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49 results

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Page 1
Wind-up and the NMDA receptor complex from a clinical perspective.
Eide PK. Eide PK. Eur J Pain. 2000;4(1):5-15. doi: 10.1053/eujp.1999.0154. Eur J Pain. 2000. PMID: 10833550 Review.
The experimental models used to explore mechanisms of central sensitization include the study of wind-up in animals and temporal summation of pain in humans. Wind-up was described more than 30 years ago as progressively increasing activity in dorsal …
The experimental models used to explore mechanisms of central sensitization include the study of wind-up in animals and tempor …
Dorsal horn NMDA receptor function is changed after peripheral inflammation.
Svendsen F, Rygh LJ, Hole K, Tjølsen A. Svendsen F, et al. Pain. 1999 Dec;83(3):517-523. doi: 10.1016/S0304-3959(99)00155-4. Pain. 1999. PMID: 10568860
Thus, other mechanisms than NMDA receptor stimulation may be more important for the wind-up in not sensitized dorsal horn neurons. As for long-term potentiation, it seems that NMDA receptor antagonists have an increased effect after sensi …
Thus, other mechanisms than NMDA receptor stimulation may be more important for the wind-up in not sensitized dorsal …
[Pre-emptive analgesia].
Wilder-Smith OH. Wilder-Smith OH. Anaesthesist. 1995 Dec;44 Suppl 3:S529-34. Anaesthesist. 1995. PMID: 8592963 Review. German.
These changes, most easily elicited by C-fibre afferents, particularly affect the spinal dorsal horn. Termed central sensitisation, they are reflected by reduced pain thresholds (allodynia), increased responses to pain (hyperalgesia), after-discharging or spo …
These changes, most easily elicited by C-fibre afferents, particularly affect the spinal dorsal horn. Termed central se …
Evidence for involvement of N-methylaspartate receptors in 'wind-up' of class 2 neurones in the dorsal horn of the rat.
Davies SN, Lodge D. Davies SN, et al. Brain Res. 1987 Oct 27;424(2):402-6. doi: 10.1016/0006-8993(87)91487-9. Brain Res. 1987. PMID: 2823998
We have examined the effects of ketamine and kynurenate on the initial response and frequency dependent potentiation of response (wind-up) of class 2 neurones of the rat dorsal horn induced by repeated electrical stimulation of their receptive fields. …
We have examined the effects of ketamine and kynurenate on the initial response and frequency dependent potentiation of response (wind …
Effect of an NMDA receptor antagonist on the wind-up of neurons in the trigeminal oralis subnucleus.
Parada CA, Luccarini P, Woda A. Parada CA, et al. Brain Res. 1997 Jul 4;761(2):313-20. doi: 10.1016/s0006-8993(97)00355-7. Brain Res. 1997. PMID: 9252031
The effects of MK801 on the first part of the wind-up response (wind-up proper) peaked between 15 and 50 min and returned to control values at about 80 min. ...It is concluded that despite being devoid of substantia gelatinosa, the oralis subnucleus co …
The effects of MK801 on the first part of the wind-up response (wind-up proper) peaked between 15 and 50 min and …
The role of N-methyl-D-aspartate (NMDA) receptors in wind-up: a mathematical model.
Britton NF, Chaplain MA, Skevington SM. Britton NF, et al. IMA J Math Appl Med Biol. 1996 Sep;13(3):193-205. IMA J Math Appl Med Biol. 1996. PMID: 8921589
We present a mathematical model for the phenomenon of wind-up (Mendell, 1966, Exper. Neur. 16,316-22) which occurs in many neurons. We concentrate on its occurrence in the substantia gelatinosa of the dorsal horns of the spinal cord, where it is …
We present a mathematical model for the phenomenon of wind-up (Mendell, 1966, Exper. Neur. 16,316-22) which occurs in many neu …
Gabapentin use in neuropathic pain syndromes.
Nicholson B. Nicholson B. Acta Neurol Scand. 2000 Jun;101(6):359-71. doi: 10.1034/j.1600-0404.2000.0006a.x. Acta Neurol Scand. 2000. PMID: 10877151 Review.
The development of neuropathic pain involves a series of changes including primary and secondary hyperalgesia, peripheral and central sensitization, and wind-up phenomena. Neurotransmitters play a critical role in this process. For example, glutaminergic subtypes of …
The development of neuropathic pain involves a series of changes including primary and secondary hyperalgesia, peripheral and central sensit …
The combination of NMDA antagonism and morphine produces profound antinociception in the rat dorsal horn.
Chapman V, Dickenson AH. Chapman V, et al. Brain Res. 1992 Feb 28;573(2):321-3. doi: 10.1016/0006-8993(92)90780-d. Brain Res. 1992. PMID: 1387029
Dorsal horn nociceptive neurones exhibit wind up, a frequency dependent potentiation of their responses to repeated C-fibre stimulation. Intrathecal morphine (5 micrograms) significantly reduces the initial responses of the neurones but not wind …
Dorsal horn nociceptive neurones exhibit wind up, a frequency dependent potentiation of their responses to repea …
Bi-directional effects of intrathecal NMDA and substance P on rat dorsal horn neuronal responses.
Chapman V, Dickenson AH, Tjølsen A. Chapman V, et al. Neurosci Lett. 1994 Aug 29;178(1):90-4. doi: 10.1016/0304-3940(94)90297-6. Neurosci Lett. 1994. PMID: 7529389
Intrathecal NMDA (5 ng) facilitated wind-up but not C-fibre evoked responses, whereas 50 ng facilitated C-fibre and A delta-fibre evoked responses but not wind-up of convergent dorsal horn neurones in the halothane anaesthetized ra …
Intrathecal NMDA (5 ng) facilitated wind-up but not C-fibre evoked responses, whereas 50 ng facilitated C-fibre and A d …
Cav1.2 and Cav1.3 L-type calcium channels independently control short- and long-term sensitization to pain.
Radwani H, Lopez-Gonzalez MJ, Cattaert D, Roca-Lapirot O, Dobremez E, Bouali-Benazzouz R, Eiríksdóttir E, Langel Ü, Favereaux A, Errami M, Landry M, Fossat P. Radwani H, et al. J Physiol. 2016 Nov 15;594(22):6607-6626. doi: 10.1113/JP272725. Epub 2016 Jul 3. J Physiol. 2016. PMID: 27231046 Free PMC article.
In dorsal horn neurons (DHNs), short-term sensitization can be monitored through the study of wind-up. ...In the dorsal horn of the spinal cord, two L-type calcium channels are present, Cav1.2 and Cav1.3, each displaying spe …
In dorsal horn neurons (DHNs), short-term sensitization can be monitored through the study of wind-up. ...In the …
49 results