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Intranasal administration of a meningococcal outer membrane vesicle vaccine induces persistent local mucosal antibodies and serum antibodies with strong bactericidal activity in humans.
Haneberg B, Dalseg R, Wedege E, Høiby EA, Haugen IL, Oftung F, Andersen SR, Naess LM, Aase A, Michaelsen TE, Holst J. Haneberg B, et al. Among authors: naess lm. Infect Immun. 1998 Apr;66(4):1334-41. doi: 10.1128/IAI.66.4.1334-1341.1998. Infect Immun. 1998. PMID: 9529050 Free PMC article.
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