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Page 1
In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia.
Barrow JC, Nantermet PG, Selnick HG, Glass KL, Rittle KE, Gilbert KF, Steele TG, Homnick CF, Freidinger RM, Ransom RW, Kling P, Reiss D, Broten TP, Schorn TW, Chang RS, O'Malley SS, Olah TV, Ellis JD, Barrish A, Kassahun K, Leppert P, Nagarathnam D, Forray C. Barrow JC, et al. Among authors: nagarathnam d. J Med Chem. 2000 Jul 13;43(14):2703-18. doi: 10.1021/jm990612y. J Med Chem. 2000. PMID: 10893308
Phenylacetamides as selective alpha-1A adrenergic receptor antagonists.
Patane MA, DiPardo RM, Newton RC, Price RP, Broten TP, Chang RS, Ransom RW, Di Salvo J, Nagarathnam D, Forray C, Gluchowski C, Bock MG. Patane MA, et al. Among authors: nagarathnam d. Bioorg Med Chem Lett. 2000 Aug 7;10(15):1621-4. doi: 10.1016/s0960-894x(00)00307-3. Bioorg Med Chem Lett. 2000. PMID: 10937709
De novo design of a novel oxazolidinone analogue as a potent and selective alpha1A adrenergic receptor antagonist with high oral bioavailability.
Lagu B, Tian D, Jeon Y, Li C, Wetzel JM, Nagarathnam D, Shen Q, Forray C, Chang RS, Broten TP, Ransom RW, Chan TB, O'Malley SS, Schorn TW, Rodrigues AD, Kassahun K, Pettibone DJ, Freidinger RO, Gluchowski C. Lagu B, et al. Among authors: nagarathnam d. J Med Chem. 2000 Jul 27;43(15):2775-8. doi: 10.1021/jm000085e. J Med Chem. 2000. PMID: 10956183 No abstract available.
Design and synthesis of novel dihydropyridine alpha-1a antagonists.
Marzabadi MR, Hong X, Nagarathnam D, Miao SW, Chiu G, Wong WC, Wetzel JM, Fang J, Forray C, Chen TB, O'Malley SS, Chang RS, Gluchowski C. Marzabadi MR, et al. Among authors: nagarathnam d. Bioorg Med Chem Lett. 1999 Oct 4;9(19):2843-8. doi: 10.1016/s0960-894x(99)00484-9. Bioorg Med Chem Lett. 1999. PMID: 10522703
Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 1. Structure-activity relationship in dihydropyrimidinones.
Nagarathnam D, Miao SW, Lagu B, Chiu G, Fang J, Murali Dhar TG, Zhang J, Tyagarajan S, Marzabadi MR, Zhang F, Wong WC, Sun W, Tian D, Wetzel JM, Forray C, Chang RS, Broten TP, Ransom RW, Schorn TW, Chen TB, O'Malley S, Kling P, Schneck K, Bendesky R, Harrell CM, et al. Nagarathnam D, et al. J Med Chem. 1999 Nov 18;42(23):4764-77. doi: 10.1021/jm990200p. J Med Chem. 1999. PMID: 10579840
Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety.
Murali Dhar TG, Nagarathnam D, Marzabadi MR, Lagu B, Wong WC, Chiu G, Tyagarajan S, Miao SW, Zhang F, Sun W, Tian D, Shen Q, Zhang J, Wetzel JM, Forray C, Chang RS, Broten TP, Schorn TW, Chen TB, O'Malley S, Ransom R, Schneck K, Bendesky R, Harrell CM, Vyas KP, et al. Murali Dhar TG, et al. Among authors: nagarathnam d. J Med Chem. 1999 Nov 18;42(23):4778-93. doi: 10.1021/jm990201h. J Med Chem. 1999. PMID: 10579841
Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 3. Approaches to eliminate opioid agonist metabolites by using substituted phenylpiperazine side chains.
Lagu B, Tian D, Nagarathnam D, Marzabadi MR, Wong WC, Miao SW, Zhang F, Sun W, Chiu G, Fang J, Forray C, Chang RS, Ransom RW, Chen TB, O'Malley S, Zhang K, Vyas KP, Gluchowski C. Lagu B, et al. Among authors: nagarathnam d. J Med Chem. 1999 Nov 18;42(23):4794-803. doi: 10.1021/jm990202+. J Med Chem. 1999. PMID: 10579842
27 results