13640 is a highly selective serotonin 5-HT(1A) receptor ligand with agonist properties identified as a PET radiopharmaceuti …
Long-Term 5-HT(1A) Receptor Agonist NLX-112 Treatment Improves Functional Recovery After Spinal Cord Injury.
Lin CY, Li K, Gitchell T, Lee YS. Lin CY, et al. Int J Mol Sci. 2024 Dec 30;26(1):239. doi: 10.3390/ijms26010239. Int J Mol Sci. 2024. PMID: 39796094 Free PMC article.
However, whether chronic activation of serotonin 5-HT(1A) receptors by NLX-112 after SCI is beneficial remains an unanswered question. Here, we evaluated the efficacy of long-term NLX-112 intervention starting from two weeks post-T8 contusive SCI for a …
However, whether chronic activation of serotonin 5-HT(1A) receptors by NLX-112 after SCI is beneficial remains an unanswered q …
Acute administration of NLX-101, a Serotonin 1A receptor agonist, improves auditory temporal processing during development in a mouse model of Fragile X Syndrome.
Tao X, Croom K, Newman-Tancredi A, Varney M, Razak KA. Tao X, et al. J Neurodev Disord. 2025 Jan 3;17(1):1. doi: 10.1186/s11689-024-09587-0. J Neurodev Disord. 2025. PMID: 39754065 Free PMC article.
In our previous study, we found that administration of the selective serotonin-1 A (5-HT(1A))receptor biased agonist, NLX-101, protected Fmr1 KO mice from auditory hypersensitivity-associated seizures. Here we tested the hypothesis that NLX-101 will no …
In our previous study, we found that administration of the selective serotonin-1 A (5-HT(1A))receptor biased agonist, NLX-101, …
Fentanyl dose-sparing in polyarthritic rats requires full agonism at 5-HT(1A) receptors: Comparison between NLX-112, ()8-OH-DPAT, and buspirone.
Depoortere R, Bardin L, Newman-Tancredi A. Depoortere R, et al. J Opioid Manag. 2024 Jul-Aug;20(4):269-274. doi: 10.5055/jom.0874. J Opioid Manag. 2024. PMID: 39321046
BACKGROUND: NLX-112 (a.k.a. F13640, befiradol) is a highly selective and fully efficacious agonist at 5-hydroxytryptamine (5-HT(1A)) receptors. ...Control infusions consisted of sterile 0.9 percent NaCl. RESULTS: NLX-112 (0.63 mg/day) sig …
BACKGROUND: NLX-112 (a.k.a. F13640, befiradol) is a highly selective and fully efficacious agonist at 5-hydroxyt …
Rapid reorganization of serotonin projections and antidepressant response to 5-HT1A-biased agonist NLX-101 in fluoxetine-resistant cF1ko mice.
Vahid-Ansari F, Newman-Tancredi A, Fuentes-Alvarenga AF, Daigle M, Albert PR. Vahid-Ansari F, et al. Neuropharmacology. 2024 Dec 15;261:110132. doi: 10.1016/j.neuropharm.2024.110132. Epub 2024 Aug 27. Neuropharmacology. 2024. PMID: 39208980 Free article.
Overall, NLX-101 was rapid and effective in reducing depressive behavior in SSRI-resistant mice, but also induced anxiety-related behaviors. The increase in serotonin innervation induced by intermittent NLX-101 may contribute to its behavioral actions. …
Overall, NLX-101 was rapid and effective in reducing depressive behavior in SSRI-resistant mice, but also induced anxiety-rela …
Preclinical investigation of the effect of stress on the binding of [(18)F]F13640, a 5-HT(1A) radiopharmaceutical.
Courault P, Bouvard S, Bouillot C, Zimmer L, Lancelot S. Courault P, et al. Nucl Med Biol. 2024 Nov-Dec;138-139:108942. doi: 10.1016/j.nucmedbio.2024.108942. Epub 2024 Jul 23. Nucl Med Biol. 2024. PMID: 39151306 Free article.
BACKGROUND: [(18)F]F13640 is a new PET radiopharmaceutical for brain molecular imaging of serotonin 5-HT(1A) receptors. ...Subsequently, a group of rats (n = 10) underwent two PET imaging acquisitions (baseline and PTSD condition) using the PET radiopharmaceutical [(18)F] …
BACKGROUND: [(18)F]F13640 is a new PET radiopharmaceutical for brain molecular imaging of serotonin 5-HT(1A) receptors. ...Subsequent …
Pharmacodynamic, pharmacokinetic and rat brain receptor occupancy profile of NLX-112, a highly selective 5-HT(1A) receptor biased agonist.
Depoortère RY, McCreary AC, Vidal B, Varney MA, Zimmer L, Newman-Tancredi A. Depoortère RY, et al. Naunyn Schmiedebergs Arch Pharmacol. 2025 Jan;398(1):991-1002. doi: 10.1007/s00210-024-03323-0. Epub 2024 Aug 3. Naunyn Schmiedebergs Arch Pharmacol. 2025. PMID: 39096379 Free article.
NLX-112 (i.e., F13640, befiradol) exhibits nanomolar affinity, exceptional selectivity and full agonist efficacy at serotonin 5-HT(1A) receptors. ...Co-administration of L-DOPA (6 mg/kg s.c., a dose used to elicit LID in parkinsonian rats) together wit …
NLX-112 (i.e., F13640, befiradol) exhibits nanomolar affinity, exceptional selectivity and full agonist efficacy …
104 results