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Thiamine derivatives bind messenger RNAs directly to regulate bacterial gene expression.
Winkler W, Nahvi A, Breaker RR. Winkler W, et al. Among authors: nahvi a. Nature. 2002 Oct 31;419(6910):952-6. doi: 10.1038/nature01145. Epub 2002 Oct 16. Nature. 2002. PMID: 12410317
The mRNA-effector complex adopts a distinct structure that sequesters the ribosome-binding site and leads to a reduction in gene expression. This metabolite-sensing regulatory system provides an example of a 'riboswitch' whose evolutionary origin might pre-da …
The mRNA-effector complex adopts a distinct structure that sequesters the ribosome-binding site and leads to a reduction in ge …
Selective small-molecule inhibition of an RNA structural element.
Howe JA, Wang H, Fischmann TO, Balibar CJ, Xiao L, Galgoci AM, Malinverni JC, Mayhood T, Villafania A, Nahvi A, Murgolo N, Barbieri CM, Mann PA, Carr D, Xia E, Zuck P, Riley D, Painter RE, Walker SS, Sherborne B, de Jesus R, Pan W, Plotkin MA, Wu J, Rindgen D, Cummings J, Garlisi CG, Zhang R, Sheth PR, Gill CJ, Tang H, Roemer T. Howe JA, et al. Among authors: nahvi a. Nature. 2015 Oct 29;526(7575):672-7. doi: 10.1038/nature15542. Epub 2015 Sep 30. Nature. 2015. PMID: 26416753
Riboswitches are non-coding RNA structures located in messenger RNAs that bind endogenous ligands, such as a specific metabolite or ion, to regulate gene expression. ...Here we report the discovery and characterization of ribocil, a highly selective chemical modulat …
Riboswitches are non-coding RNA structures located in messenger RNAs that bind endogenous ligands, such as a specific metabolite or i …
Characteristics of the glmS ribozyme suggest only structural roles for divalent metal ions.
Roth A, Nahvi A, Lee M, Jona I, Breaker RR. Roth A, et al. Among authors: nahvi a. RNA. 2006 Apr;12(4):607-19. doi: 10.1261/rna.2266506. Epub 2006 Feb 16. RNA. 2006. PMID: 16484375 Free PMC article.
The glmS ribozyme is a riboswitch class that occurs in certain Gram-positive bacteria, where it resides within mRNAs encoding glucosamine 6-phosphate synthase. ...In this report, we present a refined secondary structure model of the glmS ribozyme and determine the i …
The glmS ribozyme is a riboswitch class that occurs in certain Gram-positive bacteria, where it resides within mRNAs encoding glucosa …
New RNA motifs suggest an expanded scope for riboswitches in bacterial genetic control.
Barrick JE, Corbino KA, Winkler WC, Nahvi A, Mandal M, Collins J, Lee M, Roth A, Sudarsan N, Jona I, Wickiser JK, Breaker RR. Barrick JE, et al. Among authors: nahvi a. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6421-6. doi: 10.1073/pnas.0308014101. Epub 2004 Apr 19. Proc Natl Acad Sci U S A. 2004. PMID: 15096624 Free PMC article.
The element located upstream of the glmS gene in Gram-positive organisms functions as a metabolite-dependent ribozyme that responds to glucosamine-6-phosphate. ...These findings indicate that riboswitches serve as a major genetic regulatory mechanism for the control …
The element located upstream of the glmS gene in Gram-positive organisms functions as a metabolite-dependent ribozyme that responds t …
Control of gene expression by a natural metabolite-responsive ribozyme.
Winkler WC, Nahvi A, Roth A, Collins JA, Breaker RR. Winkler WC, et al. Among authors: nahvi a. Nature. 2004 Mar 18;428(6980):281-6. doi: 10.1038/nature02362. Nature. 2004. PMID: 15029187
We have identified a new class of ribozymes that cleaves the messenger RNA of the glmS gene in Gram-positive bacteria. The ribozyme is activated by glucosamine-6-phosphate (GlcN6P), which is the metabolic product of the GlmS enzyme. Additional data indicate that the ribozy …
We have identified a new class of ribozymes that cleaves the messenger RNA of the glmS gene in Gram-positive bacteria. The ribozyme i …
Coenzyme B12 riboswitches are widespread genetic control elements in prokaryotes.
Nahvi A, Barrick JE, Breaker RR. Nahvi A, et al. Nucleic Acids Res. 2004 Jan 2;32(1):143-50. doi: 10.1093/nar/gkh167. Print 2004. Nucleic Acids Res. 2004. PMID: 14704351 Free PMC article.
Herein, we use a phylogenetic analysis to define a consensus sequence and secondary structure model for the ligand- binding domain of this riboswitch class. ...Biochemical and genetic characterization of this motif confirms that the RNA directly binds coenzyme B12, …
Herein, we use a phylogenetic analysis to define a consensus sequence and secondary structure model for the ligand- binding do …
An mRNA structure that controls gene expression by binding S-adenosylmethionine.
Winkler WC, Nahvi A, Sudarsan N, Barrick JE, Breaker RR. Winkler WC, et al. Among authors: nahvi a. Nat Struct Biol. 2003 Sep;10(9):701-7. doi: 10.1038/nsb967. Epub 2003 Aug 10. Nat Struct Biol. 2003. PMID: 12910260
Herein, we report that a highly conserved RNA domain found in bacteria serves as a riboswitch that responds to the coenzyme S-adenosylmethionine (SAM) with remarkably high affinity and specificity. ...
Herein, we report that a highly conserved RNA domain found in bacteria serves as a riboswitch that responds to the coenzyme S- …
Genetic control by a metabolite binding mRNA.
Nahvi A, Sudarsan N, Ebert MS, Zou X, Brown KL, Breaker RR. Nahvi A, et al. Chem Biol. 2002 Sep;9(9):1043. doi: 10.1016/s1074-5521(02)00224-7. Chem Biol. 2002. PMID: 12323379
We report that the 5'-untranslated sequence of the Escherichia coli btuB mRNA assumes a more proactive role in metabolic monitoring and genetic control. The mRNA serves as a metabolite-sensing genetic switch by selectively binding coenzyme B(12) without the need for …
We report that the 5'-untranslated sequence of the Escherichia coli btuB mRNA assumes a more proactive role in metabolic monitoring a …
Structural analysis of RNA backbone using in-line probing.
Nahvi A, Green R. Nahvi A, et al. Methods Enzymol. 2013;530:381-97. doi: 10.1016/B978-0-12-420037-1.00022-1. Methods Enzymol. 2013. PMID: 24034334
A parsimonious model for gene regulation by miRNAs.
Djuranovic S, Nahvi A, Green R. Djuranovic S, et al. Among authors: nahvi a. Science. 2011 Feb 4;331(6017):550-3. doi: 10.1126/science.1191138. Science. 2011. PMID: 21292970 Free PMC article. Review.
Here, we review gene-specific and global approaches that probe miRNA function and mechanism, looking for a unifying model. More systematic analyses of the molecular specificities of the core components coupled with analysis of the relative timing of the different events wi …
Here, we review gene-specific and global approaches that probe miRNA function and mechanism, looking for a unifying model. More syste …
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