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In vitro antibacterial activity and mechanism of action of J-111,225, a novel 1beta-methylcarbapenem, against transferable IMP-1 metallo-beta-lactamase producers.
Nagano R, Adachi Y, Hashizume T, Morishima H. Nagano R, et al. J Antimicrob Chemother. 2000 Mar;45(3):271-6. doi: 10.1093/jac/45.3.271. J Antimicrob Chemother. 2000. PMID: 10702544
A novel 1beta-methylcarbapenem, J-111,225: effects of the C-3 and C-5 stereochemistry of the pyrrolidinylthio side chain on antibacterial activities.
Imamura H, Shimizu A, Sato H, Sugimoto Y, Sakuraba S, Nagano R, Yamada K, Hashizume T, Morishima H. Imamura H, et al. J Antibiot (Tokyo). 2000 Mar;53(3):314-6. doi: 10.7164/antibiotics.53.314. J Antibiot (Tokyo). 2000. PMID: 10819306 No abstract available.
Discovery of novel trans-3,5-disubstituted pyrrolidinylthio-1beta-methylcarbapenems.
Imamura H, Ohtake N, Shimizu A, Sato H, Sugimoto Y, Sakuraba S, Nagano R, Nakano M, Abe S, Suzuki-Sato C, Nishimura I, Kojima H, Tsuchiya Y, Yamada K, Hashizume T, Morishima H. Imamura H, et al. Bioorg Med Chem. 2000 Aug;8(8):1969-82. doi: 10.1016/s0968-0896(00)00125-5. Bioorg Med Chem. 2000. PMID: 11003142
Dicationic dithiocarbamate carbapenems with anti-MRSA activity.
Imamura H, Ohtake N, Jona H, Shimizu A, Moriya M, Sato H, Sugimoto Y, Ikeura C, Kiyonaga H, Nakano M, Nagano R, Abe S, Yamada K, Hashizume T, Morishima H. Imamura H, et al. Bioorg Med Chem. 2001 Jun;9(6):1571-8. doi: 10.1016/s0968-0896(01)00044-x. Bioorg Med Chem. 2001. PMID: 11408176
Therapeutic efficacy of J-111,225, a novel trans-3,5-disubstituted pyrrolidinylthio-1beta-methylcarbapenem, against experimental murine systemic infections.
Shibata K, Nagano R, Hashizume T, Morishima H. Shibata K, et al. J Antimicrob Chemother. 2000 Mar;45(3):379-82. doi: 10.1093/jac/45.3.379. J Antimicrob Chemother. 2000. PMID: 10702562
In vitro activities of novel trans-3,5-disubstituted pyrrolidinylthio-1beta-methylcarbapenems with potent activities against methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa.
Nagano R, Shibata K, Adachi Y, Imamura H, Hashizume T, Morishima H. Nagano R, et al. Antimicrob Agents Chemother. 2000 Mar;44(3):489-95. doi: 10.1128/aac.44.3.489-495.2000. Antimicrob Agents Chemother. 2000. PMID: 10681308 Free PMC article.
Structure-activity relationships of trans-3,5-disubstituted pyrrolidinylthio-1beta-methylcarbapenems. Part 2: J-111,225, J-114,870, J-114,871 and related compounds.
Imamura H, Ohtake N, Shimizu A, Sato H, Sugimoto Y, Sakuraba S, Kiyonaga H, Suzuki-Sato C, Nakano M, Nagano R, Yamada K, Hashizume T, Morishima H. Imamura H, et al. Bioorg Med Chem Lett. 2000 Jan 17;10(2):115-8. doi: 10.1016/s0960-894x(99)00656-3. Bioorg Med Chem Lett. 2000. PMID: 10673092
Structure-activity relationships of trans-3,5-disubstituted pyrrolidinylthio-1beta-methylcarbapenems. Part 1: J-111,347 and related compounds.
Imamura H, Ohtake N, Shimizu A, Jona H, Sato H, Nagano R, Ushijima R, Yamada K, Hashizume T, Morishima H. Imamura H, et al. Bioorg Med Chem Lett. 2000 Jan 17;10(2):109-13. doi: 10.1016/s0960-894x(99)00657-5. Bioorg Med Chem Lett. 2000. PMID: 10673091
Carbapenem derivatives as potential inhibitors of various beta-lactamases, including class B metallo-beta-lactamases.
Nagano R, Adachi Y, Imamura H, Yamada K, Hashizume T, Morishima H. Nagano R, et al. Antimicrob Agents Chemother. 1999 Oct;43(10):2497-503. doi: 10.1128/AAC.43.10.2497. Antimicrob Agents Chemother. 1999. PMID: 10508031 Free PMC article.
In vitro and in vivo evaluation of BO-2727 against imipenem- and/or meropenem-resistant Pseudomonas aeruginosa.
Shibata K, Adachi Y, Kato E, Nagano R, Fuse A, Hashizume T, Ohtake N, Okamoto O, Nakagawa S. Shibata K, et al. J Antibiot (Tokyo). 1997 Feb;50(2):135-8. doi: 10.7164/antibiotics.50.135. J Antibiot (Tokyo). 1997. PMID: 9099222
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