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Activation of the trigeminal α2-adrenoceptor produces sex-specific, estrogen dependent thermal antinociception and antihyperalgesia using an operant pain assay in the rat.
Nag S, Mokha SS. Nag S, et al. Behav Brain Res. 2016 Nov 1;314:152-8. doi: 10.1016/j.bbr.2016.08.012. Epub 2016 Aug 6. Behav Brain Res. 2016. PMID: 27506651 Free PMC article.
Estrogen facilitates and the kappa and mu opioid receptors mediate antinociception produced by intrathecal (-)-pentazocine in female rats.
Robinson DL Jr, Nag S, Mokha SS. Robinson DL Jr, et al. Behav Brain Res. 2016 Oct 1;312:163-8. doi: 10.1016/j.bbr.2016.06.019. Epub 2016 Jun 14. Behav Brain Res. 2016. PMID: 27312267 Free PMC article.
Activation of opioid receptor like-1 receptor in the spinal cord produces sex-specific antinociception in the rat: estrogen attenuates antinociception in the female, whereas testosterone is required for the expression of antinociception in the male.
Claiborne J, Nag S, Mokha SS. Claiborne J, et al. J Neurosci. 2006 Dec 13;26(50):13048-53. doi: 10.1523/JNEUROSCI.4783-06.2006. J Neurosci. 2006. PMID: 17167094 Free PMC article.
Knockout of spinophilin, an endogenous antagonist of arrestin-dependent alpha2-adrenoceptor functions, enhances receptor-mediated antinociception yet does not eliminate sex-related differences.
Nag S, Wang Q, Limbird LE, Mokha SS. Nag S, et al. Behav Brain Res. 2009 Feb 11;197(2):457-61. doi: 10.1016/j.bbr.2008.09.036. Epub 2008 Oct 8. Behav Brain Res. 2009. PMID: 18957308 Free PMC article.
Activation of a Gq-coupled membrane estrogen receptor rapidly attenuates α2-adrenoceptor-induced antinociception via an ERK I/II-dependent, non-genomic mechanism in the female rat.
Nag S, Mokha SS. Nag S, et al. Neuroscience. 2014 May 16;267:122-34. doi: 10.1016/j.neuroscience.2014.02.040. Epub 2014 Mar 6. Neuroscience. 2014. PMID: 24613724 Free PMC article.
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