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Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve.
Hughes CHK, Smith OE, Meinsohn MC, Brunelle M, Gévry N, Murphy BD. Hughes CHK, et al. Proc Natl Acad Sci U S A. 2023 Aug 8;120(32):e2220849120. doi: 10.1073/pnas.2220849120. Epub 2023 Jul 26. Proc Natl Acad Sci U S A. 2023. PMID: 37494420 Free PMC article.
Steroidogenic factor 1 (SF-1; Nr5a1) and liver receptor homolog 1 (LRH-1; Nr5a2) are two orphan nuclear receptors that regulate adult endocrine function, but their role in follicle formation is unknown. ...
Steroidogenic factor 1 (SF-1; Nr5a1) and liver receptor homolog 1 (LRH-1; Nr5a2) are two orphan nuclear receptors that regulat …
Molecular mechanisms of DAX1 action.
Iyer AK, McCabe ER. Iyer AK, et al. Mol Genet Metab. 2004 Sep-Oct;83(1-2):60-73. doi: 10.1016/j.ymgme.2004.07.018. Mol Genet Metab. 2004. PMID: 15464421 Review.
Recent evidence suggests a broader functional role for DAX1 as a negative coregulator of estrogen receptor (ER, NR3A1-2), liver receptor homologue-1 (LRH-1, NR5A2), androgen receptor (AR, NR3C4), and progesterone receptor (PR, NR3C3), each by distinct repression mec …
Recent evidence suggests a broader functional role for DAX1 as a negative coregulator of estrogen receptor (ER, NR3A1-2), liver recep …
Therapeutic potential of Liver Receptor Homolog-1 modulators.
Lazarus KA, Wijayakumara D, Chand AL, Simpson ER, Clyne CD. Lazarus KA, et al. J Steroid Biochem Mol Biol. 2012 Jul;130(3-5):138-46. doi: 10.1016/j.jsbmb.2011.12.017. Epub 2012 Jan 14. J Steroid Biochem Mol Biol. 2012. PMID: 22266285 Review.
Liver Receptor Homolog-1 (LRH-1; NR5A2) belongs to the orphan nuclear receptor superfamily, and plays vital roles in early development, cholesterol homeostasis, steroidogenesis and certain diseases, including cancer. It is expressed in embryonic stem cells, adult …
Liver Receptor Homolog-1 (LRH-1; NR5A2) belongs to the orphan nuclear receptor superfamily, and plays vital roles in early dev …
Liver receptor homolog-1 (LRH-1): a potential therapeutic target for cancer.
Nadolny C, Dong X. Nadolny C, et al. Cancer Biol Ther. 2015;16(7):997-1004. doi: 10.1080/15384047.2015.1045693. Epub 2015 May 7. Cancer Biol Ther. 2015. PMID: 25951367 Free PMC article. Review.
Liver receptor homolog-1 (LRH-1) is a nuclear receptor involved in various biological processes. This nuclear receptor has critical functions in embryonic development as well as in adult homeostasis. Although the physiological functions of LRH-1 in normal breast, pa …
Liver receptor homolog-1 (LRH-1) is a nuclear receptor involved in various biological processes. This nuclear receptor has critical f …
Liver receptor homologue-1 and steroidogenic factor-1 expression in cultured granulosa cells from patients with endometriosis: A preliminary study.
Lu X, Wu ZM, Wang YW, Wang M, Cheng WW. Lu X, et al. J Obstet Gynaecol Res. 2015 Dec;41(12):1927-34. doi: 10.1111/jog.12832. Epub 2015 Nov 4. J Obstet Gynaecol Res. 2015. PMID: 26530052
AIM: The expression of aromatase (via CYP19 and the CYP19 PII promoter) and the orphan nuclear receptor family members, liver receptor homologue-1 (LRH-1) and steroidogenic factor-1 (SF-1) in cultured luteinized granulosa cells from women with endometriosis were investigat …
AIM: The expression of aromatase (via CYP19 and the CYP19 PII promoter) and the orphan nuclear receptor family members, liver recepto …
Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1.
