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Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells.
Hoshii T, Kasada A, Hatakeyama T, Ohtani M, Tadokoro Y, Naka K, Ikenoue T, Ikawa T, Kawamoto H, Fehling HJ, Araki K, Yamamura K, Matsuda S, Hirao A. Hoshii T, et al. Among authors: naka k. Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3805-10. doi: 10.1073/pnas.1320265111. Epub 2014 Feb 24. Proc Natl Acad Sci U S A. 2014. PMID: 24567410 Free PMC article.
mTORC1 is essential for leukemia propagation but not stem cell self-renewal.
Hoshii T, Tadokoro Y, Naka K, Ooshio T, Muraguchi T, Sugiyama N, Soga T, Araki K, Yamamura K, Hirao A. Hoshii T, et al. Among authors: naka k. J Clin Invest. 2012 Jun;122(6):2114-29. doi: 10.1172/JCI62279. Epub 2012 May 24. J Clin Invest. 2012. PMID: 22622041 Free PMC article.
Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin.
Tamase A, Muraguchi T, Naka K, Tanaka S, Kinoshita M, Hoshii T, Ohmura M, Shugo H, Ooshio T, Nakada M, Sawamoto K, Onodera M, Matsumoto K, Oshima M, Asano M, Saya H, Okano H, Suda T, Hamada J, Hirao A. Tamase A, et al. Among authors: naka k. Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17163-8. doi: 10.1073/pnas.0905016106. Epub 2009 Sep 17. Proc Natl Acad Sci U S A. 2009. PMID: 19805150 Free PMC article.
Association of a murine leukaemia stem cell gene signature based on nucleostemin promoter activity with prognosis of acute myeloid leukaemia in patients.
Ali MA, Naka K, Yoshida A, Fuse K, Kasada A, Hoshii T, Tadokoro Y, Ueno M, Ohta K, Kobayashi M, Takahashi C, Hirao A. Ali MA, et al. Among authors: naka k. Biochem Biophys Res Commun. 2014 Jul 18;450(1):837-43. doi: 10.1016/j.bbrc.2014.06.066. Epub 2014 Jun 21. Biochem Biophys Res Commun. 2014. PMID: 24960197
572 results