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1,393 results
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Levels of gamma-H2AX Foci after low-dose-rate irradiation reveal a DNA DSB rejoining defect in cells from human ATM heterozygotes in two at families and in another apparently normal individual.
Kato TA, Nagasawa H, Weil MM, Little JB, Bedford JS. Kato TA, et al. Among authors: nagasawa h. Radiat Res. 2006 Sep;166(3):443-53. doi: 10.1667/RR3604.1. Radiat Res. 2006. PMID: 16953663
Involvement of the nonhomologous end joining DNA repair pathway in the bystander effect for chromosomal aberrations.
Little JB, Nagasawa H, Li GC, Chen DJ. Little JB, et al. Among authors: nagasawa h. Radiat Res. 2003 Feb;159(2):262-7. doi: 10.1667/0033-7587(2003)159[0262:iotnej]2.0.co;2. Radiat Res. 2003. PMID: 12537532
A defect in DNA double strand break processing in cells from unaffected parents of retinoblastoma patients and other apparently normal humans.
Kato TA, Wilson PF, Nagasawa H, Fitzek MM, Weil MM, Little JB, Bedford JS. Kato TA, et al. Among authors: nagasawa h. DNA Repair (Amst). 2007 Jun 1;6(6):818-29. doi: 10.1016/j.dnarep.2007.01.008. Epub 2007 Mar 6. DNA Repair (Amst). 2007. PMID: 17339135
Low doses of alpha particles do not induce sister chromatid exchanges in bystander Chinese hamster cells defective in homologous recombination.
Nagasawa H, Wilson PF, Chen DJ, Thompson LH, Bedford JS, Little JB. Nagasawa H, et al. DNA Repair (Amst). 2008 Mar 1;7(3):515-22. doi: 10.1016/j.dnarep.2007.11.014. Epub 2008 Jan 7. DNA Repair (Amst). 2008. PMID: 18182331
Furthermore, when irradiated with very low doses of alpha particles, SCEs were not induced in irs3 cells, as compared to a prominent bystander effect observed in V79 cells [H. Nagasawa, Y. Peng, P.F. Wilson, Y.C. Lio, D.J. Chen, J.S. Bedford, J.B. ...
Furthermore, when irradiated with very low doses of alpha particles, SCEs were not induced in irs3 cells, as compared to a prominent bystand …
Silencing expression of the catalytic subunit of DNA-dependent protein kinase by small interfering RNA sensitizes human cells for radiation-induced chromosome damage, cell killing, and mutation.
Peng Y, Zhang Q, Nagasawa H, Okayasu R, Liber HL, Bedford JS. Peng Y, et al. Among authors: nagasawa h. Cancer Res. 2002 Nov 15;62(22):6400-4. Cancer Res. 2002. PMID: 12438223
Bystander effect for chromosomal aberrations induced in wild-type and repair deficient CHO cells by low fluences of alpha particles.
Nagasawa H, Little JB. Nagasawa H, et al. Mutat Res. 2002 Oct 31;508(1-2):121-9. doi: 10.1016/s0027-5107(02)00193-8. Mutat Res. 2002. PMID: 12379467
Differing responses of Nijmegen breakage syndrome and ataxia telangiectasia cells to ionizing radiation.
Little JB, Nagasawa H, Dahlberg WK, Zdzienicka MZ, Burma S, Chen DJ. Little JB, et al. Among authors: nagasawa h. Radiat Res. 2002 Sep;158(3):319-26. doi: 10.1667/0033-7587(2002)158[0319:dronbs]2.0.co;2. Radiat Res. 2002. PMID: 12175309
Coordination of the Ser2056 and Thr2609 Clusters of DNA-PKcs in Regulating Gamma Rays and Extremely Low Fluencies of Alpha-Particle Irradiation to G0/G1 Phase Cells.
Nagasawa H, Lin YF, Kato TA, Brogan JR, Shih HY, Kurimasa A, Bedford JS, Chen BP, Little JB. Nagasawa H, et al. Radiat Res. 2017 Feb;187(2):259-267. doi: 10.1667/RR14679.1. Epub 2017 Jan 24. Radiat Res. 2017. PMID: 28118114 Free PMC article.
Differential radiosensitivity phenotypes of DNA-PKcs mutations affecting NHEJ and HRR systems following irradiation with gamma-rays or very low fluences of alpha particles.
Lin YF, Nagasawa H, Little JB, Kato TA, Shih HY, Xie XJ, Wilson PF Jr, Brogan JR, Kurimasa A, Chen DJ, Bedford JS, Chen BP. Lin YF, et al. Among authors: nagasawa h. PLoS One. 2014 Apr 8;9(4):e93579. doi: 10.1371/journal.pone.0093579. eCollection 2014. PLoS One. 2014. PMID: 24714417 Free PMC article.
Genetic susceptibility: radiation effects relevant to space travel.
Peng Y, Nagasawa H, Warner C, Bedford JS. Peng Y, et al. Among authors: nagasawa h. Health Phys. 2012 Nov;103(5):607-20. doi: 10.1097/HP.0b013e31826945b9. Health Phys. 2012. PMID: 23032891
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