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NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3β resulting in the stabilization of MYCN in human neuroblastomas.
Suenaga Y, Islam SM, Alagu J, Kaneko Y, Kato M, Tanaka Y, Kawana H, Hossain S, Matsumoto D, Yamamoto M, Shoji W, Itami M, Shibata T, Nakamura Y, Ohira M, Haraguchi S, Takatori A, Nakagawara A. Suenaga Y, et al. Among authors: nakagawara a. PLoS Genet. 2014 Jan;10(1):e1003996. doi: 10.1371/journal.pgen.1003996. Epub 2014 Jan 2. PLoS Genet. 2014. PMID: 24391509 Free PMC article.
Oncogenic Lmo3 cooperates with Hen2 to induce hydrocephalus in mice.
Isogai E, Okumura K, Saito M, Yoshizawa Y, Itoh K, Tando S, Ohira M, Haraguchi S, Nakagawara A, Fushiki S, Nagase H, Wakabayashi Y. Isogai E, et al. Among authors: nakagawara a. Exp Anim. 2015;64(4):407-14. doi: 10.1538/expanim.15-0026. Epub 2015 Jul 6. Exp Anim. 2015. PMID: 26156403 Free PMC article.
Serum-Based Quantification of MYCN Gene Amplification in Young Patients with Neuroblastoma: Potential Utility as a Surrogate Biomarker for Neuroblastoma.
Yagyu S, Iehara T, Tanaka S, Gotoh T, Misawa-Furihata A, Sugimoto T, London WB, Hogarty MD, Teramukai S, Nakagawara A, Hiyama E, Maris JM, Hosoi H. Yagyu S, et al. Among authors: nakagawara a. PLoS One. 2016 Aug 11;11(8):e0161039. doi: 10.1371/journal.pone.0161039. eCollection 2016. PLoS One. 2016. PMID: 27513929 Free PMC article.
Positive auto-regulation of MYCN in human neuroblastoma.
Suenaga Y, Kaneko Y, Matsumoto D, Hossain MS, Ozaki T, Nakagawara A. Suenaga Y, et al. Among authors: nakagawara a. Biochem Biophys Res Commun. 2009 Dec 4;390(1):21-6. doi: 10.1016/j.bbrc.2009.09.044. Epub 2009 Sep 18. Biochem Biophys Res Commun. 2009. PMID: 19766596
409 results