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Year Number of Results
1997 1
2001 1
2003 4
2004 4
2005 5
2006 4
2007 4
2008 1
2009 1
2010 2
2011 4
2012 3
2013 2
2015 6
2017 3
2018 3
2020 0
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LRH-1 regulates hepatic lipid homeostasis and maintains arachidonoyl phospholipid pools critical for phospholipid diversity.
Miranda DA, Krause WC, Cazenave-Gassiot A, Suzawa M, Escusa H, Foo JC, Shihadih DS, Stahl A, Fitch M, Nyangau E, Hellerstein M, Wenk MR, Silver DL, Ingraham HA. Miranda DA, et al. JCI Insight. 2018 Mar 8;3(5):e96151. doi: 10.1172/jci.insight.96151. JCI Insight. 2018. PMID: 29515023 Free PMC article.
Excess lipid accumulation is an early signature of nonalcoholic fatty liver disease (NAFLD). Although liver receptor homolog 1 (LRH-1) (encoded by NR5A2) is suppressed in human NAFLD, evidence linking this phospholipid-bound nuclear receptor to hepatic lipid …
Excess lipid accumulation is an early signature of nonalcoholic fatty liver disease (NAFLD). Although liver receptor homolog 1 …
Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer.
Childs EJ, Mocci E, Campa D, Bracci PM, Gallinger S, Goggins M, Li D, Neale RE, Olson SH, Scelo G, Amundadottir LT, Bamlet WR, Bijlsma MF, Blackford A, Borges M, Brennan P, Brenner H, Bueno-de-Mesquita HB, Canzian F, Capurso G, Cavestro GM, Chaffee KG, Chanock SJ, Cleary SP, Cotterchio M, Foretova L, Fuchs C, Funel N, Gazouli M, Hassan M, Herman JM, Holcatova I, Holly EA, Hoover RN, Hung RJ, Janout V, Key TJ, Kupcinskas J, Kurtz RC, Landi S, Lu L, Malecka-Panas E, Mambrini A, Mohelnikova-Duchonova B, Neoptolemos JP, Oberg AL, Orlow I, Pasquali C, Pezzilli R, Rizzato C, Saldia A, Scarpa A, Stolzenberg-Solomon RZ, Strobel O, Tavano F, Vashist YK, Vodicka P, Wolpin BM, Yu H, Petersen GM, Risch HA, Klein AP. Childs EJ, et al. Nat Genet. 2015 Aug;47(8):911-6. doi: 10.1038/ng.3341. Epub 2015 Jun 22. Nat Genet. 2015. PMID: 26098869 Free PMC article.
We replicated previously reported associations at 9q34.2 (ABO), 13q22.1 (KLF5), 5p15.33 (TERT and CLPTM1), 13q12.2 (PDX1), 1q32.1 (NR5A2), 7q32.3 (LINC-PINT), 16q23.1 (BCAR1) and 22q12.1 (ZNRF3). ...
We replicated previously reported associations at 9q34.2 (ABO), 13q22.1 (KLF5), 5p15.33 (TERT and CLPTM1), 13q12.2 (PDX1), 1q32.1 (NR5A2 …
Expression of Liver Receptor Homolog-1 (LRH-1) in Villi and Decidua of Patients with Unexplained Recurrent Spontaneous Abortion.
Xu Z, Hou X, Lv H, Sun B, Cui Y, Liu L, Rong F. Xu Z, et al. Med Sci Monit. 2017 May 22;23:2445-2452. doi: 10.12659/msm.904645. Med Sci Monit. 2017. PMID: 28531169 Free PMC article.
BACKGROUND In view of the important function of nuclear receptor liver receptor homolog 1 (LRH 1) in various biological processes and the physiological changes accompanying unexplained recurrent spontaneous abortion (USRA), our study was carried out to investigate the pote …
BACKGROUND In view of the important function of nuclear receptor liver receptor homolog 1 (LRH 1) in various biological processes and …
HBx induced AFP receptor expressed to activate PI3K/AKT signal to promote expression of Src in liver cells and hepatoma cells.
Zhu M, Guo J, Li W, Xia H, Lu Y, Dong X, Chen Y, Xie X, Fu S, Li M. Zhu M, et al. BMC Cancer. 2015 May 6;15:362. doi: 10.1186/s12885-015-1384-9. BMC Cancer. 2015. PMID: 25943101 Free PMC article.
METHODS: A total of 71 clinical patients' liver specimens, normal human liver cells L-02 and HCC cell lines, PLC/PRF/5 were selected for analyzing the effects of HBx on expression of AFP, AFPR and Src. ...RESULTS: We confirmed HBx gives preference to promote the exp …
METHODS: A total of 71 clinical patients' liver specimens, normal human liver cells L-02 and HCC cell lines, PLC/PRF/5 were se …
Liver receptor homologue-1 and steroidogenic factor-1 expression in cultured granulosa cells from patients with endometriosis: A preliminary study.
