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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1948 1
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1958 2
1959 8
1960 5
1961 9
1962 8
1963 8
1964 6
1965 2
1992 1
1993 1
1994 3
1995 4
1996 5
1997 10
1998 5
1999 20
2000 13
2001 14
2002 21
2003 35
2004 40
2005 32
2006 51
2007 45
2008 52
2009 56
2010 33
2011 49
2012 57
2013 66
2014 52
2015 66
2016 59
2017 70
2018 58
2019 70
2020 61
2021 82
2022 79
2023 58
2024 82
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2026 39

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1,373 results

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Page 1
Protective effect of Nr4a2 (Nurr1) against LPS-induced depressive-like behaviors via regulating activity of microglia and CamkII neurons in anterior cingulate cortex.
He Y, Wang Y, Yu H, Tian Y, Chen X, Chen C, Ren Y, Chen Z, Ren Y, Gong X, Cheng K, Liu X, Zhong L, Guo Y, Xie P. He Y, et al. Pharmacol Res. 2023 May;191:106717. doi: 10.1016/j.phrs.2023.106717. Epub 2023 Mar 21. Pharmacol Res. 2023. PMID: 36948326 Free article.
We applied fluoxetine (FLX) and amodiaquine dihydrochloride (AQ, a highly selective agonist of Nr4a2) in mice. Overexpression experiments were performed by injecting with AAV-Nr4a2-EGFP into ACC. ...Overexpression of Nr4a2 in ACC reversed the depressive- and …
We applied fluoxetine (FLX) and amodiaquine dihydrochloride (AQ, a highly selective agonist of Nr4a2) in mice. Overexpression experim …
Fam3a-mediated prohormone convertase switch in alpha-cells regulates pancreatic GLP-1 production in an Nr4a2-Foxa2-dependent manner.
Wang D, Wei T, Cui X, Xia L, Jiang Y, Yin D, Liao X, Li F, Li J, Wu Q, Lin X, Lang S, Le Y, Yang J, Yang J, Wei R, Hong T. Wang D, et al. Metabolism. 2025 Jan;162:156042. doi: 10.1016/j.metabol.2024.156042. Epub 2024 Oct 1. Metabolism. 2025. PMID: 39362520 Free article.
Nr4a2 silencing increased PC1/3 expression, albeit Nr4a2 did not directly bind to Pcsk1 promoter. Instead, Nr4a2 formed a complex with Foxa2 to facilitate Fam3a-mediated Foxa2 nuclear translocation. ...
Nr4a2 silencing increased PC1/3 expression, albeit Nr4a2 did not directly bind to Pcsk1 promoter. Instead, Nr4a2 formed …
PROKR1-CREB-NR4A2 axis for oxidative muscle fiber specification and improvement of metabolic function.
Mok J, Park JH, Yeom SC, Park J. Mok J, et al. Proc Natl Acad Sci U S A. 2024 Jan 23;121(4):e2308960121. doi: 10.1073/pnas.2308960121. Epub 2024 Jan 17. Proc Natl Acad Sci U S A. 2024. PMID: 38232288 Free PMC article.
Genetic and pharmacological interventions showed that the PROKR1-NR4A2 axis promotes the specification of oxidative muscle fibers in both myocytes by promoting mitochondrial biogenesis and metabolic function. ...The deletion of Prokr1 resulted in decreased oxidative muscle …
Genetic and pharmacological interventions showed that the PROKR1-NR4A2 axis promotes the specification of oxidative muscle fibers in …
The NR4A2/VGF pathway fuels inflammation-induced neurodegeneration via promoting neuronal glycolysis.
Woo MS, Bal LC, Winschel I, Manca E, Walkenhorst M, Sevgili B, Sonner JK, Di Liberto G, Mayer C, Binkle-Ladisch L, Rothammer N, Unger L, Raich L, Hadjilaou A, Noli B, Manai AL, Vieira V, Meurs N, Wagner I, Pless O, Cocco C, Stephens SB, Glatzel M, Merkler D, Friese MA. Woo MS, et al. J Clin Invest. 2024 Jun 18;134(16):e177692. doi: 10.1172/JCI177692. J Clin Invest. 2024. PMID: 39145444 Free PMC article.
This revealed a prominent induction of the nuclear receptor NR4A2 in neurons. Mechanistically, NR4A2 increased susceptibility to excitotoxicity by stimulating continuous VGF secretion leading to glycolysis-dependent neuronal cell death. ...
This revealed a prominent induction of the nuclear receptor NR4A2 in neurons. Mechanistically, NR4A2 increased susceptibility …
Regulation of NR4A2 Gene Expression and Its Importance in Neurodegenerative and Psychiatric Diseases.
Ruiz-Sánchez E, Rojas C, Yescas Gómez P, Martínez-Rodríguez N, Ruiz-Chow ÁA, Nava-Ruiz C, Ibáñéz-Cervantes G, Arciniega-Martínez IM, Reséndiz-Albor AA, Rojas P. Ruiz-Sánchez E, et al. Int J Mol Sci. 2025 Sep 19;26(18):9162. doi: 10.3390/ijms26189162. Int J Mol Sci. 2025. PMID: 41009723 Free PMC article. Review.
