Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1998 3
2001 4
2002 5
2003 13
2004 15
2005 25
2006 13
2007 17
2008 10
2009 17
2010 18
2011 21
2012 23
2013 25
2014 21
2015 31
2016 29
2017 27
2018 39
2019 41
2020 44
2021 56
2022 52
2023 61
2024 51
2025 70
2026 8

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

650 results

Results by year

Filters applied: . Clear all
Page 1
Chromatin regulation of transcriptional enhancers and cell fate by the Sotos syndrome gene NSD1.
Sun Z, Lin Y, Islam MT, Koche R, Hedehus L, Liu D, Huang C, Vierbuchen T, Sawyers CL, Helin K. Sun Z, et al. Mol Cell. 2023 Jul 20;83(14):2398-2416.e12. doi: 10.1016/j.molcel.2023.06.007. Epub 2023 Jul 3. Mol Cell. 2023. PMID: 37402365 Free PMC article.
Despite the impacts of H3K36me2 on H3K27me3 and DNA methylation, the direct role of NSD1 in transcriptional regulation remains largely unknown. Here, we show that NSD1 and H3K36me2 are enriched at cis-regulatory elements, particularly enhancers. ...By combining acut …
Despite the impacts of H3K36me2 on H3K27me3 and DNA methylation, the direct role of NSD1 in transcriptional regulation remains largel …
Role of NSD1 as potential therapeutic target in tumor.
Yang C, Wang K, Liang Q, Tian TT, Zhong Z. Yang C, et al. Pharmacol Res. 2021 Nov;173:105888. doi: 10.1016/j.phrs.2021.105888. Epub 2021 Sep 16. Pharmacol Res. 2021. PMID: 34536546 Review.
Therefore, targeting NSD1 may be a potential strategy for tumor therapy. An in-depth study of the structure and biological activities of NSD1 sets the groundwork for improving tumor therapy and creating NSD1 inhibitors. This article emphasizes the role of …
Therefore, targeting NSD1 may be a potential strategy for tumor therapy. An in-depth study of the structure and biological activities …
NSD1: A Lysine Methyltransferase between Developmental Disorders and Cancer.
Tauchmann S, Schwaller J. Tauchmann S, et al. Life (Basel). 2021 Aug 25;11(9):877. doi: 10.3390/life11090877. Life (Basel). 2021. PMID: 34575025 Free PMC article. Review.
Recurrent epigenomic alterations associated with multiple human pathologies have increased the interest in the nuclear receptor binding SET domain protein 1 (NSD1) lysine methyltransferase. Here, we review the current knowledge about the biochemistry, cellular function and …
Recurrent epigenomic alterations associated with multiple human pathologies have increased the interest in the nuclear receptor binding SET …
H3K36 methyltransferase NSD1 protects against osteoarthritis through regulating chondrocyte differentiation and cartilage homeostasis.
Shao R, Suo J, Zhang Z, Kong M, Ma Y, Wen Y, Liu M, Zhuang L, Ge K, Bi Q, Zhang C, Zou W. Shao R, et al. Cell Death Differ. 2024 Jan;31(1):106-118. doi: 10.1038/s41418-023-01244-8. Epub 2023 Nov 27. Cell Death Differ. 2024. PMID: 38012390 Free PMC article.
Immunostaining results showed decreased anabolic and increased catabolic activities in Nsd1(Prrx1-Cre) mice, along with decreased chondrogenic differentiation. Transcriptome and ChIP-seq data revealed that Osr2 was a key factor affected by Nsd1. Intra-articular deli …
Immunostaining results showed decreased anabolic and increased catabolic activities in Nsd1(Prrx1-Cre) mice, along with decreased cho …
Lysine Methyltransferase NSD1 and Cancers: Any Role in Melanoma?
Krossa I, Strub T, Aplin AE, Ballotti R, Bertolotto C. Krossa I, et al. Cancers (Basel). 2022 Oct 5;14(19):4865. doi: 10.3390/cancers14194865. Cancers (Basel). 2022. PMID: 36230787 Free PMC article. Review.
We then report the role of NSD1 in triggering tumor suppressive or promoter functions according to the tissue context and we discuss the role of NSD1 in melanoma. Finally, we examine the ongoing efforts to target NSD1 signaling in cancers....