Wang W, Yang J, Liu H, Lu D, Chen X, Zenonos Z, Campos LS, Rad R, Guo G, Zhang S, Bradley A, Liu P. Wang W, et al. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18283-8. doi: 10.1073/pnas.1100893108. Epub 2011 Oct 11. Proc Natl Acad Sci U S A. 2011. PMID: 21990348 Free PMC article.
Coexpressing Rarg (RAR-gamma) and Lrh-1 (liver receptor homologue 1; Nr5a2) with the four factors greatly accelerated reprogramming so that reprogramming of mouse embryonic fibroblast cells to ground-state iPSCs requires only 4 d induction of these six factors. The …
Coexpressing Rarg (RAR-gamma) and Lrh-1 (liver receptor homologue 1; Nr5a2) with the four factors greatly accelerated reprogra …
Expression of Liver Receptor Homolog-1 (LRH-1) in Villi and Decidua of Patients with Unexplained Recurrent Spontaneous Abortion.
Xu Z, Hou X, Lv H, Sun B, Cui Y, Liu L, Rong F. Xu Z, et al. Med Sci Monit. 2017 May 22;23:2445-2452. doi: 10.12659/msm.904645. Med Sci Monit. 2017. PMID: 28531169 Free PMC article.
BACKGROUND In view of the important function of nuclear receptor liver receptor homolog 1 (LRH 1) in various biological processes and the physiological changes accompanying unexplained recurrent spontaneous abortion (USRA), our study was carried out to investigate the pote …
BACKGROUND In view of the important function of nuclear receptor liver receptor homolog 1 (LRH 1) in various biological processes and …
HBx induced AFP receptor expressed to activate PI3K/AKT signal to promote expression of Src in liver cells and hepatoma cells.
Zhu M, Guo J, Li W, Xia H, Lu Y, Dong X, Chen Y, Xie X, Fu S, Li M. Zhu M, et al. BMC Cancer. 2015 May 6;15:362. doi: 10.1186/s12885-015-1384-9. BMC Cancer. 2015. PMID: 25943101 Free PMC article.
METHODS: A total of 71 clinical patients' liver specimens, normal human liver cells L-02 and HCC cell lines, PLC/PRF/5 were selected for analyzing the effects of HBx on expression of AFP, AFPR and Src. ...CONCLUSIONS: HBx priors to drive the expression of AFP and AF …
METHODS: A total of 71 clinical patients' liver specimens, normal human liver cells L-02 and HCC cell lines, PLC/PRF/5 were se …
The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1.
Wang W, Zhang C, Marimuthu A, Krupka HI, Tabrizizad M, Shelloe R, Mehra U, Eng K, Nguyen H, Settachatgul C, Powell B, Milburn MV, West BL. Wang W, et al. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7505-10. doi: 10.1073/pnas.0409482102. Epub 2005 May 16. Proc Natl Acad Sci U S A. 2005. PMID: 15897460 Free PMC article.
Steroidogenic factor-1 (SF-1) and liver receptor homologue-1 (LRH-1) belong to the fushi tarazu factor 1 subfamily of nuclear receptors. SF-1 is an essential factor for sex determination during development and regulates adrenal and gonadal steroidogenesis in the adult …
Steroidogenic factor-1 (SF-1) and liver receptor homologue-1 (LRH-1) belong to the fushi tarazu factor 1 subfamily of nuclear recepto …
Liver receptor homologue-1 is expressed in the adrenal and can regulate transcription of 11 beta-hydroxylase.
Wang ZN, Bassett M, Rainey WE. Wang ZN, et al. J Mol Endocrinol. 2001 Oct;27(2):255-8. doi: 10.1677/jme.0.0270255. J Mol Endocrinol. 2001. PMID: 11564608
Liver receptor homologue-1 (LRH-1, designated NR5A2) is a mammalian homologue of Drosophila fushi tarazu factor (dFTZ-F1) and structurally belongs to the orphan nuclear receptor superfamily. ...To test this hypothesis, LRH-1 expression in human adult and feta …
Liver receptor homologue-1 (LRH-1, designated NR5A2) is a mammalian homologue of Drosophila fushi tarazu factor (dFTZ-F1) and …
47 results