Lu X, Wu ZM, Wang YW, Wang M, Cheng WW. Lu X, et al. J Obstet Gynaecol Res. 2015 Dec;41(12):1927-34. doi: 10.1111/jog.12832. Epub 2015 Nov 4. J Obstet Gynaecol Res. 2015. PMID: 26530052
AIM: The expression of aromatase (via CYP19 and the CYP19 PII promoter) and the orphan nuclear receptor family members, liver receptor homologue-1 (LRH-1) and steroidogenic factor-1 (SF-1) in cultured luteinized granulosa cells from women with endometriosis were investigat …
AIM: The expression of aromatase (via CYP19 and the CYP19 PII promoter) and the orphan nuclear receptor family members, liver recepto …
Localization and regulation of aromatase liver receptor homologue-1 in the developing rat testis.
Sierens J, Jakody I, Poobalan Y, Meachem SJ, Knower K, Young MJ, Sirianni R, Pezzi V, Clyne CD. Sierens J, et al. Mol Cell Endocrinol. 2010 Jul 29;323(2):307-13. doi: 10.1016/j.mce.2010.03.001. Epub 2010 Mar 7. Mol Cell Endocrinol. 2010. PMID: 20214950
In adult animals higher levels of expression were observed in Leydig and germ cells. Over-expression of LRH-1 in primary rat Leydig and germ cells by adenoviral infection strongly increased endogenous aromatase mRNA levels, demonstrating the ability of LRH-1 to stimulate a …
In adult animals higher levels of expression were observed in Leydig and germ cells. Over-expression of LRH-1 in primary rat Leydig a …
Expression and functional analysis of liver receptor homologue 1 as a potential steroidogenic factor in rat ovary.
Liu DL, Liu WZ, Li QL, Wang HM, Qian D, Treuter E, Zhu C. Liu DL, et al. Biol Reprod. 2003 Aug;69(2):508-17. doi: 10.1095/biolreprod.102.011767. Epub 2003 Apr 2. Biol Reprod. 2003. PMID: 12672674
Liver receptor homologue 1 (LRH-1) is a member of the nuclear receptor superfamily originally found in liver cells. LRH-1 participates in regulation of cholesterol metabolism and bile acid synthesis. ...LRH-1 mRNA and protein were primarily localized to granulosa ce …
Liver receptor homologue 1 (LRH-1) is a member of the nuclear receptor superfamily originally found in liver cells. LRH-1 part …
Liver receptor homologue-1 is expressed in the adrenal and can regulate transcription of 11 beta-hydroxylase.
Wang ZN, Bassett M, Rainey WE. Wang ZN, et al. J Mol Endocrinol. 2001 Oct;27(2):255-8. doi: 10.1677/jme.0.0270255. J Mol Endocrinol. 2001. PMID: 11564608
Liver receptor homologue-1 (LRH-1, designated NR5A2) is a mammalian homologue of Drosophila fushi tarazu factor (dFTZ-F1) and structurally belongs to the orphan nuclear receptor superfamily. ...To test this hypothesis, LRH-1 expression in human adult and feta …
Liver receptor homologue-1 (LRH-1, designated NR5A2) is a mammalian homologue of Drosophila fushi tarazu factor (dFTZ-F1) and …
Regulation by FSH of the dynamic expression of retinol-binding protein 4 in the mouse ovary.
Jiang Y, Zhao Y, Chen S, Chen L, Li C, Zhou X. Jiang Y, et al. Reprod Biol Endocrinol. 2018 Mar 20;16(1):25. doi: 10.1186/s12958-018-0348-8. Reprod Biol Endocrinol. 2018. PMID: 29558965 Free PMC article.
METHODS: The expression pattern of ovarian Rbp4 was examined in immature mice during different developmental stages and in adult mice during different stages of the estrous cycle. ...In adult female mice, the expression of Rbp4 increased at proestrus and peaked at e …
METHODS: The expression pattern of ovarian Rbp4 was examined in immature mice during different developmental stages and in adult mice …
Nuclear receptor NR5A2 is required for proper primitive streak morphogenesis.
Labelle-Dumais C, Jacob-Wagner M, Paré JF, Bélanger L, Dufort D. Labelle-Dumais C, et al. Dev Dyn. 2006 Dec;235(12):3359-69. doi: 10.1002/dvdy.20996. Dev Dyn. 2006. PMID: 17075876 Free article.
NR5A2, also known as liver receptor homologue 1 (LRH-1) and fetoprotein transcription factor (FTF), is an orphan nuclear receptor involved in the regulation of cholesterol metabolism and steroidogenesis in the adult. ...To characterize the embryonic phenotype …
NR5A2, also known as liver receptor homologue 1 (LRH-1) and fetoprotein transcription factor (FTF), is an orphan nuclear recep …
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