We then report the role of NSD1 in triggering tumor suppressive or promoter functions according to the tissue context and we discuss …
NSD1 promotes esophageal cancer tumorigenesis via HIF1alpha signaling.
He F, Xiao H, Cai Y, Zhang N. He F, et al. Cell Biol Toxicol. 2023 Aug;39(4):1835-1850. doi: 10.1007/s10565-022-09786-2. Epub 2022 Dec 16. Cell Biol Toxicol. 2023. PMID: 36522543
However, the role of NSD1 in tumorigenesis remains elusive. Here, we evaluated the relationship between NSD1 signaling and HIF1 signaling. ...In vivo xenograft experiments further confirmed that HIF1alpha and STAT3 maintenance is essential for NSD1-mediated t …
However, the role of NSD1 in tumorigenesis remains elusive. Here, we evaluated the relationship between NSD1 signaling and HIF …
Genotype-phenotype associations in Sotos syndrome: an analysis of 266 individuals with NSD1 aberrations.
Tatton-Brown K, Douglas J, Coleman K, Baujat G, Cole TR, Das S, Horn D, Hughes HE, Temple IK, Faravelli F, Waggoner D, Turkmen S, Cormier-Daire V, Irrthum A, Rahman N; Childhood Overgrowth Collaboration. Tatton-Brown K, et al. Am J Hum Genet. 2005 Aug;77(2):193-204. doi: 10.1086/432082. Epub 2005 Jun 7. Am J Hum Genet. 2005. PMID: 15942875 Free PMC article.
We identified 266 individuals with intragenic NSD1 mutations or 5q35 microdeletions encompassing NSD1 (referred to as "NSD1-positive individuals"), through analyses of 530 subjects with diverse phenotypes. ...Sotos syndrome was clinically diagnosed in 99% of …
We identified 266 individuals with intragenic NSD1 mutations or 5q35 microdeletions encompassing NSD1 (referred to as "NSD1 …
NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition.
Drosos Y, Myers JA, Xu B, Mathias KM, Beane EC, Radko-Juettner S, Mobley RJ, Larsen ME, Piccioni F, Ma X, Low J, Hansen BS, Peters ST, Bhanu NV, Dhanda SK, Chen T, Upadhyaya SA, Pruett-Miller SM, Root DE, Garcia BA, Partridge JF, Roberts CWM. Drosos Y, et al. Mol Cell. 2022 Jul 7;82(13):2472-2489.e8. doi: 10.1016/j.molcel.2022.04.015. Epub 2022 May 9. Mol Cell. 2022. PMID: 35537449 Free PMC article.
We found that loss of the H3K36 methyltransferase NSD1 caused resistance to EZH2 inhibition. We show that NSD1 antagonizes polycomb via cooperation with SWI/SNF and identify co-occurrence of NSD1 inactivation in SWI/SNF-defective cancers, indicating in vivo r …
We found that loss of the H3K36 methyltransferase NSD1 caused resistance to EZH2 inhibition. We show that NSD1 antagonizes pol …
NSD1 mutations in Sotos syndrome.
Faravelli F. Faravelli F. Am J Med Genet C Semin Med Genet. 2005 Aug 15;137C(1):24-31. doi: 10.1002/ajmg.c.30061. Am J Med Genet C Semin Med Genet. 2005. PMID: 16010675 Review.
Sotos syndrome is a genetic disorder characterized by a typical facial appearance, macrocephaly, accelerated growth, developmental delay, and a variable range of associated abnormalities. The NSD1 gene was recently found to be responsible for Sotos syndrome, and more than …
Sotos syndrome is a genetic disorder characterized by a typical facial appearance, macrocephaly, accelerated growth, developmental delay, an …
NSD1 gene evolves under episodic selection within primates and mutations of specific exons in humans cause Sotos syndrome.
Romero VI, Arias-Almeida B, Aguiar SA. Romero VI, et al. BMC Genomics. 2022 Dec 22;23(1):849. doi: 10.1186/s12864-022-09071-w. BMC Genomics. 2022. PMID: 36550402 Free PMC article.
We aimed to understand if NSD1 in humans differs from other primates since the evolution of NSD1 has not been analyzed in primates, nor if the localization of the mutations is limited to humans. ...Most of the domains are conserved in distant primates with a particu …
We aimed to understand if NSD1 in humans differs from other primates since the evolution of NSD1 has not been analyzed in prim …
650 results