Naito M - Search Results

1

Targeted Protein Degradation by Chimeric Small Molecules, PROTACs and SNIPERs.

Naito M, Ohoka N, Shibata N, Tsukumo Y. Naito M, et al. Front Chem. 2019 Dec 10;7:849. doi: 10.3389/fchem.2019.00849. eCollection 2019. Front Chem. 2019. PMID: 31921772 Free PMC article. Review.

2

Small molecules destabilize cIAP1 by activating auto-ubiquitylation.

Sekine K, Takubo K, Kikuchi R, Nishimoto M, Kitagawa M, Abe F, Nishikawa K, Tsuruo T, Naito M. Sekine K, et al. Among authors: naito m. J Biol Chem. 2008 Apr 4;283(14):8961-8. doi: 10.1074/jbc.M709525200. Epub 2008 Jan 29. J Biol Chem. 2008. PMID: 18230607

3

Specific degradation of CRABP-II via cIAP1-mediated ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein.

Okuhira K, Ohoka N, Sai K, Nishimaki-Mogami T, Itoh Y, Ishikawa M, Hashimoto Y, Naito M. Okuhira K, et al. Among authors: naito m. FEBS Lett. 2011 Apr 20;585(8):1147-52. doi: 10.1016/j.febslet.2011.03.019. Epub 2011 Mar 21. FEBS Lett. 2011. PMID: 21414315

4

Development of target protein-selective degradation inducer for protein knockdown.

Itoh Y, Ishikawa M, Kitaguchi R, Sato S, Naito M, Hashimoto Y. Itoh Y, et al. Among authors: naito m. Bioorg Med Chem. 2011 May 15;19(10):3229-41. doi: 10.1016/j.bmc.2011.03.057. Epub 2011 Mar 29. Bioorg Med Chem. 2011. PMID: 21515062

5

Design, synthesis and biological evaluation of nuclear receptor-degradation inducers.

Itoh Y, Kitaguchi R, Ishikawa M, Naito M, Hashimoto Y. Itoh Y, et al. Among authors: naito m. Bioorg Med Chem. 2011 Nov 15;19(22):6768-78. doi: 10.1016/j.bmc.2011.09.041. Epub 2011 Sep 29. Bioorg Med Chem. 2011. PMID: 22014751

6

Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy.

Demizu Y, Okuhira K, Motoi H, Ohno A, Shoda T, Fukuhara K, Okuda H, Naito M, Kurihara M. Demizu Y, et al. Among authors: naito m. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1793-6. doi: 10.1016/j.bmcl.2011.11.086. Epub 2011 Nov 28. Bioorg Med Chem Lett. 2012. PMID: 22277276

7

Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells.

Okuhira K, Demizu Y, Hattori T, Ohoka N, Shibata N, Nishimaki-Mogami T, Okuda H, Kurihara M, Naito M. Okuhira K, et al. Among authors: naito m. Cancer Sci. 2013 Nov;104(11):1492-8. doi: 10.1111/cas.12272. Epub 2013 Oct 11. Cancer Sci. 2013. PMID: 23992566 Free PMC article.

8

APOLLON protein promotes early mitotic CYCLIN A degradation independent of the spindle assembly checkpoint.

Kikuchi R, Ohata H, Ohoka N, Kawabata A, Naito M. Kikuchi R, et al. Among authors: naito m. J Biol Chem. 2014 Feb 7;289(6):3457-67. doi: 10.1074/jbc.M113.514430. Epub 2013 Dec 3. J Biol Chem. 2014. PMID: 24302728 Free PMC article.

9

Development of cell-penetrating R7 fragment-conjugated helical peptides as inhibitors of estrogen receptor-mediated transcription.

Nagakubo T, Demizu Y, Kanda Y, Misawa T, Shoda T, Okuhira K, Sekino Y, Naito M, Kurihara M. Nagakubo T, et al. Among authors: naito m. Bioconjug Chem. 2014 Nov 19;25(11):1921-4. doi: 10.1021/bc500480e. Epub 2014 Nov 7. Bioconjug Chem. 2014. PMID: 25375254

10

Structural development of stabilized helical peptides as inhibitors of estrogen receptor (ER)-mediated transcription.

Demizu Y, Misawa T, Nagakubo T, Kanda Y, Okuhira K, Sekino Y, Naito M, Kurihara M. Demizu Y, et al. Among authors: naito m. Bioorg Med Chem. 2015 Aug 1;23(15):4132-4138. doi: 10.1016/j.bmc.2015.06.067. Epub 2015 Jul 2. Bioorg Med Chem. 2015. PMID: 26183544

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