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Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper.
Palmer E, Naeher D. Palmer E, et al. Among authors: naeher d. Nat Rev Immunol. 2009 Mar;9(3):207-13. doi: 10.1038/nri2469. Nat Rev Immunol. 2009. PMID: 19151748 Review.
The T cell receptor's alpha-chain connecting peptide motif promotes close approximation of the CD8 coreceptor allowing efficient signal initiation.
Mallaun M, Naeher D, Daniels MA, Yachi PP, Hausmann B, Luescher IF, Gascoigne NR, Palmer E. Mallaun M, et al. Among authors: naeher d. J Immunol. 2008 Jun 15;180(12):8211-21. doi: 10.4049/jimmunol.180.12.8211. J Immunol. 2008. PMID: 18523287 Free PMC article.
A constant affinity threshold for T cell tolerance.
Naeher D, Daniels MA, Hausmann B, Guillaume P, Luescher I, Palmer E. Naeher D, et al. J Exp Med. 2007 Oct 29;204(11):2553-9. doi: 10.1084/jem.20070254. Epub 2007 Oct 15. J Exp Med. 2007. PMID: 17938233 Free PMC article.
T cell division and death are segregated by mutation of TCRbeta chain constant domains.
Teixeiro E, Daniels MA, Hausmann B, Schrum AG, Naeher D, Luescher I, Thome M, Bragado R, Palmer E. Teixeiro E, et al. Among authors: naeher d. Immunity. 2004 Oct;21(4):515-26. doi: 10.1016/j.immuni.2004.08.014. Immunity. 2004. PMID: 15485629 Free article.
Signaling life and death in the thymus: timing is everything.
Werlen G, Hausmann B, Naeher D, Palmer E. Werlen G, et al. Among authors: naeher d. Science. 2003 Mar 21;299(5614):1859-63. doi: 10.1126/science.1067833. Science. 2003. PMID: 12649474 Review.
CD3 delta establishes a functional link between the T cell receptor and CD8.
Doucey MA, Goffin L, Naeher D, Michielin O, Baumgärtner P, Guillaume P, Palmer E, Luescher IF. Doucey MA, et al. Among authors: naeher d. J Biol Chem. 2003 Jan 31;278(5):3257-64. doi: 10.1074/jbc.M208119200. Epub 2002 Sep 4. J Biol Chem. 2003. PMID: 12215456 Free article.
A role for the alpha-chain connecting peptide motif in mediating TCR-CD8 cooperation.
Naeher D, Luescher IF, Palmer E. Naeher D, et al. J Immunol. 2002 Sep 15;169(6):2964-70. doi: 10.4049/jimmunol.169.6.2964. J Immunol. 2002. PMID: 12218110 Free article.
Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance.
Stepanek O, Prabhakar AS, Osswald C, King CG, Bulek A, Naeher D, Beaufils-Hugot M, Abanto ML, Galati V, Hausmann B, Lang R, Cole DK, Huseby ES, Sewell AK, Chakraborty AK, Palmer E. Stepanek O, et al. Among authors: naeher d. Cell. 2014 Oct 9;159(2):333-45. doi: 10.1016/j.cell.2014.08.042. Epub 2014 Oct 2. Cell. 2014. PMID: 25284152 Free PMC article.
Optimal T-cell receptor affinity for inducing autoimmunity.
Koehli S, Naeher D, Galati-Fournier V, Zehn D, Palmer E. Koehli S, et al. Among authors: naeher d. Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17248-53. doi: 10.1073/pnas.1402724111. Epub 2014 Nov 19. Proc Natl Acad Sci U S A. 2014. PMID: 25411315 Free PMC article.
The topogenic contribution of uncharged amino acids on signal sequence orientation in the endoplasmic reticulum.
Rösch K, Naeher D, Laird V, Goder V, Spiess M. Rösch K, et al. Among authors: naeher d. J Biol Chem. 2000 May 19;275(20):14916-22. doi: 10.1074/jbc.M000456200. J Biol Chem. 2000. PMID: 10747915
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