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9-(2-phosphonylmethoxyethyl)-N6-cyclopropyl-2,6-diaminopurine: a novel prodrug of 9-(2-phosphonylmethoxyethyl)guanine with improved antitumor efficacy and selectivity in choriocarcinoma-bearing rats.
Naesens L, Hatse S, Segers C, Verbeken E, De Clercq E, Waer M, Balzarini J. Naesens L, et al. Oncol Res. 1999;11(4):195-203. Oncol Res. 1999. PMID: 10566618
First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity.
Eng WS, Hocková D, Špaček P, Janeba Z, West NP, Woods K, Naesens LM, Keough DT, Guddat LW. Eng WS, et al. Among authors: naesens lm. J Med Chem. 2015 Jun 11;58(11):4822-38. doi: 10.1021/acs.jmedchem.5b00611. Epub 2015 May 13. J Med Chem. 2015. PMID: 25915781
Cidofovir is active against human papillomavirus positive and negative head and neck and cervical tumor cells by causing DNA damage as one of its working mechanisms.
Mertens B, Nogueira T, Stranska R, Naesens L, Andrei G, Snoeck R. Mertens B, et al. Among authors: naesens l. Oncotarget. 2016 Jul 26;7(30):47302-47318. doi: 10.18632/oncotarget.10100. Oncotarget. 2016. PMID: 27331622 Free PMC article.
Cidofovir selectivity is based on the different response of normal and cancer cells to DNA damage.
De Schutter T, Andrei G, Topalis D, Naesens L, Snoeck R. De Schutter T, et al. Among authors: naesens l. BMC Med Genomics. 2013 May 23;6:18. doi: 10.1186/1755-8794-6-18. BMC Med Genomics. 2013. PMID: 23702334 Free PMC article.
Cidofovir treatment improves the pathology caused by the growth of human papillomavirus-positive cervical carcinoma xenografts in athymic nude mice.
De Schutter T, Andrei G, Topalis D, Duraffour S, Mitera T, Naesens L, van den Oord J, Matthys P, Snoeck R. De Schutter T, et al. Among authors: naesens l. Cancer Lett. 2013 Feb 28;329(2):137-45. doi: 10.1016/j.canlet.2012.10.036. Epub 2012 Nov 8. Cancer Lett. 2013. PMID: 23142293
Evaluation of novel acyclic nucleoside phosphonates against human and animal gammaherpesviruses revealed an altered metabolism of cyclic prodrugs upon Epstein-Barr virus reactivation in P3HR-1 cells.
Coen N, Duraffour S, Naesens L, Krecmerová M, Van den Oord J, Snoeck R, Andrei G. Coen N, et al. Among authors: naesens l. J Virol. 2013 Nov;87(22):12422-32. doi: 10.1128/JVI.02231-13. Epub 2013 Sep 11. J Virol. 2013. PMID: 24027315 Free PMC article.
Anti-influenza virus activity and structure-activity relationship of aglycoristocetin derivatives with cyclobutenedione carrying hydrophobic chains.
Naesens L, Vanderlinden E, Roth E, Jeko J, Andrei G, Snoeck R, Pannecouque C, Illyés E, Batta G, Herczegh P, Sztaricskai F. Naesens L, et al. Antiviral Res. 2009 Apr;82(1):89-94. doi: 10.1016/j.antiviral.2009.01.003. Epub 2009 Feb 5. Antiviral Res. 2009. PMID: 19200809 Free PMC article.
Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine.
Naesens L, Andrei G, Votruba I, Krecmerová M, Holý A, Neyts J, De Clercq E, Snoeck R. Naesens L, et al. Biochem Pharmacol. 2008 Oct 15;76(8):997-1005. doi: 10.1016/j.bcp.2008.08.009. Epub 2008 Aug 19. Biochem Pharmacol. 2008. PMID: 18773877
Antiviral properties of new arylsulfone derivatives with activity against human betaherpesviruses.
Naesens L, Stephens CE, Andrei G, Loregian A, De Bolle L, Snoeck R, Sowell JW, De Clercq E. Naesens L, et al. Antiviral Res. 2006 Oct;72(1):60-7. doi: 10.1016/j.antiviral.2006.03.013. Epub 2006 Apr 18. Antiviral Res. 2006. PMID: 16650489
2-Chloro-3-pyridin-3-yl-5,6,7,8-tetrahydroindolizine-1-carboxamide (CMV423), a new lead compound for the treatment of human cytomegalovirus infections.
Snoeck R, Andrei G, Bodaghi B, Lagneaux L, Daelemans D, de Clercq E, Neyts J, Schols D, Naesens L, Michelson S, Bron D, Otto MJ, Bousseau A, Nemecek C, Roy C. Snoeck R, et al. Among authors: naesens l. Antiviral Res. 2002 Sep;55(3):413-24. doi: 10.1016/s0166-3542(02)00074-8. Antiviral Res. 2002. PMID: 12206879
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