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Essential role of Mash-2 in extraembryonic development.
Guillemot F, Nagy A, Auerbach A, Rossant J, Joyner AL. Guillemot F, et al. Among authors: nagy a. Nature. 1994 Sep 22;371(6495):333-6. doi: 10.1038/371333a0. Nature. 1994. PMID: 8090202
Lineage-specific transcription factors may be important in lineage specification, and the product of the Mash-2 gene fulfils the criteria for such a factor. ...Mash-2 is the first transcription factor shown to play a critical part in the development of the mammalian …
Lineage-specific transcription factors may be important in lineage specification, and the product of the Mash-2 gene fulfils the criteria fo …
Long-term reconstitution of the mouse hematopoietic system by embryonic stem cell-derived fetal liver.
Forrester LM, Bernstein A, Rossant J, Nagy A. Forrester LM, et al. Among authors: nagy a. Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7514-7. doi: 10.1073/pnas.88.17.7514. Proc Natl Acad Sci U S A. 1991. PMID: 1881890 Free PMC article.
Murine embryonic stem (ES) cells are permanent blastocyst-derived cell lines capable of contributing to a wide variety of tissues, including the germ line, after injection into host blastocysts. ...Completely ES cell-derived embryos die perinatally, but the liver of these …
Murine embryonic stem (ES) cells are permanent blastocyst-derived cell lines capable of contributing to a wide variety of tissues, in …
Embryonic stem cells alone are able to support fetal development in the mouse.
Nagy A, Gócza E, Diaz EM, Prideaux VR, Iványi E, Markkula M, Rossant J. Nagy A, et al. Development. 1990 Nov;110(3):815-21. Development. 1990. PMID: 2088722
The present results prove that ES cells are able to support complete fetal development, resulting in ES-derived newborns, and suggest a useful route for studying the development of genetically manipulated ES cells in all fetal lineages....
The present results prove that ES cells are able to support complete fetal development, resulting in ES-derived newborns, and suggest a
Genome engineering: the new mouse genetics.
Rossant J, Nagy A. Rossant J, et al. Among authors: nagy a. Nat Med. 1995 Jun;1(6):592-4. doi: 10.1038/nm0695-592. Nat Med. 1995. PMID: 7585128 Review. No abstract available.
Genomic imprinting of Mash2, a mouse gene required for trophoblast development.
Guillemot F, Caspary T, Tilghman SM, Copeland NG, Gilbert DJ, Jenkins NA, Anderson DJ, Joyner AL, Rossant J, Nagy A. Guillemot F, et al. Among authors: nagy a. Nat Genet. 1995 Mar;9(3):235-42. doi: 10.1038/ng0395-235. Nat Genet. 1995. PMID: 7773285
The mouse gene Mash2 encodes a transcription factor required for development of trophoblast progenitors. Mash2-homozygous mutant embryos die at 10 days postcoitum from placental failure. ...First, Mash2+/- embryos inheriting a wild-type allele from their father die …
The mouse gene Mash2 encodes a transcription factor required for development of trophoblast progenitors. Mash2-homozygous mutant embr …
Genome manipulation in embryonic stem cells.
Rossant J, Bernelot-Moens C, Nagy A. Rossant J, et al. Among authors: nagy a. Philos Trans R Soc Lond B Biol Sci. 1993 Feb 27;339(1288):207-15. doi: 10.1098/rstb.1993.0018. Philos Trans R Soc Lond B Biol Sci. 1993. PMID: 8097050 Review.
Embryonic stem (ES) cells derived from pluripotent cells of the early mouse embryo provide a powerful tool for genome manipulation in mammals. Dominantly acting effects can be achieved by introducing constructs to misexpress or ectopically express a gene product, ex …
Embryonic stem (ES) cells derived from pluripotent cells of the early mouse embryo provide a powerful tool for genome manipulation in …
Non-injection methods for the production of embryonic stem cell-embryo chimaeras.
Wood SA, Allen ND, Rossant J, Auerbach A, Nagy A. Wood SA, et al. Among authors: nagy a. Nature. 1993 Sep 2;365(6441):87-9. doi: 10.1038/365087a0. Nature. 1993. PMID: 8361547
The simple aggregation of pluripotent ES cells with morulae-stage embryos can result in viable chimaeras at a similar frequency to that of blastocyst injection. ...
The simple aggregation of pluripotent ES cells with morulae-stage embryos can result in viable chimaeras at a similar frequency to th …
Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.
Nagy A, Rossant J, Nagy R, Abramow-Newerly W, Roder JC. Nagy A, et al. Among authors: nagy r. Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8424-8. doi: 10.1073/pnas.90.18.8424. Proc Natl Acad Sci U S A. 1993. PMID: 8378314 Free PMC article.
Targeted mutagenesis: analysis of phenotype without germ line transmission.
Nagy A, Rossant J. Nagy A, et al. J Clin Invest. 1996 Mar 15;97(6):1360-5. doi: 10.1172/JCI118555. J Clin Invest. 1996. PMID: 8617866 Free PMC article. Review.
An induction gene trap screen in embryonic stem cells: Identification of genes that respond to retinoic acid in vitro.
Forrester LM, Nagy A, Sam M, Watt A, Stevenson L, Bernstein A, Joyner AL, Wurst W. Forrester LM, et al. Among authors: nagy a. Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1677-82. doi: 10.1073/pnas.93.4.1677. Proc Natl Acad Sci U S A. 1996. PMID: 8643689 Free PMC article.
We have developed a novel induction gene trap approach that preselects in vitro for integrations into genes that lie downstream of receptor/ligand-mediated signaling pathways. ...
We have developed a novel induction gene trap approach that preselects in vitro for integrations into genes that lie downstream of re …
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