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Silencing expression of the catalytic subunit of DNA-dependent protein kinase by small interfering RNA sensitizes human cells for radiation-induced chromosome damage, cell killing, and mutation.
Peng Y, Zhang Q, Nagasawa H, Okayasu R, Liber HL, Bedford JS. Peng Y, et al. Cancer Res. 2002 Nov 15;62(22):6400-4. Cancer Res. 2002. PMID: 12438223
Differing responses of Nijmegen breakage syndrome and ataxia telangiectasia cells to ionizing radiation.
Little JB, Nagasawa H, Dahlberg WK, Zdzienicka MZ, Burma S, Chen DJ. Little JB, et al. Radiat Res. 2002 Sep;158(3):319-26. doi: 10.1667/0033-7587(2002)158[0319:dronbs]2.0.co;2. Radiat Res. 2002. PMID: 12175309
TP53 and CDKN1A (also known as p21(Waf1)) expression was attenuated in irradiated NBS cells, but maximal induction occurred 2 h postirradiation, as was observed in normal controls. ...
TP53 and CDKN1A (also known as p21(Waf1)) expression was attenuated in irradiated NBS cells, but maximal induction occurred 2 h posti …
Coordination of the Ser2056 and Thr2609 Clusters of DNA-PKcs in Regulating Gamma Rays and Extremely Low Fluencies of Alpha-Particle Irradiation to G0/G1 Phase Cells.
Nagasawa H, Lin YF, Kato TA, Brogan JR, Shih HY, Kurimasa A, Bedford JS, Chen BP, Little JB. Nagasawa H, et al. Radiat Res. 2017 Feb;187(2):259-267. doi: 10.1667/RR14679.1. Epub 2017 Jan 24. Radiat Res. 2017. PMID: 28118114 Free PMC article.
Differential role of DNA-PKcs phosphorylations and kinase activity in radiosensitivity and chromosomal instability.
Nagasawa H, Little JB, Lin YF, So S, Kurimasa A, Peng Y, Brogan JR, Chen DJ, Bedford JS, Chen BP. Nagasawa H, et al. Radiat Res. 2011 Jan;175(1):83-9. doi: 10.1667/RR2092.1. Epub 2010 Nov 17. Radiat Res. 2011. PMID: 21175350 Free PMC article.
G2-phase chromosomal radiosensitivity of primary fibroblasts from hereditary retinoblastoma family members and some apparently normal controls.
Wilson PF, Nagasawa H, Fitzek MM, Little JB, Bedford JS. Wilson PF, et al. Radiat Res. 2010 Jan;173(1):62-70. doi: 10.1667/RR1943.1. Radiat Res. 2010. PMID: 20041760 Free PMC article.
Comparison of several radiation effects in human MCF10A mammary epithelial cells cultured as 2D monolayers or 3D acinar stuctures in matrigel.
Lin YF, Nagasawa H, Peng Y, Chuang EY, Bedford JS. Lin YF, et al. Radiat Res. 2009 Jun;171(6):708-15. doi: 10.1667/RR1554.1. Radiat Res. 2009. PMID: 19580477
The responses examined were reproductive cell death, induction of chromosomal aberrations, and the levels of gamma-H2AX foci in cells after single acute gamma-ray doses and immediately after 20 h of irradiation at a dose rate of 0.0017 Gy/min. ...
The responses examined were reproductive cell death, induction of chromosomal aberrations, and the levels of gamma-H2AX foci in cells after …
Radiation sensitivity of primary fibroblasts from hereditary retinoblastoma family members and some apparently normal controls: colony formation ability during continuous low-dose-rate gamma irradiation.
Wilson PF, Nagasawa H, Warner CL, Fitzek MM, Little JB, Bedford JS. Wilson PF, et al. Radiat Res. 2008 May;169(5):483-94. doi: 10.1667/RR1333.1. Radiat Res. 2008. PMID: 18439048
In the present study, we measured the colony formation ability of these cells after exposure to continuous low-dose-rate (0.5-8.4 cGy/h) (137)Cs gamma radiation for a 2-week growth period. ...The average dose rates required to reduce relative survival to 10% and 1% were ap …
In the present study, we measured the colony formation ability of these cells after exposure to continuous low-dose-rate (0.5-8.4 cGy/h
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