The gene encoding this transcription factor is called NR4A2 and has been identified as an immediate early gene. Moreover, research in animal models and clinical trials has suggested an association between reduced NR4A2 gene expression and some neurodegenerative dise …
The gene encoding this transcription factor is called NR4A2 and has been identified as an immediate early gene. Moreover, research in …
Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction: A Perspective Review.
Català-Solsona J, Miñano-Molina AJ, Rodríguez-Álvarez J. Català-Solsona J, et al. Front Mol Neurosci. 2021 Nov 22;14:786226. doi: 10.3389/fnmol.2021.786226. eCollection 2021. Front Mol Neurosci. 2021. PMID: 34880728 Free PMC article. Review.
Recent studies have also pointed out a role for the activity-dependent nuclear receptor subfamily 4, group A, member 2 (Nr4a2/Nurr1) in hippocampal synaptic plasticity and cognitive functions, although the underlying molecular mechanisms are still poorly understood. In thi …
Recent studies have also pointed out a role for the activity-dependent nuclear receptor subfamily 4, group A, member 2 (Nr4a2/Nurr1) …
NR4A2 as a Novel Target Gene for Developmental and Epileptic Encephalopathy: A Systematic Review of Related Disorders and Therapeutic Strategies.
Gabaldon-Albero A, Mayo S, Martinez F. Gabaldon-Albero A, et al. Int J Mol Sci. 2024 May 10;25(10):5198. doi: 10.3390/ijms25105198. Int J Mol Sci. 2024. PMID: 38791237 Free PMC article.
The NR4A2 gene encodes an orphan transcription factor of the steroid-thyroid hormone-retinoid receptor superfamily. ...The age at onset varied widely, from five months to twenty-six years, as did the classification of epilepsy, which ranged from focal epilepsy to infantile …
The NR4A2 gene encodes an orphan transcription factor of the steroid-thyroid hormone-retinoid receptor superfamily. ...The age at ons …
NR4A2 attenuates early brain injury after intracerebral hemorrhage by promoting M2 microglial polarization via TLR4/TRAF6/NF-kappaB pathway inhibition.
Hu D, Huang C, Tang L, Lei J, Wang J, Hu W, Chen M, Song S, Lu L, Xu P. Hu D, et al. Cell Mol Life Sci. 2025 Jun 28;82(1):262. doi: 10.1007/s00018-025-05755-0. Cell Mol Life Sci. 2025. PMID: 40580316 Free PMC article.
Recent studies have shown that the nuclear receptor-related 1 protein (NR4A2) can regulate microglial function and inhibit inflammation. However, the functions of NR4A2 in the development of ICH are still unclear. ...Conversely, the protective effects of NR4A2 …
Recent studies have shown that the nuclear receptor-related 1 protein (NR4A2) can regulate microglial function and inhibit inflammati …
Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma.
Ye Z, Ai X, Yang K, Yang Z, Fei F, Liao X, Qiu Z, Gimple RC, Yuan H, Huang H, Gong Y, Xiao C, Yue J, Huang L, Saulnier O, Wang W, Zhang P, Dai L, Wang X, Wang X, Ahn YH, You C, Xu J, Wan X, Taylor MD, Zhao L, Rich JN, Zhou S. Ye Z, et al. Cancer Discov. 2023 Apr 3;13(4):974-1001. doi: 10.1158/2159-8290.CD-22-0455. Cancer Discov. 2023. PMID: 36649564 Free PMC article.
Here, single-cell sequencing of the GBM TIME revealed that microglia were under severe oxidative stress, which induced nuclear receptor subfamily 4 group A member 2 (NR4A2)-dependent transcriptional activity in microglia. Heterozygous Nr4a2 (Nr4a2+/-) or CX3C …
Here, single-cell sequencing of the GBM TIME revealed that microglia were under severe oxidative stress, which induced nuclear receptor subf …
NR4A2 genetic variation and Parkinson's disease: Evidence from a systematic review and meta-analysis.
Liu H, Liu H, Li T, Cui J, Fu Y, Ren J, Sun X, Jiang P, Yu S, Li C. Liu H, et al. Neurosci Lett. 2017 May 22;650:25-32. doi: 10.1016/j.neulet.2017.01.062. Epub 2017 Apr 4. Neurosci Lett. 2017. PMID: 28385514
INTRODUCTION: The homo sapiens nuclear receptor subfamily 4, group A (NR4A2) genetic variation has been implicated as a risk factor for Parkinson's disease (PD). ...CONCLUSION: The study comprehensively evaluated the association of NR4A2 variation with PD, and the r …
INTRODUCTION: The homo sapiens nuclear receptor subfamily 4, group A (NR4A2) genetic variation has been implicated as a risk factor f …
1,373 results