Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1.
Wang W, Yang J, Liu H, Lu D, Chen X, Zenonos Z, Campos LS, Rad R, Guo G, Zhang S, Bradley A, Liu P.
Wang W, et al.
Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18283-8. doi: 10.1073/pnas.1100893108. Epub 2011 Oct 11.
Proc Natl Acad Sci U S A. 2011.
PMID: 21990348
Free PMC article.
Here we report that enhancing RA signaling by expressing RA receptors (RARs) or by RA agonists profoundly promoted reprogramming, but inhibiting it using a RAR-alpha dominant-negative form completely blocked it. Coexpressing Rarg (RAR-gamma) and Lrh-1 (liver receptor homol …
Here we report that enhancing RA signaling by expressing RA receptors (RARs) or by RA agonists profoundly promoted reprogramming, but inhibi …